Espesor epitelial corneal central y periférico, y su asociación con la edad y el sexo en pacientes adultos

Vista sencilla de ítem
dc.contributor.advisorNiño Moreno, Camilo Andrés
dc.contributor.advisorTello Hernández, Alejandro
dc.contributor.advisorVillamizar Portilla, Sylvia Juliana
dc.contributor.apolounabNiño Moreno, Camilo Andrés [camilo-andrés-niño-moreno]spa
dc.contributor.apolounabTello Hernández, Alejandro [alejandro-tello-hernández]spa
dc.contributor.apolounabVillamizar Portilla, Sylvia Juliana [sylvia-juliana-villamizar-portilla]spa
dc.contributor.authorGarcía Sánchez, Diana María
dc.contributor.cvlacNiño Moreno, Camilo Andrés [0001393674]spa
dc.contributor.cvlacTello Hernández, Alejandro [0001009125]spa
dc.contributor.cvlacVillamizar Portilla, Sylvia Juliana [0000089092]spa
dc.contributor.googlescholarTello Hernández, Alejandro [puxZHKYAAAAJ]spa
dc.contributor.googlescholarVillamizar Portilla, Sylvia Juliana [es&oi=ao]spa
dc.contributor.orcidNiño Moreno, Camilo Andrés [0000-0002-5538-1379]spa
dc.contributor.orcidTello Hernández, Alejandro [0000-0002-8478-2374]spa
dc.contributor.orcidVillamizar Portilla, Sylvia Juliana [0000-0002-7296-3522]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialFloridablanca (Santander, Colombia)spa
dc.coverage.temporal2020-2023spa
dc.date.accessioned2024-05-28T13:27:35Z
dc.date.available2024-05-28T13:27:35Z
dc.date.issued2024-05-17
dc.degree.nameEspecialista en Oftalmologíaspa
dc.description.abstractLa medida del espesor del epitelio corneal se ha convertido en una herramienta cada día más utilizada en el diagnóstico de diferentes patologías de la córnea. Para utilizar esta herramienta de manera confiable, se deben conocer las características del mapa epitelial de la población sana de nuestro medio y al comprobar si estas medidas son comparables con la población de otros países, saber si es posible utilizar los mismos criterios diagnósticos utilizados a nivel internacional. Metodología Se realizó un estudio transversal Analítico, secundario de una base de datos anonimizada del Centro Oftalmológico Virgilio Galvis. Objetivo Evaluar la asociación del espesor epitelial corneal central y periférico, medido por tomografía de coherencia óptica, con la edad y el sexo en pacientes adultos en el Centro Oftalmológico Virgilio Galvis. Resultados En una muestra de 222 ojos de pacientes adultos a quienes se les realizó un mapa epitelial corneal con topografía y tomografía de coherencia óptica (OCT) de segmento anterior con el equipo MS-39 (Costruzione Strumenti Oftalmici, Florencia, Italia). Se encontró que en los hombres el espesor promedio central fue más grueso que las mujeres con significancia estadística en todos los sectores excepto el nasal. Las correlaciones de los espesores epiteliales centrales y periféricos con la variable edad, fueron débiles. Conclusión: Los hombres presentaron un espesor epitelial más grueso que las mujeres en todas las zonas, aunque con diferente significancia estadística según el sector. Los cambios de espesor en los sectores superior e inferior parecen estar relacionados con la edad, especialmente al comparar los pacientes de mayor edad con los más jóvenes.spa
dc.description.abstractenglishThe measurement of corneal epithelial thickness has become an increasingly used tool in the diagnosis of different corneal pathologies. To use this tool reliably, one must be familiar with the characteristics of the epithelial map of the healthy local population, and corroborate if these measurements are comparable with populations from other countries, to determine if the same diagnostic criteria used internationally can be applied. Methodology: A cross-sectional analytical study was conducted using secondary data from an anonymized database of the Virgilio Galvis Ophthalmological Center (Centro Oftalmológico Virgilio Galvis). Objective: To evaluate the association of central and peripheral corneal epithelial thickness, measured by optical coherence tomography, with age and sex in adult patients at the Virgilio Galvis Ophthalmological Center (Centro Oftalmológico Virgilio Galvis). Results: In a sample of 222 eyes of adult patients who underwent corneal epithelial mapping with topography and anterior segment optical coherence tomography (OCT) using the MS-39 device (Costruzione Strumenti Oftalmici, Florence, Italy), it was found that the average central thickness was thicker in men than in women with statistical significance in all sectors except the nasal sector. The correlations of central and peripheral epithelial thicknesses with age were weak. Conclusion: Men present a thicker corneal epithelium than women in all areas, although with different statistical significance depending on the sector. Changes in thickness in the superior and inferior sectors appear to be related to age, especially when comparing older patients with younger ones.spa
dc.description.degreelevelEspecializaciónspa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontentsResumen del Proyecto 1. Justificación 2. Marco Teórico 3. Estado del Arte 4. Objetivos 4.1. Objetivo General 4.2. Objetivos Específicos 5. Metodología 5.1. Tipo de estudio 5.2. Población 5.3. Criterios de inclusión 5.4. Criterios de exclusión 5.5. Cálculo de tamaño de muestra 5.6. Muestreo 5.7. Recolección de la información 5.8. Variables 5.9. Plan de análisis de datos 5.10. Consideraciones éticas. 6. Resultados Esperados 6.1. Relacionados con la generación de nuevo conocimiento 6.2. Conducentes al fortalecimiento de la capacidad científica institucional 6.3. Dirigidos a la apropiación social del conocimiento 7. Impactos Esperados 8. Resultados 9. Discusión 10. Conclusiones 11. Referencias Bibliográficas Anexos Disposiciones Vigentes Cronograma de Actividades Presupuestospa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/24868
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programEspecialización en Oftalmologíaspa
dc.publisher.programidEOFT-1042
dc.relation.referencesReinstein DZ, Archer TJ, Vida RS. Applications of epithelial thickness mapping in corneal refractive surgery. Saudi J Ophthalmol. 2022 Jul 11;36(1):25–35.spa
dc.relation.referencesLoureiro T de O, Rodrigues-Barros S, Lopes D, Carreira AR, Gouveia-Moraes F, Vide-Escada A, et al. Corneal Epithelial Thickness Profile in Healthy Portuguese Children by High-Definition Optical Coherence Tomography. Clin Ophthalmol. 2021 Feb 24;15:735–43.spa
dc.relation.referencesZhou W, Reinstein DZ, Chen X, Chen S, Xu Y, Utheim TP, et al. Transepithelial Topography-Guided Ablation Assisted by Epithelial Thickness Mapping for Treatment of Regression After Myopic Refractive Surgery. J Refract Surg. 2019 Aug 1;35(8):525–33.spa
dc.relation.referencesOikonomakis K, Petrelli M, Petrovic A, Andreanos K, Droutsas K, Georgalas I, et al. Epithelial map-guided anterior stromal micropuncture for the treatment of recurrent corneal erosion syndrome. Int Ophthalmol. 2019 Apr;39(4):943–8.spa
dc.relation.referencesAbusamak M. Corneal Epithelial Mapping Characteristics in Normal Eyes Using Anterior Segment Spectral Domain Optical Coherence Tomography. Transl Vis Sci Technol. 2022 Mar 2;11(3):6.spa
dc.relation.referencesHashmani N, Hashmani S, Saad CM. Wide Corneal Epithelial Mapping Using an Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1652–8.spa
dc.relation.referencesOzalp O, Atalay E. Biometric Determinants of Epithelial Thickness Profile Across a Wide Range of Refractive Errors. Ophthalmol Ther. 2022 Jun;11(3):1089–100.spa
dc.relation.referencesMalhotra C, Gupta B, Dhiman R, Jain AK, Gupta A, Ram J. Corneal and corneal epithelial thickness distribution characteristics in healthy North Indian eyes using spectral domain optical coherence tomography. Indian J Ophthalmol. 2022 Apr;70(4):1171–8.spa
dc.relation.referencesReinstein DZ, Silverman RH, Sutton HF, Coleman DJ. Very high-frequency ultrasound corneal analysis identifies anatomic correlates of optical complications of lamellar refractive surgery: anatomic diagnosis in lamellar surgery. Ophthalmology. 1999 Mar;106(3):474–82.spa
dc.relation.referencesWu Y, Wang Y. Detailed Distribution of Corneal Epithelial Thickness and Correlated Characteristics Measured with SD-OCT in Myopic Eyes. J Ophthalmol. 2017 May 14;2017:1018321.spa
dc.relation.referencesRattan SA, Anwar DS. Comparison of corneal epithelial thickness profile in dry eye patients, keratoconus suspect, and healthy eyes. Eur J Ophthalmol. 2020 Nov;30(6):1506–11.spa
dc.relation.referencesReinstein DZ, Archer TJ, Gobbe M, Silverman RH, Coleman DJ. Epithelial thickness in the normal cornea: three-dimensional display with Artemis very high-frequency digital ultrasound. J Refract Surg. 2008 Jun;24(6):571–81.spa
dc.relation.referencesReinstein DZ, Archer TJ, Vida RS. Epithelial thickness mapping for corneal refractive surgery. Curr Opin Ophthalmol. 2022 Jul 1;33(4):258–68.spa
dc.relation.referencesSalomão MQ, Hofling-Lima AL, Gomes Esporcatte LP, Correa FF, Meneses EF, Li Y, et al. Corneal ectasia detection by epithelial pattern standard deviation from OCT. J Cataract Refract Surg. 2023 Feb 1;49(2):190–4.spa
dc.relation.referencesKhamar P, Rao K, Wadia K, Dalal R, Grover T, Versaci F, et al. Advanced epithelial mapping for refractive surgery. Indian J Ophthalmol. 2020 Dec;68(12):2819–30.spa
dc.relation.referencesLiang Q, Le Q, Cordova DW, Tseng CH, Deng SX. Corneal Epithelial Thickness Measured Using Anterior Segment Optical Coherence Tomography as a Diagnostic Parameter for Limbal Stem Cell Deficiency. Am J Ophthalmol. 2020 Aug;216:132–9.spa
dc.relation.referencesDavid C, Reinstein DZ, Archer TJ, Kallel S, Vida RS, Goemaere I, et al. Postoperative Corneal Epithelial Remodeling After Intracorneal Ring Segment Procedures for Keratoconus: An Optical Coherence Tomography Study. J Refract Surg. 2021 Jun;37(6):404–13.spa
dc.relation.referencesHalkiadakis I, Vernikou A, Tzimis V, Markopoulos I, Popeskou K, Konstadinidou V. Assessment of Corneal Epithelium Thickness in Glaucomatous Patients Undergoing Medical Treatment. J Glaucoma. 2021 Jan 1;30(1):44–9.spa
dc.relation.referencesLi Y, Meisler DM, Tang M, Lu ATH, Thakrar V, Reiser BJ, et al. Keratoconus diagnosis with optical coherence tomography pachymetry mapping. Ophthalmology. 2008 Dec;115(12):2159–66.spa
dc.relation.referencesFranco J, White CA, Kruh JN. Analysis of Compensatory Corneal Epithelial Thickness Changes in Keratoconus Using Corneal Tomography. Cornea. 2020 Mar;39(3):298–302.spa
dc.relation.referencesCui X, Hong J, Wang F, Deng SX, Yang Y, Zhu X, et al. Assessment of corneal epithelial thickness in dry eye patients. Optom Vis Sci. 2014 Dec;91(12):1446–54.spa
dc.relation.referencesSella R, Zangwill LM, Weinreb RN, Afshari NA. Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping With Spectral-Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes. Am J Ophthalmol. 2019 Jan;197:88–97.spa
dc.relation.referencesSchallhorn JM, Tang M, Li Y, Louie DJ, Chamberlain W, Huang D. Distinguishing between contact lens warpage and ectasia: Usefulness of optical coherence tomography epithelial thickness mapping. J Cataract Refract Surg. 2017 Jan;43(1):60–6.spa
dc.relation.referencesHong J, Qian T, Yang Y, Jiang C, Liu Z, Sun X, et al. Corneal epithelial thickness map in long-term soft contact lenses wearers. Optom Vis Sci. 2014 Dec;91(12):1455–61.spa
dc.relation.referencesAbdolalizadeh P, Karimi M, Latifi G, Nouri L, Hashemian MN, Hashemian H, et al. Role of Different Types of Contact Lenses in Epithelial Thickness. Eye Contact Lens. 2022 May 1;48(5):210–6.spa
dc.relation.referencesBuffault J, Zéboulon P, Liang H, Chiche A, Luzu J, Robin M, et al. Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy. PLoS One. 2020 Nov 25;15(11):e0239124.spa
dc.relation.referencesBaghdasaryan E, Tepelus TC, Marion KM, Bagherinia H, Sadda SR, Hsu HY. Evaluation of Corneal Epithelial Thickness Imaged by High Definition Optical Coherence Tomography in Healthy Eyes. Cornea. 2019 Jan;38(1):62–6.spa
dc.relation.referencesKim WK, Ryu IH, Yoo J, Kim SW. Effect of Gender, Age, and Ocular and Growth-Related Factors on Corneal Epithelial and Stromal Thickness in Children. J Clin Med Res [Internet]. 2020 Nov 27;9(12). Available from: http://dx.doi.org/10.3390/jcm9123849spa
dc.relation.referencesSamy MM, Shaaban YM, Badran TAF. Age- and sex-related differences in corneal epithelial thickness measured with spectral domain anterior segment optical coherence tomography among Egyptians. Medicine . 2017 Oct;96(42):e8314.spa
dc.relation.referencesHoshing AA, Bhosale S, Samant MP, Bamne A, Kalyankar H. A cross-sectional study to determine the normal corneal epithelial thickness in Indian population using 9-mm wide optical coherence tomography scans. Indian J Ophthalmol. 2021 Sep;69(9):2425–9.spa
dc.relation.referencesYang Y, Hong J, Deng SX, Xu J. Age-related changes in human corneal epithelial thickness measured with anterior segment optical coherence tomography. Invest Ophthalmol Vis Sci. 2014 Jul 22;55(8):5032–8.spa
dc.relation.referencesAhmed H. Assaf M.d. MMAELBMS;., Tamer A. Badran M.d. MGMMD;. Corneal epithelial mapping among healthy Egyptian eyes of LASIK age group using spectral domain anterior segment optical coherence tomography. Med J Cairo Univ. 2022 Jun 1;90(6):1141–8.spa
dc.relation.referencesHoshing A, Bhosale S, Samant M, Bamne A, Kalyankar H. A cross-sectional study to compare the normal corneal epithelial thickness in various age groups of Indian population using 9 mm wide optical coherence tomography scans. Indian J Ophthalmol. 2022 Feb;70(2):505–10.spa
dc.relation.uriapolohttps://apolo.unab.edu.co/en/persons/camilo-andr%C3%A9s-ni%C3%B1o-morenospa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsHealth sciencesspa
dc.subject.keywordsOphthalmologyspa
dc.subject.keywordsAgespa
dc.subject.keywordsGenderspa
dc.subject.keywordsCorneaspa
dc.subject.keywordsAnterior segment optical coherence tomographyspa
dc.subject.keywordsCorneal epithelial thicknessspa
dc.subject.keywordsAnterior segmentspa
dc.subject.keywordsAnterior segment of the eyespa
dc.subject.keywordsDiagnostic imagingspa
dc.subject.keywordsEmission tomographyspa
dc.subject.lembOftalmologíaspa
dc.subject.lembCiencias médicasspa
dc.subject.lembSegmento anterior del ojospa
dc.subject.lembCorneaspa
dc.subject.lembDiagnóstico por imágenesspa
dc.subject.lembTomografía de emisiónspa
dc.subject.proposalCiencias de la saludspa
dc.subject.proposalEdadspa
dc.subject.proposalSexospa
dc.subject.proposalEspesor epitelial cornealspa
dc.subject.proposalSegmento anteriorspa
dc.subject.proposalCórneaspa
dc.subject.proposalTomografía de coherencia óptica de segmento anteriorspa
dc.titleEspesor epitelial corneal central y periférico, y su asociación con la edad y el sexo en pacientes adultosspa
dc.title.translatedCentral and peripheral corneal epithelial thickness, and its association with age and sex in adult patientsspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.redcolhttp://purl.org/redcol/resource_type/TM

Archivos

Bloque original

Mostrando 1 - 2 de 2
Miniatura
Nombre:
Tesis.pdf
Tamaño:
7.86 MB
Formato:
Adobe Portable Document Format
Descripción:
Tesis
Descargar
Miniatura
Nombre:
2024_Licencia.pdf
Tamaño:
224.07 KB
Formato:
Adobe Portable Document Format
Descripción:
Licencia
Descargar

Bloque de licencias

Mostrando 1 - 1 de 1
Miniatura
Nombre:
license.txt
Tamaño:
829 B
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Especialización en Oftalmología