Kisspeptina: un posible blanco terapéutico para Diabetes Mellitus tipo 2

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dc.contributor.authorOsma Serrano, María Juliana
dc.contributor.authorPérez Rodríguez, Carlos Santiago
dc.contributor.authorRojas Pinzón, César David
dc.contributor.cvlacOsma Serrano, María Juliana [0002072508]spa
dc.contributor.orcidOsma Serrano, María Juliana [0000-0003-0740-123X]spa
dc.contributor.researchgroupSemilleros de Investigación UNABspa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialBucaramanga (Santander, Colombia)spa
dc.coverage.temporal2020spa
dc.date.accessioned2023-11-09T09:30:46Z
dc.date.available2023-11-09T09:30:46Z
dc.date.issued2020-11
dc.description.abstractLa kisspeptina es un péptido clave para la regulación del eje hipotalámico-pituitario-gonadal y también participa en la integración de señales metabólicas para permitir las funciones reproductivas. El objetivo es el estudio de las vías de señalización del sistema kisspeptinas y la evaluación de su papel en la Diabetes Mellitus.Se utilizará un cultivo de la línea celular EndoC-ßH1-3 y transfección de KissR en dichas células. Los efectos de KISS1 sobre la secreción de insulina basal e inducida por glucosa de los islotes humanos serán medidos con un ensayo de fosforilación y western blot.spa
dc.description.abstractenglishKisspeptin is a key peptide for the regulation of the hypothalamic-pituitary-gonadal axis and is also involved in the integration of metabolic signals and enabling reproductive functions. The aim of this study is to recognize the role of the signaling pathways of the KP system and the evaluation of its role in Diabetes Mellitus.The EndoC-ßH1-3 cell line and KissR transfection will be used in these cellsThe effects of KISS1 on basal and glucose-induced insulin secretion from human islets will be measured with a phosphorylation assay and western blot.spa
dc.description.learningmodalityModalidad Presencialspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.issnISSN 2344-7079spa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/22682
dc.language.isospaspa
dc.publisher.deparmentSistema de Investigación SIUNABspa
dc.publisher.facultyFacultad Ciencias de la Salud
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programPregrado Medicina
dc.relation.ispartofseriesGeneración Creativa : Encuentro de Semilleros de Investigación UNABspa
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dc.relation.references9. Hirofumi ohga, Sethu selvaraj, Michiya matsuyama. The Roles of Kisspeptin System in the Reproductive Physiology of Fish With Special Reference to Chub Mackerel Studies as Main Axis. Frontiers In Endocrinology. 2018;9(147): 1-15. https://doi.org/10.3389/fendo.2018.00147spa
dc.relation.references10. Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden J, Le Poul E, et al. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6. DOI: 10.1074/jbc.M104847200spa
dc.relation.references11. Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, et al. AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1. J Biol Chem. 2001 Aug 3;276(31):28969-75. DOI: 10.1074/jbc.M102743200spa
dc.relation.references12. Navarro VM. Metabolic regulation of kisspeptin — the link between energy balance and reproduction. Nat Rev Endocrinol. 2020 Aug;16(8):407-20. DOI: 10.1038/s41574-020-0363-7spa
dc.relation.references13. Dudek M, Ziarniak K, Cateau M, Dufourny L, Sliwowska JH. Diabetes Type 2 and Kisspeptin: Central and Peripheral SexSpecific Actions. Trendsin Endocrinology & Metabolism.2019 Nov;30(11):833-43. DOI: https://doi.org/10.1016/j.tem.2019.07.002spa
dc.relation.references14. Lee J, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, et al. KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene. JNCI Journal of the National Cancer Institute. 1996 Dec 4;88(23):1731-7. DOI: 10.1093/jnci/88.23.1731spa
dc.relation.references15. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 2001 May;411(6837):613-7. DOI:10.1038/35079135spa
dc.relation.references16. Hauge-Evans AC, Richardson CC, Milne HM, Christie MR, Persaud SJ, Jones PM. A role for kisspeptin in islet function. Diabetologia. 2006 Sep;49(9):2131-5. DOI: 10.1007/s00125- 006-0343-zspa
dc.relation.references17. Izzi-Engbeaya C, Comninos AN, Clarke SA, Jomard A, Yang L,Jones S, et al. The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans. Diabetes Obes Metab. 2018 Dec;20(12):2800-10. DOI: 10.1111/dom.13460spa
dc.relation.urihttp://hdl.handle.net/20.500.12749/14245
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.sourceOsma, M. J., Pérez, C. S. & Rojas, C. D. (2020). Kisspeptina: un posible blanco terapéutico para Diabetes Mellitus tipo 2. Recuperado de: http://hdl.handle.net/20.500.12749/22682spa
dc.subject.keywordsBasic medical sciencesspa
dc.subject.keywordsKisspeptinsspa
dc.subject.keywordsMellitus diabetesspa
dc.subject.keywordsInvestigationspa
dc.subject.keywordsKISS-1 human proteinspa
dc.subject.keywordsIn vitro techniquespa
dc.subject.keywordsEndoC-βH1spa
dc.subject.keywordsKisspeptin-1 receptorsspa
dc.subject.lembCiencias médicas básicasspa
dc.subject.lembKisspeptinasspa
dc.subject.lembDiabetes mellitusspa
dc.subject.lembInvestigaciónspa
dc.subject.proposalKISS-1 proteína humanspa
dc.subject.proposalTécnica in vitrospa
dc.subject.proposalEndoC-βH1spa
dc.subject.proposalReceptores de Kisspeptina-1spa
dc.titleKisspeptina: un posible blanco terapéutico para Diabetes Mellitus tipo 2spa
dc.title.translatedKisspeptin: a possible therapeutic target for Type 2 Diabetes Mellitusspa
dc.typeConferenceeng
dc.type.coarhttp://purl.org/coar/resource_type/c_f744
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/conferenceProceedingsspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localMemoria de eventosspa
dc.type.redcolhttp://purl.org/redcol/resource_type/EC_AC

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