Beneficios del uso del hierro parenteral como alternativa eficaz en el manejo de la anemia gestacional en Colombia

dc.contributor.authorOrtiz Serrano, Ricardo
dc.contributor.authorLeal Berna, Juliana
dc.contributor.authorLópez Acevedo, Andrea Valentina
dc.contributor.authorMartínez Maldonado, Eddy Gabriela
dc.contributor.authorMejía Rodríguez, Paula Andrea
dc.date.accessioned2024-08-15T14:44:42Z
dc.date.available2024-08-15T14:44:42Z
dc.date.issued2022-06-23
dc.description.abstractLa Organización Mundial de la Salud (OMS) estima que más del 40% de las mujeres embarazadas a nivel mundial tienen anemia, y la mitad de estas padecen deficiencia de hierro. La prevalencia en América Latina es del 40% y en Colombia del 44.7%. Fisiológicamente en el embarazo se produce una mal llamada “anemia dilucional”, existen condiciones en la embarazada que la predisponen a tener una anemia patológica. Esta última es causada principalmente por un déficit de hierro, de allí la importancia de diagnosticar a tiempo esta entidad e iniciar el manejo. La administración de hierro es la base del tratamiento de la anemia por deficiencia de hierro. Puede ser administrado por vía oral, la cual es la preferida en la mayoría de las pacientes; sin embargo, cuando este no es posible administrarlo, es esencial recurrir al hierro parenteral. No obstante, el hierro parenteral es poco usado como primera línea en el manejo de la anemia gestacional. El presente artículo tiene como objetivo realizar una revisión que permita identificar la terapia con hierro parenteral como una alternativa eficaz de manejo para la anemia gestacional, teniendo en cuenta las características farmacológicas, la administración y el uso entre las diferentes moléculas disponibles en Colombia. Metodología. Corresponde a un estudio de revisión de literatura en bases de datos y bibliotecas electrónicas, los criterios que se tuvieron en cuenta fueron textos publicados entre 1996 y 2020, en español e inglés. Se obtuvo un resultado de 95 artículos, de los cuales se seleccionaron 49. Las palabras clave para su búsqueda fueron fisiología, hierro parenteral, anemia gestacional, déficit de hierro, complicaciones del embarazo, compuestos de hierro, farmacocinética, diagnóstico y tratamiento. División de temas tratados. Fisiología; ayudas diagnósticas; características farmacológicas del hierro parenteral; ventajas, indicaciones y contraindicaciones del hierro parenteral; efectos secundarios y forma de aplicación. Conclusiones. El hierro parenteral es un tratamiento seguro y eficaz para manejar la anemia en el embarazo, se debe tener en cuenta las indicaciones y la farmacología de las moléculas para elegir la más adecuada. Además, repone más rápidamente las reservas de hierro y los niveles de hemoglobina.spa
dc.description.abstractenglishThe World Health Organization (WHO) estimates that more than 40% of pregnant women worldwide have anemia, and that half of them suffer from iron deficiency. The prevalence of this in Latin America is 40%, and in Colombia, 44.7%. Physiologically, a problem called “dilutional anemia” occurs during pregnancy. There are conditions in pregnant women that predispose them to suffering from pathological anemia. The latter is mainly caused by iron deficiency, hence the importance of diagnosing this entity on time and starting treatment. Iron administration is the basis of treatment of anemia caused by iron deficiency. It can be administered orally, which is the preferred option in the majority of patients. However, when this is not possible, parenteral iron must be used. However, parenteral iron is rarely used as the first line of treatment of gestational anemia. The objective of this article is to carry out a review that allows for the identification of therapy with parenteral iron as an efficient alternative for the treatment for gestational anemia, considering the pharmacological characteristics, administration, and use among the different molecules available in Colombia. Methodology. We carried out a search in databases and electronic libraries. The criteria considered were texts published between 1996 and 2020 in Spanish and English. 95 articles were obtained, of which 49 were selected. The keywords for their search were physiology, parenteral iron, gestational anemia, iron deficit, pregnancy complications, iron compounds, pharmacokinetics, diagnosis, and treatment. Division of Covered Topics. Physiology; diagnostic aids; pharmacological characteristics of parenteral iron; advantages, indications, and contraindications of parenteral iron; secondary effects and application method. Conclusions. Parenteral iron is a safe and efficient treatment to handle anemia during pregnancy. The indications and pharmacology of the molecules must be considered to choose the most appropriate option. In addition, it replaces iron reserves and hemoglobin levels more quickly.eng
dc.description.abstractotherA Organização Mundial de Saúde (OMS) estima que mais de 40% das mulheres grávidas em todo o mundo são anêmicas, e metade delas sofre de deficiência de ferro. A prevalência na América Latina é de 40% e na Colômbia de 44.7%. Fisiologicamente na gravidez ocorre a chamada “anemia dilucional”, e existem condições na gestante que a predispõem a ter uma anemia patológica. Esta última é causada principalmente por deficiência de ferro, daí a importância de diagnosticar esta entidade a tempo e iniciar o manejo. A administração de ferro é a base do tratamento da anemia por deficiência de ferro. Pode ser administrado por via oral, o que é preferido pela maioria das pacientes; porém, quando não for possível administrá-lo dessa forma, é imprescindível recorrer ao ferro parenteral. No entanto, o ferro parenteral é raramente usado como primeira linha no manejo da anemia gestacional. O objetivo deste artigo é realizar uma revisão que permita identificar a terapia com ferro parenteral como uma alternativa eficaz de tratamento da anemia gestacional, levando em consideração as características farmacológicas, administração e uso entre as diferentes moléculas disponíveis na Colômbia. Metodologia. Foi realizada uma busca em bases de dados e bibliotecas eletrônicas, os critérios levados em consideração foram textos publicados entre 1996 e 2020, em espanhol e inglês. Foi obtido um total de 95 artigos, dos quais 49 foram selecionados. As palavras-chave para a busca foram fisiologia, ferro parenteral, anemia gestacional, deficiência de ferro, complicações na gravidez, compostos de ferro, farmacocinética, diagnóstico e tratamento. Divisão dos temas abordados. Fisiologia; auxiliares de diagnóstico; características farmacológicas do ferro parenteral; vantagens, indicações e contraindicações do ferro parenteral; efeitos colaterais e método de aplicação. Conclusões. O ferro parenteral é um tratamento seguro e eficaz para o manejo da anemia na gravidez, as indicações e farmacologia das moléculas devem ser levadas em consideração a fim de escolher a mais adequada. Além disso, reabastece mais rapidamente as reservas de ferro e os níveis de hemoglobina.por
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.29375/01237047.3966
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga UNABspa
dc.identifier.issni-ISSN 0123-7047spa
dc.identifier.issne-ISSN 2382-4603spa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/26041
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.relationhttps://revistas.unab.edu.co/index.php/medunab/article/view/3966/3634spa
dc.relation.referencesAmerican College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 95: Anemia in Pregnancy. Obstet Gynecol [Internet]. 2008;112(1):201-7. doi: https://doi.org/10.1097/AOG.0b013e3181809c0d
dc.relation.referencesSmith C, Teng F, Branch E, Chu S, Joseph KS. Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy. Obstet Gynecol [Internet]. 2019;134(6):1234-44. doi: https://doi.org/10.1097/ AOG.0000000000003557
dc.relation.referencesWorld Health Organization. Maternal health. [Internet] Ginebra: WHO; 2022 [citado 29 de junio de 2022]. Recuperado a partir de: https://www.who.int/healthtopics/ maternal-health#tab=tab_1
dc.relation.referencesWorld Health Organization. Antenatal iron supplementation. [Internet]. Ginebra: WHO; 2022 [citado 29 de junio de 2022]. Recuperado a partir de: https://www.who.int/data/nutrition/nlis/info/antenataliron- supplementation.
dc.relation.referencesLee AI, Okam MM. Anemia in pregnancy. Hematol Oncol Clin N Am [Internet]. 2011;25(2):241-59. doi: https://doi.org/10.1016/j.hoc.2011.02.001.
dc.relation.referencesBecerra C, Gonzáles GF, Villena A, de la Cruz D, Florián A. Prevalencia de anemia en gestantes, Hospital Regional de Pucallpa, Perú. Rev Panam Salud Pública [Internet]. 1998;3(5):285-92. doi: https://doi. org/10.1590/S1020-49891998000500001
dc.relation.referencesRincón-Pabón D, Urazán-Hernández Y, González- Santamaría J. Prevalencia y factores sociodemográficos asociados a anemia ferropénica en mujeres gestantes de Colombia (análisis secundario de la ENSIN 2010). Nutr Hosp [Internet]. 2019;36(1):87-95. doi: https://doi. org/10.20960/nh.1895
dc.relation.referencesInstituto Colombiano de Bienestar Familiar. ENSIN: Encuesta Nacional de Situación Nutricional [Internet]. ICBF. [citado 2 de enero de 2021]. Recuperado a partir de: https://www.icbf.gov.co/bienestar/nutricion/ encuesta-nacional-situacion-nutricional
dc.relation.referencesGómez-Sánchez PI, Arévalo-Rodríguez I, Rubio- Romero JA, Amaya-Guío J, Osorio-Castaño JH, Buitrago-Gutiérrez G, et al. Guías de Práctica Clínica para la prevención, detección temprana y tratamiento de las complicaciones del embarazo, parto o puerperio: introducción y metodología. Rev Colomb Obstet Ginecol [Internet]. 2013;64(3):234-4. doi: https://doi. org/10.18597/rcog.105
dc.relation.referencesEspitia-De La Hoz F, Orozco-Santiago L. Anemia en el embarazo, un problema de salud que puede prevenirse. Médicas UIS [Internet]. 2013;26(3):45- 50. Recuperado a partir de: https://revistas.uis.edu. co/index.php/revistamedicasuis/article/view/3920
dc.relation.referencesVilalba-Cerquera YF, Vanegas-Torres SV, Pérez ML, Peralta MM, Rivera JD, Galindo JD, et al. Caracterización de la población con anemia en el embarazo y su asociación con la morbimortalidad perinatal. Rev Méd de Risaralda [Internet]. 2019;25(1):30-39. doi: https://doi.org/10.22517/253 95203.18441.
dc.relation.referencesBreymann C, Honegger C, Hösli I, Surbek D. Diagnosis and treatment of iron-deficiency anaemia in pregnancy and postpartum. Arch Gynecol Obstet [Internet]. 2017;296:1229-1234. doi: https://doi. org/10.1007/s00404-017-4526-2.
dc.relation.referencesde Haas S, Ghossein-Doha C, van-Kuijk SMJ, van- Drongelen J, Spaanderman MEA. Physiological adaptation of maternal plasma volume during pregnancy: a systematic review and metaanalysis. Ultrasound Obstet Gynecol [Internet]. 2017;49(2):177-87. doi: https://doi.org/10.1002/ uog.17360
dc.relation.referencesVricella LK. Emerging understanding and measurement of plasma volume expansion in pregnancy. Am J Clin Nutr [Internet]. 2017;106(6):1620S-1625S. doi: https://doi. org/10.3945/ajcn.117.155903
dc.relation.referencesSun D, McLeod A, Gandhi S, Malinowski AK, Shehata N. Anemia in Pregnancy: A Pragmatic Approach. Obstet Gynecol Surv [Internet]. 2017;72(12):730-7. doi: https://doi.org/10.1097/ OGX.0000000000000510
dc.relation.referencesMeans RT. Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters. Nutrients [Internet]. 2020;12(2):447. doi: https://doi. org/10.3390/nu12020447
dc.relation.referencesMilman N. Prepartum anaemia: prevention and treatment. Ann Hematol [Internet]. 2008;87(12):949- 59. doi: https://doi.org/10.1007/s00277-008-0518-4
dc.relation.referencesKalaimani-Rabindrakumar MS, Pujitha- Wickramasinghe V, Gooneratne L, Arambepola C, Senanayake H, Thoradeniya T. The role of haematological indices in predicting early iron deficiency among pregnant women in an urban area of Sri Lanka. BMC Hematol [Internet]. 2018;18-37. doi: https://doi.org/10.1186/s12878-018-0131-2.
dc.relation.referencesMilman N. Fisiopatología e impacto de la deficiencia de hierro y la anemia en las mujeres gestantes y en los recién nacidos/infantes. Rev Perú Ginecol Obstet [Internet]. 2012;58:293-312. doi: https://doi. org/10.31403/rpgo.v58i47
dc.relation.referencesAuerbach M, Adamson JW. How we diagnose and treat iron deficiency anemia. Am J Hematol [Internet]. 2016;91:31-8. doi: https://doi.org/10.1002/ajh.24201
dc.relation.referencesGeisser P, Burckhardt S. The pharmacokinetics and pharmacodynamics of iron preparations. Pharmaceutics [Internet]. 2011;3(1):12-33. doi: https://doi.org/10.3390/pharmaceutics3010012
dc.relation.referencesPavord S, Daru J, Prasannan N, Robinson S, Stanworth S, Girling J, et al. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol [Internet]. 2020;188:819-30. doi: https:// doi.org/10.1111/bjh.16221
dc.relation.referencesGovindappagari S, Burwick RM. Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta- Analysis. Am J Perinatol [Internet]. 2019;36(4):366- 76. doi: https://doi.org/10.1055/s-0038-1668555
dc.relation.referencesBreymann C, Milman N, Mezzacasa A, Bernard R, Dudenhausen J. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP). J Perinat Med [Internet]. 2017;45(4):443-53.doi: https://doi. org/10.1515/jpm-2016-0050
dc.relation.referencesBreymann C. Iron Deficiency and Anaemia in Pregnancy: Modern Aspects of Diagnosis and Therapy. Blood Cells Mol Dis [Internet]. 2002;29(3):506-16. doi: https://doi.org/10.1006/ bcmd.2002.0597
dc.relation.referencesKhalafallah AA, Dennis AE. Iron deficiency anaemia in pregnancy and postpartum: pathophysiology and effect of oral versus intravenous iron therapy. J Pregnancy [Internet]. 2012;630519. doi: https:// doi.org/10.1155/2012/630519
dc.relation.referencesAuerbach M, Landy HJ. Anemia in pregnancy. UpToDate. [Internet]. Recuperado a partir de: h t t p s : / / w w w. u p t o d a t e . c o m / c o n t e n t s / anemia-in-pregnancy?search=ANEMIA%20 I N % 2 0 P R E G N A N C Y & s o u r c e = s e a r c h _ r e s u l t & s e l e c t e d T i t l e = 1 ~ 1 5 0 & u s a g e _ type=default&display_rank=1
dc.relation.referencesCamaschella C. Iron-deficiency anemia. N Engl J Med [Internet]. 2015;372(19):1832-43. doi: https:// doi.org/10.1056/NEJMra1401038
dc.relation.referencesRampton D, Folkersen J, Fishbane S, Hedenus M, Howaldt S, Locatelli F, et al. Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management. Haematologica [Internet]. 2014;99(11):1671-6. doi: https://doi. org/10.3324/haematol.2014.111492
dc.relation.referencesTaylor S, Rampton D. Treatment of iron deficiency anemia: practical considerations. Pol Arch Med Wewn [Internet]. 2015;125(6):452-60. doi: https:// doi.org/10.20452/pamw.2888
dc.relation.referencesBurns DL, Pomposelli JJ. Toxicity of parenteral iron dextran therapy. Kidney Int Suppl [Internet]. 1999;55(69):S119-24. doi: https://doi.org/10.1046/ j.1523-1755.1999.055suppl.69119.x
dc.relation.referencesNational Blood Authority. Iron product choice and dose calculation guide for adults [Internet]. Australia; 2022. [citado 30 de junio de 2022]. Recuperado a partir de: https://www.blood.gov.au/ iron-product-choice-and-dose-calculation-guideadults
dc.relation.referencesEvstatiev R, Marteau P, Iqbal T, Khalif IL, Stein J, Bokemeyer B, et al. FERGIcor, a Randomized Controlled Trial on ferric carboxymaltose for Iron Deficiency Anemia in Inflammatory Bowel Disease. Gastroenterology [Internet]. 2011;141(3):846- 853.e1-2. doi: https://doi.org/10.1053/j. gastro.2011.06.005
dc.relation.referencesAuerbach M, Pappadakis JA, Bahrain H, Auerbach SA, Ballard H, Dahl NV. Safety and efficacy of rapidly administered (one hour) one gram of low molecular weight iron dextran (INFeD) for the treatment of iron deficient anemia. Am J Hematol [Internet]. 2011;86(10):860-2. doi: https://doi. org/10.1002/ajh.22153
dc.relation.referencesOndo WG. Intravenous iron dextran for severe refractory restless legs syndrome. Sleep Med. 2010;11(5):494-6. doi: https://doi.org/10.1016/j. sleep.2009.12.002
dc.relation.referencesÁlvarez Vega DM, Espinosa LA. Guía de práctica clínica (gpc): manejo de anemia en el embarazo y el puerperio en el Hospital Local del Norte – E.S.E. ISABU. 2018.
dc.relation.referencesAuerbach M, Chaudhry M, Goldman H, Ballard H. Value of methylprednisolone in prevention of the arthralgia-myalgia syndrome associated with the total dose infusion of iron dextran: a double blind randomized trial. J Lab Clin Med [Internet]. 1998;131(3):257-60. doi: https://doi.org/10.1016/ s0022-2143(98)90098-1
dc.relation.referencesBager P, Dahlerup JF. The health care cost of intravenous iron treatment in IBD patients depends on the economic evaluation perspective. J Crohns Colitis [Internet]. 2010;4(4):427-30. doi: https://doi. org/10.1016/j.crohns.2010.01.007
dc.relation.referencesWiegersma AM, Dalman C, Lee BK, Karlsson H, Gardner RM. Association of Prenatal Maternal Anemia With Neurodevelopmental Disorders. JAMA Psychiatry [Internet]. 2019;76(12):1294-304. doi: https://doi.org/10.1001/jamapsychiatry.2019.2309
dc.relation.referencesMeinzen-Derr JK, Guerrero ML, Altaye M, Ortega- Gallegos H, Ruiz-Palacios GM, Morrow AL. Risk of infant anemia is associated with exclusive breastfeeding and maternal anemia in a Mexican cohort. J Nutr [Internet]. 2006;136(2):452-8. doi: https://doi. org/10.1093/jn/136.2.452
dc.relation.referencesHenly SJ, Anderson CM, Avery MD, Hills-Bonuyk SG, Potter S, Duckett LJ. Anemia and Insufficient Milk in First-Time Mothers. Birth [Internet]. 1995;22(2):87-92. doi: https://doi.org/10.1111/ j.1523-536x.1995.tb00565.x
dc.relation.referencesBeard JL, Hendricks MK, Perez EM, Murray-Kolb LE, Berg A, Vernon-Feagans L, et al. Maternal iron deficiency anemia affects postpartum emotions and cognition. J Nutr [Internet]. 2005;135(2):267-72. doi: https://doi.org/10.1093/jn/135.2.267
dc.relation.referencesRadhika AG, Sharma AK, Perumal V, Sinha A, Sriganesh V, Kulshreshtha V, et al. Parenteral Versus Oral Iron for Treatment of Iron Deficiency Anaemia During Pregnancy and post-partum: A Systematic Review. J Obstet Gynaecol India [Internet]. 2019;69:13-24. doi: https://doi.org/10.1007/s13224- 018-1191-8
dc.relation.referencesNeogi SB, Devasenapathy N, Singh R, Bhushan H, Shah D, Divakar H, et al. Safety and effectiveness of intravenous iron sucrose versus standard oral iron therapy in pregnant women with moderate-to-severe anaemia in India: a multicentre, open-label, phase 3, randomised, controlled trial. Lancet Glob Health [Internet]. 2019;7(12):e1706-16. doi: https://doi. org/10.1016/S2214-109X(19)30427-9
dc.relation.referencesGilmartin CE, Hoang T, Cutts BA, Leung L. Retrospective cohort study comparing the adverse reactions and efficacy of intravenous iron polymaltose with ferric carboxymaltose for iron deficiency anemia. Int J Gynaecol Obstet [Internet]. 2018;141(3):315-20. doi: https://doi.org/10.1002/ ijgo.12476
dc.relation.referencesCançado RD, Novis-de Figueiredo PO, Olivato MCA, Chiattone CS. Efficacy and safety of intravenous iron sucrose in treating adults with iron deficiency anemia. Rev Bras Hematol Hemoter [Internet]. 2011;33(6):439-43. doi: https://doi. org/10.5581/1516-8484.20110119
dc.relation.referencesZoller H, Schaefer B, Glodny B. Iron-induced hypophosphatemia: an emerging complication. Curr Opin Nephrol Hypertens [Internet]. 2017;26(4):266-75. doi: https://doi.org/10.1097/ MNH.0000000000000329
dc.relation.referencesHuang LL, Lee D, Troster SM, Kent AB, Roberts MA, Macdougall IC, et al. A controlled study of the effects of ferric carboxymaltose on bone and haematinic biomarkers in chronic kidney disease and pregnancy. Nephrol Dial Transplant [Internet]. 2018;33:1628-35. doi: https://doi.org/10.1093/ndt/ gfx310
dc.relation.urihttps://revistas.unab.edu.co/index.php/medunab/issue/view/284spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.sourceVol. 25 Núm. 2 (2022): agosto - noviembre 2022: Bioética, Anomalías Congénitas, Práctica Psicológica; 279-289spa
dc.subjectAnemiaspa
dc.subjectDeficiencias de Hierrospa
dc.subjectComplicaciones del Embarazospa
dc.subjectFenómenos Fisiológicos Nutricionales Maternosspa
dc.subjectCompuestos de Hierrospa
dc.subjectFarmacocinéticaspa
dc.subject.keywordsMedical scienceseng
dc.subject.keywordsLife scienceseng
dc.subject.keywordsAnemiaeng
dc.subject.keywordsIron Deficiencieseng
dc.subject.keywordsPregnancy Complicationseng
dc.subject.keywordsMaternal Nutritional Physiological Phenomenaeng
dc.subject.keywordsIron Compoundseng
dc.subject.keywordsPharmacokineticseng
dc.subject.keywordsHealth scienceseng
dc.subject.keywordsCiências médicaspor
dc.subject.keywordsCiências da vidapor
dc.subject.keywordsCiências da saúdepor
dc.subject.keywordsAnemiapor
dc.subject.keywordsDeficiências de Ferropor
dc.subject.keywordsComplicações na Gravidezpor
dc.subject.keywordsFenômenos Fisiológicos da Nutrição Maternapor
dc.subject.keywordsCompostos de Ferropor
dc.subject.keywordsFarmacocinéticapor
dc.subject.lembCiencias médicasspa
dc.subject.lembCiencias de la vidaspa
dc.subject.lembCiencias de la saludspa
dc.titleBeneficios del uso del hierro parenteral como alternativa eficaz en el manejo de la anemia gestacional en Colombiaspa
dc.title.translatedBenefits of the Use of Parenteral Iron as an Efficient Alternative in the Management of Gestational Anemia in Colombiaeng
dc.title.translatedBenefícios do uso de ferro parenteral como alternativa eficaz no manejo da anemia gestacional na Colômbiapor
dc.typeArticleeng
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículospa
dc.type.redcolhttp://purl.org/redcol/resource_type/ART

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