Resultados funcionales y anatómicos en pacientes con desprendimiento de retina regmatógeno macula-on vs macula-off en Centro Oftalmológico de Cuarto Nivel del Nororiente Colombiano

dc.contributor.advisorRangel Gualdrón, Carlos Mario
dc.contributor.advisorArias Gómez, Alejandro
dc.contributor.advisorVillamizar Portilla, Sylvia Juliana
dc.contributor.apolounabRangel Gualdrón, Carlos Mario [carlos-mario-rangel-gualdron]spa
dc.contributor.apolounabVillamizar Portilla, Sylvia Juliana [sylvia-juliana-villamizar-portilla]spa
dc.contributor.authorQuintero Lizcano, Karol Andrea
dc.contributor.cvlacRangel Gualdrón, Carlos Mario [0001473995]spa
dc.contributor.cvlacVillamizar Portilla, Sylvia Juliana [0000089092]spa
dc.contributor.googlescholarVillamizar Portilla, Sylvia Juliana [es&oi=ao]spa
dc.contributor.orcidQuintero Lizcano, Karol [0000-0002-2839-4801]spa
dc.contributor.orcidRangel Gualdrón, Carlos Mario [0000-0002-6198-0503]spa
dc.contributor.orcidVillamizar Portilla, Sylvia Juliana [0000-0002-7296-3522]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialBucaramanga (Santander, Colombia)spa
dc.coverage.temporalEnero 2016 a diciembre 2021spa
dc.date.accessioned2024-01-22T13:04:48Z
dc.date.available2024-01-22T13:04:48Z
dc.date.issued2023-11-08
dc.degree.nameEspecialista en Oftalmologíaspa
dc.description.abstractEl desprendimiento de retina regmatógeno se da cuando hay una separación entre la retina neurosensorial y el epitelio pigmentario de la retina secundario a una ruptura en la retina. El desprendimiento macular se ha identificado como un indicador importante de mal pronóstico para la recuperación visual en estos pacientes y de manera clásica se ha considerado una posible ventana de 7 a 10 días, sin embargo, existe evidencia en la literatura de que una ventana de máximo 72 horas podría asociarse a mejores desenlaces visuales. Se han realizado estudios retrospectivos previos en otros centros que analizan desenlaces visuales y funcionales en estos pacientes, sin embargo, no se ha realizado ningún estudio como este en nuestra población. El objetivo de este estudio es comparar los resultados anatómicos y funcionales en pacientes con desprendimiento de retina regmatógeno macula-on vs macula-off en un centro oftalmológico de cuarto nivel del nororiente colombiano desde enero del 2016 a diciembre del 2021. Se realizó un análisis de datos secundarios anonimizados de una base de datos del servicio de oftalmología del centro oftalmológico Virgilio Galvis de los pacientes con diagnóstico de desprendimiento de retina regmatógeno atendidos desde enero del 2016 a diciembre del 2021. Adicionalmente se realizó un análisis bivariado con un T de Student pareado para estimar la diferencia de medias en el grupo de macula ON y macula OFF en las variables de agudeza visual mejor corregida preoperatoria y final; y una medida de asociación de OR crudos entre el grupo de AV final mejor corregida peor a 20/30 y el grupo de AV final mejor corregida mejor o igual a 20/30 con múltiples variables independientes, posteriormente las variables significativas en el modelo bivariado se ingresaron al modelo multivariado. Esperamos a través de este estudio poder caracterizar la población de estudio y evaluar si es posible definir una ventana de manejo que genere ajustes en los protocolos de manejo de nuestra institución.spa
dc.description.abstractenglishRhegmatogenous retinal detachment occurs when there is a separation between the neurosensory retina and the retinal pigment epithelium secondary to a break in the retina. Macular detachment has been identified as an important indicator of poor prognosis for visual recovery in these patients and classically, a possible window of 7 to 10 days has been considered, however, there is evidence in the literature that a window of maximum 72 hours could be associated with better visual outcomes. Retrospective studies carried out previously in other centers analyze visual and functional outcomes in these patients, however, no study like this has been performed in our population. The objective of this study is to compare anatomical and functional outcomes in patients with rhegmatogenous retinal detachment macula-on vs macula-off in a fourth level ophthalmological center in northeastern Colombia from January 2016 to December 2021. An analysis of anonymized secondary data was carried out from a database of data from the ophthalmology service of the Virgilio Galvis ophthalmological center of patients with a diagnosis of rhegmatogenous retinal detachment treated from January 2016 to December 2021. Plus performed a bivariate analysis with a paired Student's T to estimate the difference in means in the group of macula ON and macula OFF in the preoperative and final best-corrected visual acuity variables; and a measure of association of crude ORs between the group with the best corrected final VA worse than 20/30 and the group with the best final VA corrected better than or equal to 20/30 with multiple independent variables, then the significant variables in the bivariate model were entered into the multivariate model. We hope through this study to be able characterize the study population and evaluate if it is possible to define a management window that generates adjustments in the management protocols of our institution.spa
dc.description.degreelevelEspecializaciónspa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontents1. Resumen 5 2. Planteamiento del problema y justificación 6 3. Objetivo 7 3.1. Objetivo general 7 3.2. Objetivos específicos 7 4. Marco teórico 7 5. Estado del arte 13 6. Metodología 15 6.1. Diseño 15 6.2. Población, muestra y muestreo 15 6.3. Cálculo de tamaño de muestra 16 6.4. Criterios de elegibilidad 16 6.5. Variables (Tabla de operacionalización de variables) 17 6.6. Descripción de procedimientos 29 6.7. Depuración de datos y plan de análisis 29 7. Resultados / Productos esperados y potenciales beneficiarios 30 8. Consideraciones éticas 32 9. Resultados 33 10. Discusión 40 11. Conclusiones 43 12. Referencias bibliográficas 44 13. Anexos: Cronograma de actividades y presupuesto 48spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/23212
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programEspecialización en Oftalmologíaspa
dc.relation.references1. KangHK,LuffAJ.Managementofretinaldetachment:aguidefornon-ophthalmologists.BMJ.2008May 31;336(7655):1235–40.spa
dc.relation.references2. MitryD,CharterisDG,FleckBW,CampbellH,SinghJ.Theepidemiologyofrhegmatogenousretinal detachment:geographicalvariationandclinicalassociations.BrJOphthalmol.2010Jun;94(6):678–84.spa
dc.relation.references3. LiJQ,WelchowskiT,SchmidM,HolzFG,FingerRP. IncidenceofRhegmatogenousRetinalDetachment in Europe-ASystematicReviewandMeta-Analysis.Ophthalmologica.2019Jun21;242(2):81–6.spa
dc.relation.references4. FraserS,SteelD.Retinaldetachment.BMJClinEvid[Internet].2010Nov24;2010.Availablefrom: https://www.ncbi.nlm.nih.gov/pubmed/21406128spa
dc.relation.references5. TingDSW,FooVHX,TanTE,SieNM,WongCW,TsaiASH,etal.25-yearsTrendsandRiskfactorsrelatedto SurgicalOutcomesofGiantRetinalTear-RhegmatogenousRetinalDetachments.SciRep.2020Mar 25;10(1):5474.spa
dc.relation.references6. BegajT,MarmalidouA,PapakostasTD,DiazJD,KimLA,WuDM,etal.Outcomesofprimary rhegmatogenousretinaldetachmentrepairwithextensivescleral-depressedvitreousremovalanddynamic examination.PLoSOne.2020Sep24;15(9):e0239138.spa
dc.relation.references7. WilkinsonCP.Mysteriesregardingthesurgicallyreattachedretina.TransAmOphthalmolSoc.2009 Dec;107:55–7.spa
dc.relation.references8. FringsA,MarkauN,KatzT,StemplewitzB,SkevasC,DruchkivV,etal.Visual recoveryafterretinal detachmentwithmacula-off: issurgerywithinthefirst72hbetterthanafter?BrJOphthalmol.2016 Nov;100(11):1466–9.spa
dc.relation.references9. vanBusselEM,vanderValkR,BijlsmaWR,LaHeijEC. Impactofdurationofmacula-offretinaldetachment onvisualoutcome:asystematicreviewandmeta-analysisof literature.Retina.2014Oct;34(10):1917–25.spa
dc.relation.references10. CookB,LewisGP,FisherSK,AdlerR.Apoptoticphotoreceptordegenerationinexperimental retinal detachment. InvestOphthalmolVisSci.1995May;36(6):990–6.spa
dc.relation.references11. HisatomiT,SakamotoT,GotoY,YamanakaI,OshimaY,HataY,etal.Critical roleofphotoreceptorapoptosis infunctionaldamageafterretinaldetachment.CurrEyeRes.2002Mar;24(3):161–72.spa
dc.relation.references12. ArroyoJG,YangL,BulaD,ChenDF.Photoreceptorapoptosisinhumanretinaldetachment.AmJOphthalmol. 2005Apr;139(4):605–10.spa
dc.relation.references13. HassanTS,SarrafizadehR,RubyAJ,GarretsonBR,KuczynskiB,WilliamsGA.Theeffectofdurationof maculardetachmentonresultsafterthescleralbucklerepairofprimary,macula-offretinaldetachments. Ophthalmology.2002Jan;109(1):146–52spa
dc.relation.references14. NemetA,MoshiriA,YiuG,LoewensteinA,MoisseievE.AReviewof InnovationsinRhegmatogenousRetinal DetachmentSurgicalTechniques.JOphthalmol.2017May7;2017:4310643.spa
dc.relation.references15. SultanZN,AgorogiannisEI, IannettaD,SteelD,SandinhaT.Rhegmatogenousretinaldetachment:areviewof currentpracticeindiagnosisandmanagement.BMJOpenOphthalmol.2020Oct9;5(1):e000474.spa
dc.relation.references16. GloorBP,MarmorMF.Controversyovertheetiologyandtherapyofretinaldetachment: thestrugglesofJules Gonin.SurvOphthalmol.2013Mar-Apr;58(2):184–95.spa
dc.relation.references17. FineSL,GoldbergMF,TasmanW.HistoricalPerspectivesontheManagementofMacularDegeneration, DiabeticRetinopathy,andRetinalDetachment:PersonalReminiscences.Ophthalmology.2016 Oct;123(10S):S64–77.spa
dc.relation.references18. SebagJ.Vitreous: inHealthandDisease.Springer;2014.925pspa
dc.relation.references19. MitryD,FleckBW,WrightAF,CampbellH,CharterisDG.Pathogenesisofrhegmatogenousretinal detachment:predisposinganatomyandcellbiology.Retina.2010Nov-Dec;30(10):1561–72.spa
dc.relation.references20. FeltgenN,HeimannH,HoeraufH,WalterP,HilgersRD,HeussenN,etal.Scleralbucklingversusprimary vitrectomyinrhegmatogenousretinaldetachmentstudy(SPRstudy):Riskassessmentofanatomicaloutcome. SPRstudyreportno.7.ActaOphthalmol.2013May;91(3):282–7.spa
dc.relation.references21. MitryD,ChalmersJ,AndersonK,WilliamsL,FleckBW,WrightA,etal.Temporal trendsinretinaldetachment incidenceinScotlandbetween1987and2006.BrJOphthalmol.2011Mar;95(3):365–9.spa
dc.relation.references22. VangipuramG,LiC,LiS,LiuL,HarrisonLD,LumF,etal.TimingofDelayedRetinalPathologyinPatients PresentingwithAcutePosteriorVitreousDetachment intheIRIS®Registry(IntelligentResearchinSight). OphthalmolRetina.2023Aug;7(8):713–20.spa
dc.relation.references23. Riskfactorsfor idiopathicrhegmatogenousretinaldetachment.TheEyeDiseaseCase-ControlStudyGroup. AmJEpidemiol.1993Apr1;137(7):749–57.spa
dc.relation.references23. Riskfactorsfor idiopathicrhegmatogenousretinaldetachment.TheEyeDiseaseCase-ControlStudyGroup. AmJEpidemiol.1993Apr1;137(7):749–57.spa
dc.relation.references25. QureshiMH,SteelDHW.Correction:Retinaldetachment followingcataractphacoemulsification-areviewof the literature.Eye.2020Apr;34(4):787.spa
dc.relation.references26. FeltgenN,WalterP.Rhegmatogenousretinaldetachment--anophthalmologicemergency.DtschArztebl Int. 2014Jan6;111(1-2):12–21;quiz22spa
dc.relation.references27. D’AmicoDJ.Clinicalpractice.Primaryretinaldetachment.NEnglJMed.2008Nov27;359(22):2346–54.spa
dc.relation.references28. HeimannH,Bartz-SchmidtKU,BornfeldN,WeissC,HilgersRD,FoersterMH,etal.Scleralbucklingversus primaryvitrectomyinrhegmatogenousretinaldetachment:aprospectiverandomizedmulticenterclinicalstudy. Ophthalmology.2007Dec;114(12):2142–54.spa
dc.relation.references28. HeimannH,Bartz-SchmidtKU,BornfeldN,WeissC,HilgersRD,FoersterMH,etal.Scleralbucklingversus primaryvitrectomyinrhegmatogenousretinaldetachment:aprospectiverandomizedmulticenterclinicalstudy. Ophthalmology.2007Dec;114(12):2142–54.spa
dc.relation.references30. SchepensCL,OkamuraID,BrockhurstRJ.Thescleralbucklingprocedures. I.Surgical techniquesand management.AMAArchOphthalmol.1957Dec;58(6):797–811.spa
dc.relation.references31. SabatesWI,AbramsGW,SwansonDE,NortonEW.Theuseof intraoculargases.Theresultsofsulfur hexafluoridegasinretinaldetachmentsurgery.Ophthalmology.1981May;88(5):447–54.spa
dc.relation.references32. MachemerR,ParelJM,BuettnerH.Anewconcept forvitreoussurgery. I. Instrumentation.AmJOphthalmol. 1972Jan;73(1):1–7spa
dc.relation.references33. VaziriK,SchwartzSG,KishorKS,FlynnHWJr.Tamponadeinthesurgicalmanagementofretinaldetachment. ClinOphthalmol.2016Mar16;10:471–6.spa
dc.relation.references34. BarcaF,CaporossiT,RizzoS.Siliconeoil:differentphysicalproprietiesandclinicalapplications.BiomedRes Int.2014Jun11;2014:502143.spa
dc.relation.references35. WilliamsonTH,LeeEJK,ShunmugamM.Characteristicsofrhegmatogenousretinaldetachmentandtheir relationshiptosuccessratesofsurgery.Retina.2014Jul;34(7):1421–7.spa
dc.relation.references36. BrazitikosPD,AndroudiS,ChristenWG,StangosNT.Primaryparsplanavitrectomyversusscleralbuckle surgeryforthetreatmentofpseudophakicretinaldetachment:arandomizedclinical trial.Retina.2005 Dec;25(8):957–64.spa
dc.relation.references37. WarrenA,WangDW,LimJI.Rhegmatogenousretinaldetachmentsurgery:Areview.ClinExperiment Ophthalmol.2023Apr;51(3):271–9.spa
dc.relation.references38. ElghawyO,DuongR,NigussieA,BogaardJD,PatrieJ,ShildkrotY.Effectofsurgical timingin23-gparsplana vitrectomyforprimaryrepairofmacula-offrhegmatogenousretinaldetachment,aretrospectivestudy.BMC Ophthalmol.2022Mar25;22(1):136.spa
dc.relation.references39. VeithM,StranakZ,PencakM,VranovaJ,StudenyP.25-gaugevitrectomyandgasforthemanagementof rhegmatogenousretinaldetachment.BiomedPapMedFacUnivPalackyOlomoucCzechRepub.2019 Feb;163(1):80–4.spa
dc.relation.references40. LeeSH,HanJW,ByeonSH,KimSS,KohHJ,LeeSC,etal.RETINALLAYERSEGMENTATIONAFTER SILICONEOILORGASTAMPONADEFORMACULA-ONRETINALDETACHMENTUSINGOPTICAL COHERENCETOMOGRAPHY.Retina.2018Feb;38(2):310–9.spa
dc.relation.references41. ParkDH,ChoiKS,SunHJ,LeeSJ.FACTORSASSOCIATEDWITHVISUALOUTCOMEAFTER MACULA-OFFRHEGMATOGENOUSRETINALDETACHMENTSURGERY.Retina.2018Jan;38(1):137–47.spa
dc.relation.references42. KangHM,LeeSC,LeeCS.AssociationofSpectral-DomainOpticalCoherenceTomographyFindingswith VisualOutcomeofMacula-OffRhegmatogenousRetinalDetachmentSurgery.Ophthalmologica.2015May 13;234(2):83–90.spa
dc.relation.references43. MahmoudiS,AlmonyA.Macula-SparingRhegmatogenousRetinalDetachment: IsEmergentSurgery Necessary?JOphthalmicVisRes.2016Jan-Mar;11(1):100–7spa
dc.relation.references44. YorstonD,DonachiePHJ,LaidlawDA,SteelDH,SparrowJM,AylwardGW,etal.Factorsaffectingvisual recoveryaftersuccessful repairofmacula-offretinaldetachments: findingsfromalargeprospectiveUKcohort study.Eye.2021May;35(5):1431–9.spa
dc.relation.references45. MalosseL,RousseauH,BaumannC,AngioiK,LeroyB,SennlaubF,etal.Prevalenceandriskfactorsfor outerretinal layerdamageaftermacula-offretinaldetachment.BrJOphthalmol.2020May;104(5):660–5.spa
dc.relation.references46. LewisGP,CharterisDG,SethiCS,LeitnerWP,LinbergKA,FisherSK.Theabilityofrapidretinal reattachment tostoporreversethecellularandmoleculareventsinitiatedbydetachment. InvestOphthalmolVisSci.2002 Jul;43(7):2412–20.spa
dc.relation.references47. WilliamsonTH,ShunmugamM,RodriguesI,DogramaciM,LeeE.Characteristicsofrhegmatogenousretinal detachmentandtheirrelationshiptovisualoutcome.Eye.2013Sep;27(9):1063–9.spa
dc.relation.references48. UgarteM,WilliamsonTH.Horizontalandverticalmicropsiafollowingmacula-offrhegmatogenous retinal-detachmentsurgical repair.GraefesArchClinExpOphthalmol.2006Nov;244(11):1545–8.spa
dc.relation.references49. TaniP,RobertsonDM,LangworthyA.Prognosisforcentralvisionandanatomicreattachment in rhegmatogenousretinaldetachmentwithmaculadetached.AmJOphthalmol.1981Nov;92(5):611–20.spa
dc.relation.references50. WolfensbergerTJ,GonversM.Opticalcoherencetomographyintheevaluationof incompletevisualacuity recoveryaftermacula-offretinaldetachments.GraefesArchClinExpOphthalmol.2002Feb;240(2):85–9.spa
dc.relation.references51. RossWH.Visual recoveryaftermacula-offretinaldetachment.Eye.2002Jul;16(4):440–6.spa
dc.relation.references52. Chatziralli I,ChatzirallisA,KazantzisD,DimitriouE,MachairoudiaG,TheodossiadisG,etal.Predictive FactorsforLong-TermPostoperativeVisualOutcomeinPatientswithMacula-OffRhegmatogenousRetinal DetachmentTreatedwithVitrectomy.Ophthalmologica.2021Jan19;244(3):213–7.spa
dc.relation.references53. DiederenRMH,LaHeijEC,KesselsAGH,GoezinneF,LiemATA,HendrikseF.Scleralbucklingsurgeryafter macula-offretinaldetachment:worsevisualoutcomeaftermorethan6days.Ophthalmology.2007 Apr;114(4):705–9.spa
dc.relation.references54. GrevenMA,LengT,SilvaRA,LeungLSB,KarthPA,MoshfeghiDM,etal.Reductionsinfinalvisualacuityoccurevenwithinthefirst3daysafteramacula-offretinaldetachment.BrJOphthalmol. 2019Oct;103(10):1503–6.spa
dc.relation.references55. NgH,LaHeijEC,vanMeursJC.Thedurationofmaculardetachment inretinaldetachment isdifficult to determine.ActaOphthalmol.2020May;98(3):e396–7.spa
dc.relation.references56. QuintynJC,BenouaichX,Pagot-MathisV,MathisA.Retinaldetachment,aconditionlittleknowntopatients. Retina.2006Nov-Dec;26(9):1077–8.spa
dc.relation.references57. HikichiT,YoshidaA.Timecourseofdevelopmentofposteriorvitreousdetachment inthefelloweyeafter development inthefirsteye.Ophthalmology.2004Sep;111(9):1705–7.spa
dc.relation.references58. TannerV,HarleD,TanJ,FooteB,WilliamsonTH,ChignellAH.Acuteposteriorvitreousdetachment: the predictivevalueofvitreouspigmentandsymptomatology.BrJOphthalmol.2000Nov;84(11):1264–8.spa
dc.relation.references59. ShunmugamM,ShahAN,HysiPG,WilliamsonTH.Thepatternanddistributionofretinalbreaksineyeswith rhegmatogenousretinaldetachment.AmJOphthalmol.2014Jan;157(1):221–6.e1.spa
dc.relation.references60. QuevedoMÁ.Alteracionesvitreorretinianaspredisponentesaldesprendimientoderetina:guíadetratamiento. EditorialGlosa,S.L.;2008.149pspa
dc.relation.references61. SERV.ManualderetinaSERV.ElsevierEspaña;2013.344p.spa
dc.relation.references62. LeeCS,ShaverK,YunSH,KimD,WenS,GhorayebG.Comparisonof thevisualoutcomebetween macula-onandmacula-offrhegmatogenousretinaldetachmentbasedonthedurationofmaculardetachment. BMJOpenOphthalmol.2021Mar11;6(1):e000615.spa
dc.relation.references63. DiLauroS,CastrejónM,FernándezI,RojasJ,CocoRM,SanabriaMR,etal.LossofVisualAcuityafter SuccessfulSurgeryforMacula-OnRhegmatogenousRetinalDetachment inaProspectiveMulticentreStudy.J Ophthalmol.2015Nov12;2015:821864.spa
dc.relation.references64. GuptaOP,BensonWE.Theriskof felloweyesinpatientswithrhegmatogenousretinaldetachment.CurrOpin Ophthalmol.2005Jun;16(3):175–8.spa
dc.relation.references65. GonzalesCR,GuptaA,SchwartzSD,KreigerAE.Thefelloweyeofpatientswithrhegmatogenousretinal detachment.Ophthalmology.2004Mar;111(3):518–21.spa
dc.relation.uriapolohttps://apolo.unab.edu.co/en/persons/carlos-mario-rangel-gualdronspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsHealth sciencesspa
dc.subject.keywordsOphthalmologyspa
dc.subject.keywordsRetinal detachmentspa
dc.subject.keywordsMaculaspa
dc.subject.keywordsRetinal diseasesspa
dc.subject.keywordsRetinal degenerationspa
dc.subject.keywordsDemographyspa
dc.subject.keywordsVisual acuityspa
dc.subject.lembOftalmologíaspa
dc.subject.lembCiencias médicasspa
dc.subject.lembEnfermedades de la retinaspa
dc.subject.lembDegeneración retinianaspa
dc.subject.lembDemografíaspa
dc.subject.lembAgudeza visualspa
dc.subject.proposalCiencias de la saludspa
dc.subject.proposalDesprendimiento de retinaspa
dc.subject.proposalMaculaspa
dc.titleResultados funcionales y anatómicos en pacientes con desprendimiento de retina regmatógeno macula-on vs macula-off en Centro Oftalmológico de Cuarto Nivel del Nororiente Colombianospa
dc.title.translatedFunctional and anatomical results in patients with macula on vs macula off rhegmatogenous retinal detachment in fourth level ophthalmology center in northeast colombiaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.redcolhttp://purl.org/redcol/resource_type/TM

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