Patrones inmunopatológicos de la tuberculosis en pacientes con compromiso de la respuesta inmune celular
| dc.contributor.author | Pérez Carrillo, José Arnulfo | spa |
| dc.contributor.cvlac | Pérez Carrillo, José Arnulfo [0001128493] | spa |
| dc.contributor.googlescholar | Pérez Carrillo, José Arnulfo [m0Hvm0EAAAAJ&hl=es&oi=ao] | spa |
| dc.contributor.orcid | Pérez Carrillo, José Arnulfo [0000-0003-0636-4959] | spa |
| dc.date.accessioned | 2020-10-27T14:21:20Z | |
| dc.date.available | 2020-10-27T14:21:20Z | |
| dc.date.issued | 2006-12-04 | |
| dc.description.abstract | La tuberculosis es una enfermedad incidente a nivel mundial especialmente en países en vías de desarrollo. Con el advenimiento del Virus de Inmunodeficiencia Humana y el uso de agentes inhibidores del Factor de Necrosis Tumoral (FNT) α, han cambiado las presentaciones clínicas de la tuberculosis. Esto debido a una alteración en el equilibrio de la respuesta inmune adquirida ejecutada principalmente por las formas maduras de macrófagos activados coordinados por los Linfocitos T αβ CD4+ a través del FNTα y del Interferón (IFN) γ, presentándose histológicamente en forma de granuloma. Por tal razón, se han venido observando formas histopatológicas inusuales del granuloma, que se expresan en formas diseminadas en pacientes que finalmente fallecen. Este artículo presenta una revisión de los aspectos inmunológicos de estos granulomas y su repercusión clínica. [Pérez JA. Patrones inmunopatológicos de la tuberculosis en pacientes con compromiso de la respuesta inmune celular. | spa |
| dc.description.abstractenglish | Tuberculosis is an illness worldwide especially in developing coun-tries. The outbreak of the Human Immunodeficiency Virus and the use of inhibiting agents of Tumoral Necrosis Factor-α (TNFα) have resulted in changed clinical manifestations of Tuberculosis. This is due to altered balance in acquired immune response conducted mainly by lymphocyte-Tαβ CD4+-coordinated actived mature forms of macrophages through TNFα and Interferon-γ with histological presentation in the form of granuloma. For such reason, incidence of hystopathologically unusual forms of granuloma has been observed as of lately expressed in disseminated forms in patients who even-tually pass away. This article reviews the immunologicals aspects of these granulomas and their clinical repercussions. [Pérez JA. Immunophatological patterns in TB patients with damaged cellular response | eng |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.instname | instname:Universidad Autónoma de Bucaramanga UNAB | spa |
| dc.identifier.issn | 2382-4603 | |
| dc.identifier.issn | 0123-7047 | |
| dc.identifier.repourl | repourl:https://repository.unab.edu.co | |
| dc.identifier.uri | http://hdl.handle.net/20.500.12749/10371 | |
| dc.language.iso | spa | spa |
| dc.publisher | Universidad Autónoma de Bucaramanga UNAB | |
| dc.publisher.faculty | Facultad Ciencias de la Salud | spa |
| dc.publisher.program | Pregrado Medicina | spa |
| dc.relation | https://revistas.unab.edu.co/index.php/medunab/article/view/138/123 | |
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| dc.relation.references | Frieden TR, Sterling TR, Munsiff SS, et al. Tuberculosis. Lancet 2003; 362: 887-99 | spa |
| dc.relation.references | Gardam MA, Keystone EC, Menzies R, et al. Antitumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management. Lancet Infect Dis 2003; 3: 148-55 | spa |
| dc.relation.references | World Health Organization [WHO]. Fact Sheet 104: Tuberculosis. Geneva: WHO, 2005. Available at: http://www.who.int/mediacen-tre/factsheets/who104/index.html. Revisado el 27 Noviembre 2005 | spa |
| dc.relation.references | Zahrt TC. Molecular Mechanisms regulating persistent Mycobac-terium tuberculosis infection. Microbes Infect 2003; 5:159-67 | spa |
| dc.relation.references | Raja A. Immunology of tuberculosis. Indian J Med Res 2004; 11: 213–32 | spa |
| dc.relation.references | Lawn SD, Butera ST, Shinnick TM. Tuberculosis unleashed: the impact of human inmunodeficiency virus infection on the host granulomatous response to Mycobacterium tuberculosis. Microbes Infect 2004; 4: 635– 46 | spa |
| dc.relation.references | Orme IM, Cooper AM. Cytokine/chemokine cascades in immu-nity to tuberculosis. Immunol Today 1999; 20: 307-12 | spa |
| dc.relation.references | Flynn JA, Ernst JD. Immune responses in tuberculosis. Curr Opin Immunol 2000; 12: 432-436 | spa |
| dc.relation.references | Boom WH, Canaday DH, Fulton SA, Gehring AJ, Rojas RE, Torres M. Human immunity to M. tuberculosis: T cell Subsets and antigen processing. Tuberculosis 2003; 83: 98–106 | spa |
| dc.relation.uri | https://revistas.unab.edu.co/index.php/medunab/article/view/138 | |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.creativecommons | Atribución-NoComercial-SinDerivadas 2.5 Colombia | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | |
| dc.source | MedUNAB; Vol. 9 Núm. 3 (2006): Modulación PPARγ, Crisis Psicogénica, Rendimiento y estrés; 221-229 | |
| dc.subject | Ciencias biomédicas | |
| dc.subject | Ciencias de la vida | |
| dc.subject | Innovaciones en salud | |
| dc.subject | Investigaciones | |
| dc.subject.keywords | Health Sciences | eng |
| dc.subject.keywords | Medicine | eng |
| dc.subject.keywords | Medical Sciences | eng |
| dc.subject.keywords | Biomedical Sciences | eng |
| dc.subject.keywords | Life Sciences | eng |
| dc.subject.keywords | Innovations in health | eng |
| dc.subject.keywords | Research | eng |
| dc.subject.keywords | Tuberculosis | eng |
| dc.subject.keywords | Immunology | eng |
| dc.subject.keywords | Granuloma | eng |
| dc.subject.keywords | Human immunodefienciency virus | eng |
| dc.subject.keywords | Tumour necrosis factor-α | eng |
| dc.subject.lemb | Medicina | spa |
| dc.subject.lemb | Ciencias de la salud | spa |
| dc.subject.lemb | Ciencias médicas | spa |
| dc.subject.proposal | Tuberculosis | spa |
| dc.subject.proposal | Inmunología | spa |
| dc.subject.proposal | Granuloma | spa |
| dc.subject.proposal | Virus de inmunodeficiencia humana | spa |
| dc.subject.proposal | Factor de necrosis tumoral | spa |
| dc.title | Patrones inmunopatológicos de la tuberculosis en pacientes con compromiso de la respuesta inmune celular | spa |
| dc.title.translated | Immunopathological patterns of tuberculosis in patients with compromised cellular immune response | eng |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | |
| dc.type.driver | info:eu-repo/semantics/article | |
| dc.type.hasversion | Info:eu-repo/semantics/publishedVersion | |
| dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
| dc.type.local | Artículo | spa |
| dc.type.redcol | http://purl.org/redcol/resource_type/ART |
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