Utilidad clínica del conteo de células precursoras hematopoyéticas (CPH) comparado con el recuento de células CD 34+ en sangre periférica (SP) para la predicción de la realización de aféresis

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dc.contributor.advisorSossa Melo, Claudia Lucia
dc.contributor.authorPérez Martínez, Carlos Andrés
dc.contributor.authorJiménez, Sara Inés
dc.contributor.authorPeña, Angela María
dc.contributor.authorSalazar, Luis Antonio
dc.contributor.authorOchoa, Miguel
dc.contributor.authorMeléndez, Héctor
dc.contributor.cvlacSossa Melo, Claudia Lucía [0001425704]spa
dc.contributor.googlescholarSossa Melo, Claudia Lucía [es&oi=ao]spa
dc.contributor.orcidSossa Melo, Claudia Lucía [0000-0001-9876-222X]spa
dc.contributor.researchgateSossa Melo, Claudia Lucía [Claudia-Sossa]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialFloridablanca (Santander, Colombia)spa
dc.coverage.temporal2015spa
dc.date.accessioned2022-10-31T20:59:25Z
dc.date.available2022-10-31T20:59:25Z
dc.date.issued2015
dc.degree.nameEspecialista en Medicina Internaspa
dc.description.abstractEl éxito de un trasplante de precursores hematopoyéticas de SP depende de un adecuado número de células CD34+ infundidas, siendo el momento óptimo de la colecta por aféresis clave. Un conteo de células CD34+ en SP > de 10 x 106/l es utilizado como criterio para la realización de aféresis. Las CPHs en SP se correlacionan con las células CD34+ SP, una alternativa rápida (90 segundos), no operador dependiente, económica (USD 9.8) comparado con CD34+ SP que es costosa (USD 110.34) y consume mayor tiempo. Nuestro objetivo fue evaluar la utilidad clínica del conteo de CPHs SP tomando como referencia un conteo de CD 34+ SP > de 10 x 106/l + SP, una alternativa rápida (90 segundos), no operador dependiente, económica (USD 9.8) comparado con CD34 + SP que es costosa (USD 110.34) y consume mayor tiempo. Nuestro objetivo fue evaluar la utilidad clínica del conteo de CPHs SP tomando como referencia un conteo de CD 34.spa
dc.description.abstractenglishThe success of a transplant of hematopoietic precursors of SP depends on an adequate number of CD34+ cells infused, being the optimal moment of collection by apheresis key. A CD34+ cell count in SP > 10 x 106/l is used as a criterion for performing apheresis. HPCs in SP correlate with CD34+ SP cells, a fast (90 seconds), non-operator dependent, inexpensive (USD 9.8) alternative compared to CD34+ SP that is expensive (USD 110.34) and more time consuming. Our objective was to evaluate the clinical usefulness of counting SP hCcs taking as reference a count of CD 34+ SP > 10 x 106/l + SP, a fast alternative (90 seconds), non-operator dependent, cheap (USD 9.8) compared with CD34 + SP which is expensive (USD 110.34) and more time consuming. Our objective was to evaluate the clinical usefulness of the SP CPH count, taking a CD 34 count as a reference.spa
dc.description.degreelevelEspecializaciónspa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontents1. FICHA TECNICA PROPUESTA DE INVESTIGACION 9 1.1 RESUMEN DEL PROYECTO 10 1.2 PLANTEAMIENTO DEL PROBLEMA 12 1.3 JUSTIFICACION 14 1.4 ESTADO DEL ARTE 16 1.5 METODOLOGIA 17 1.5.1 TIPO DE ESTUDIO 17 1.5.2 POBLACION 17 1.5.3 CRITERIOS DE INCLUSION 17 1.5.4 CRITERIOS DE EXCLUSION 17 1.6 OBJETIVO GENERAL 18 1.6.1 OBJETIVO ESPECIFICOS 18 1.7 CONSIDERACIONES ETICAS 19 1.8 PACIENTES Y METODOS 20 1.8.1 POBLACION 20 1.8.2 REGIMENES DE MOVILIZACION 21 1 8.3EVALUACIÓN DE LA MOVILIZACIÓN DE 21 PRECURSORES HEMATOPOYÉTICOS 1.8.4 MEDICIÓN DE CPHS 22 1.8.5 ANÁLISIS ESTADISTICO 22 1.9. RESULTADOS 23 1.10 DISCUSION 28 1.11 BIBLIOGRAFÍA 29spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/18276
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programEspecialización en Medicina Internaspa
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dc.relation.referencesYu J, Leisenring W, Fritschle W , Heimfeld S, Shulman H, Bensinger Wl, et al. Enumeration of HPC in mobilized peripheral blood with the Sysmex SE9500 predicts final CD34+ cell yield in the apheresis collection. Bone Marrow Transplantation 2000; 25: 1157-1164.spa
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dc.relation.referencesPollard Y, Watts M.J, Grant D, Chavda N, Linch DC, Achin SJ. Use of the haemopoietic progenitor cell count of the Sysmex SE-9500 to refine apheresis timing of peripheral blood stem cells. British Journal of Haematology 1999; 106: 538-544.spa
dc.relation.referencesTeng HW , Hsiao LT ,Chaou SC , Gau JP , Lee TC , Shih YY, et al. A new model for predicting the timing of leukapheresis on the basis of CD34 + cell and hematopoietic progenitor cell levels. J of Clinical Apheresis 2007; 22: 195-203.spa
dc.relation.referencesBasquiera AL , Abichain P, Damonte JC , Ricchi B, Sturich AG, Palazzo ED , et al. The Number of CD34+ cells in peripheral blood as a predictor of the CD34+ yield ¡n patients going to autologous stem cell transplantation. J of Clinical Apheresis 2006; 21: 92-95.spa
dc.relation.referencesJae-Lyun L, Sung-Bae K, Gyeong-Won L, Min-Hee R, Eun-Kyeong K, Shin K, et al. Clinical usefulness of the hematopoietic progenitor cell counts in predicting the optimal timing of peripheral blood stem cell harvest. J Korean Med Sci 2003; 18:27-35.spa
dc.relation.referencesShang-Hsien Y, Tso-Fu W, His-Hsiu T, Teng-Y¡ L, Shu-Hui W, Shu-Huey C. Preharvest hematopoietic progenitor cell counts predict CD34+ cell yields in granulocyte-colony-stimulating factor-mobilized peripheral blood stem cell harvest in healthy donors. Transfusión 2010; 50: 1088-1095.spa
dc.relation.references.Padmanabhan A, Slotky R, Jhang J, Dael S, Crowder T, Colovai A, et al. Use of the haematopoietic progenitor cell parameter in optimizing timing of peripheral blood stem cell harvest. Vox Sanguinis (2009) 97, 153-159.spa
dc.relation.referencesMitani N, Yujiri T, Tanaka Y, Tanaka M, Fujii Y, Hinoda Y, et al. Hematopoietic Progenitor Cell Count, but Not Immature Platelet Fraction Valué, Predicts Successful Harvest ofAutologous Peripheral Blood Stem Cell. Journal of Clinical Apheresis (2011) 26:105-110spa
dc.relation.referencesOelschlaegel U, Bornhaeuser M, Thiede C, Ehninger G, Hoelig K. HPC enumeration with the Sysmex XE-2100 can guide further flow cytometric CD34 + measurements and timing of leukaphereses. Cytotherapy 2003; 5: 414-419.spa
dc.relation.referencesGowans ID, Hepburn MD, Clarck DM, Patterson G, Rawlinson PSM, Bowen DT. • The role of the Sysmex SE9000 immature myeloid índex and Sysmex R2000 reticulocyte parameters in optimizing the timing of peripheral blood stem cell 30 harvesting in patients with lymphoma and myeloma. Clin Lab Haem 1999; 21: 331-336spa
dc.relation.referencesKeon U Park, Sang HK, Cheolwon S, Shin K, Sun JL, Jung SP, et al. Correlation oí Hematopoietic Progenitor Cell Count determined by the SE9000™ Automated Hematology analyzer With CD34+ Cell Count by Flow Cytometry in Leukapheresis Products, American Journal of Hematology 2001; 67:42-47.spa
dc.relation.referencesCheolwon S, Shin K, Sang-Hee K, Eun-Kyung K, Jae-Lyun L, Keon-UK P, Jung Sun P, et al. Initation of peripheral blood progenitor cell harvest based on peripheral blood hematopoietic progenitor cell counts enumerated by the sysmex SE900, Transfusión 2004; 44:1762-1768spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsInternal medicinespa
dc.subject.keywordsMedicinespa
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsHealth sciencesspa
dc.subject.keywordsPrecursor transplantspa
dc.subject.keywordsPrecursor cell countspa
dc.subject.keywordsBlood cellsspa
dc.subject.keywordsHematopoiesisspa
dc.subject.keywordsStem cellsspa
dc.subject.lembMedicina internaspa
dc.subject.lembMedicinaspa
dc.subject.lembCiencias médicasspa
dc.subject.lembCélulas sanguíneasspa
dc.subject.lembHematopoyesisspa
dc.subject.lembCélulas progenitorasspa
dc.subject.proposalCiencias de la saludspa
dc.subject.proposalTrasplante de precursoresspa
dc.subject.proposalConteo de células precursorasspa
dc.titleUtilidad clínica del conteo de células precursoras hematopoyéticas (CPH) comparado con el recuento de células CD 34+ en sangre periférica (SP) para la predicción de la realización de aféresisspa
dc.title.translatedClinical utility of the hematopoietic precursor cell (HPC) count compared with the CD 34+ cell count in peripheral blood (PB) for the prediction of apheresis performancespa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TM

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