Implicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide

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dc.contributor.authorPáez Leal, María Carolinaspa
dc.contributor.authorGómez, Luis Miguelspa
dc.contributor.authorAnaya, Juan Manuelspa
dc.contributor.cvlacPáez Leal, María Carolina [0000066656]
dc.contributor.googlescholarPáez Leal, María Carolina [BAPR3-cAAAAJ]
dc.contributor.orcidPáez Leal, María Carolina [0000-0002-0310-0125]
dc.contributor.researchgatePáez Leal, María Carolina [profile/Maria_Paez-Leal]
dc.contributor.researchgatePáez Leal, María Carolina [profile/Maria_Paez-Leal]
dc.contributor.researchgroupGrupo de Estudio Genético de Enfermedades Complejasspa
dc.contributor.researchgroupGrupo de Investigaciones Clínicasspa
dc.contributor.scopusPáez Leal, María Carolina [12243485600]
dc.date.accessioned2020-10-27T14:21:34Z
dc.date.available2020-10-27T14:21:34Z
dc.date.issued2006-04-02
dc.description.abstractLos linfocitos B tienen un papel importante en la regulación del sistema inmune, pues además de producir anticuerpos, son células presentadoras de antígenos que interactúan con otras células mo-nonucleares y contribuyen directamente en las vías inflamatorias. Existe evidencia acerca de una disrupción en la regulación de estos procesos en la patogénesis de las enfermedades autoin-munes, tales como la artritis reumatoide (AR). Esta enfermedad se caracteriza por una inflamación crónica de las articulaciones afectadas en las que es característico el desarrollo de centros germinales ectópicos en la membrana sinovial. Este microambiente facilita la diferenciación y activación de las células B, las cuales, al transformarse en células plasmáticas, secretan directamente en la membrana sinovial anticuerpos de alta afinidad. En consecuencia, la formación de complejos inmunes con la posterior activación de la cascada del complemento y el estímulo de macrófagos, contribuyen en la destrucción de la articulación. Las células B también tienen un papel relevante en la activación de las células T sinoviales y en la inducción de la síntesis de citoquinas. Finalmente, la eficacia terapéutica obtenida con la depleción de linfocitos B por medio del uso de anticuerpos monoclonales contra CD20, enfatiza su importancia en la patogénesis de la AR [Páez M-C, Gómez LM, Anaya J-M. Functional implications of B lymphocytes in the development of reumatoide arthritis. MedUNAB 2006; 9:34-44]spa
dc.description.abstractenglishB cells play a key role in regulating the immune system by producing antibodies, acting as antigen-presenting cells, providing support to other mononuclear cells, and contributing directly to inflammatory pathways. Accumulating evidence indicates that there is a disruption of these regulated processes in the pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). In RA there is a chronic inflammation in the affected joints leading to the development of ectopic germinal centers. A micro-environment is established which supports B cell activation and differentiation. Plasma cells may develop which secrete autoantibodies of high affinity directly into the synovial tissue. As a result, antigen/antibody complex forma-tion, the activation of the complement cascade and the stimulation of macrophages may contribute to the destruction of joints. B cells also play a pivotal role in the activation of synovial T cells and the induction of cytokine secretion. Finally, the success of B cell deple-tion therapy by using monoclonal antibodies against CD20 further emphasized the importance of B cells in the pathogenesis of RA [Páez M-C, Gómez LM, Anaya J-M. Functional implications of B lymphocytes in the development of reumatoide arthritis. MedUNAB 2006; 9:34-44]
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga UNABspa
dc.identifier.issn2382-4603
dc.identifier.issn0123-7047
dc.identifier.repourlrepourl:https://repository.unab.edu.co
dc.identifier.urihttp://hdl.handle.net/20.500.12749/10402
dc.language.isospaspa
dc.publisherUniversidad Autónoma de Bucaramanga UNAB
dc.publisher.facultyFacultad Ciencias de la Salud
dc.publisher.programPregrado Medicina
dc.relationhttps://revistas.unab.edu.co/index.php/medunab/article/view/167/152
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dc.relation.urihttps://revistas.unab.edu.co/index.php/medunab/article/view/167
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localhttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.sourceMedUNAB; Vol. 9 Núm. 1 (2006): Linfocitos B, Mortalidad Evitable, Trastornos del sueño; 34-44
dc.subjectCiencias médicas
dc.subjectInnovaciones en salud
dc.subjectInvestigaciones
dc.subject.keywordsHealth Scienceseng
dc.subject.keywordsMedicineeng
dc.subject.keywordsMedical Scienceseng
dc.subject.keywordsBiomedical Scienceseng
dc.subject.keywordsLife Scienceseng
dc.subject.keywordsInnovations in healtheng
dc.subject.keywordsResearcheng
dc.subject.keywordsB cells
dc.subject.keywordsRheumatoid arthritis
dc.subject.keywordsRheumatoid factor
dc.subject.keywordsAnti-cyclic citrullinated peptide antibodies (Anti-CCP)
dc.subject.keywordsBAFF
dc.subject.keywordsAnti-CD20
dc.subject.lembCiencias de la salud
dc.subject.lembMedicina
dc.subject.lembCiencias biomédicas
dc.subject.lembCiencias de la vida
dc.subject.proposalLinfocitos B
dc.subject.proposalArtritis reumatoide
dc.subject.proposalFactor reumatoide
dc.subject.proposalAnticuerpos anti-péptidos cíclicos citrulinados (Anti-CCP)
dc.subject.proposalBAFF
dc.subject.proposalAnticuerpos anti-CD20
dc.titleImplicaciones funcionales de los linfocitos B en el desarrollo de la artritis reumatoide
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversionInfo:eu-repo/semantics/publishedVersion
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localArtículospa
dc.type.redcolhttp://purl.org/redcol/resource_type/ART

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