Relación entre la fragilidad y la polifarmacia en el deterioro cognitivo de los adultos mayores chilenos
| dc.contributor.author | Arauna, Diego | |
| dc.contributor.author | Navarrete, Simón | |
| dc.contributor.author | Molina, Nacim | |
| dc.contributor.author | Reyes, Lemuel | |
| dc.contributor.author | Rojas, Juan Pablo | |
| dc.contributor.author | Fuentes, Eduardo | |
| dc.contributor.author | Palomo, Iván | |
| dc.contributor.orcid | Arauna, Diego [0000-0001-7132-991X] | spa |
| dc.contributor.orcid | Navarrete, Simón [0000-0001-5296-1215] | spa |
| dc.contributor.orcid | Molina, Nacim [0000-0001-7902-6905] | spa |
| dc.contributor.orcid | Reyes, Lemuel [0009-0008-9459-2831] | spa |
| dc.contributor.orcid | Rojas, Juan Pablo [0000-0001-7688-9166] | spa |
| dc.contributor.orcid | Fuentes, Eduardo [0000-0003-0099-4108] | spa |
| dc.contributor.orcid | Palomo, Iván [0000-0002-9618-8778] | spa |
| dc.date.accessioned | 2026-01-28T21:26:33Z | |
| dc.date.available | 2026-01-28T21:26:33Z | |
| dc.date.issued | 2025-09-01 | |
| dc.description.abstract | El envejecimiento acelerado de la población aumenta el riesgo de aparición de complicaciones geriátricas, como el deterioro cognitivo. Este deterioro se ha relacionado con el síndrome de fragilidad y la polifarmacia en cohortes europeas; sin embargo, su relación no se ha aclarado completamente en las personas mayores latinoamericanas. El objetivo de este estudio fue evaluar la relación entre el deterioro cognitivo, la polifarmacia y el síndrome de fragilidad en adultos mayores chilenos | spa |
| dc.description.abstractenglish | The accelerated aging of the population increases the risk of the appearance of geriatric complications, such as cognitive damage. This damage has been related to frailty syndrome and polypharmacy in European cohorts, however, its relationship has not been fully clarified in Latin-American older people. This study aimed to evaluate the relationship between cognitive impairment, polypharmacy, and the frailty syndrome in Chilean older adults. | eng |
| dc.description.abstractother | O envelhecimento acelerado da população aumenta o risco de complicações geriátricas, como o declínio cognitivo. Esse declínio tem sido associado à síndrome de fragilidade e à polifarmácia em grupos europeus; no entanto, sua relação ainda não foi totalmente esclarecida em idosos latino-americanos. O objetivo deste estudo foi avaliar a relação entre o declínio cognitivo, a polifarmácia e a síndrome de fragilidade em idosos chilenos. | por |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.doi | https://doi.org/10.29375/01237047.5107 | |
| dc.identifier.instname | instname:Universidad Autónoma de Bucaramanga UNAB | spa |
| dc.identifier.issn | i-ISSN 0123-7047 | spa |
| dc.identifier.issn | e-ISSN 2382-4603 | spa |
| dc.identifier.reponame | reponame:Repositorio Institucional UNAB | spa |
| dc.identifier.repourl | repourl:https://repository.unab.edu.co | spa |
| dc.identifier.uri | http://hdl.handle.net/20.500.12749/32675 | |
| dc.language.iso | spa | spa |
| dc.publisher.faculty | Facultad Ciencias de la Salud | spa |
| dc.publisher.grantor | Universidad Autónoma de Bucaramanga UNAB | spa |
| dc.relation | https://revistas.unab.edu.co/index.php/medunab/article/view/5107/4247 | spa |
| dc.relation.references | World Health Organization. Informe Mundial sobre el envejecimiento y la salud [Internet]. Ginebra: WHO; 2015. Available from: https://www.who.int/es/ publications/i/item/9789241565042 | |
| dc.relation.references | Ministerio de Desarrollo Social. Informe de Desarrollo Social [Internet]. Chile: Ministerio de Desarrollo Social; 2017. Available from: https://www. desarrollosocialyfamilia.gob.cl/pdf/upload/IDS2017.pdf | |
| dc.relation.references | Instituto Nacional de Estadísticas. Chile: estimaciones y proyecciones de población por sexo, edad, total país: 1950-2050 [Internet]. Chile: INE-CEPAL; 1995. Available from: https://repositorio.cepal.org/entities/ publication/8e5d0343-636e-4a81-b59f-ec0d8511dcfb | |
| dc.relation.references | He W, Goodkind D, Kowal P. An Aging World: 2015. International Population Reports [Internet]. United States: United States Boreau; 2016. Available from: https://www.census.gov/content/dam/Census/library/ publications/2016/demo/p95-16-1.pdf | |
| dc.relation.references | Bektas A, Schurman SH, Sen R, Ferrucci L. Aging, inflammation and the environment. Exp Gerontol [Internet]. 2018;105:10-18. doi: https://doi.org/10.1016/j. exger.2017.12.015 | |
| dc.relation.references | Bademli K, Lok N, Canbaz M, Lok S. Effects of Physical Activity Program on cognitive function and sleep quality in elderly with mild cognitive impairment: A randomized controlled trial. Perspect Psychiatr care [Internet]. 2019;55(3):401-408. doi: https://doi.org/10.1111/ ppc.12324 | |
| dc.relation.references | Chudiak A, Uchmanowicz I, Mazur G. Relation between cognitive impairment and treatment adherence in elderly hypertensive patients. Clin Interv Aging [Internet]. 2018;13:1409-18. doi: https://doi.org/10.2147/CIA. S162701 | |
| dc.relation.references | Degl’Innocenti A, Elmfeldt D, Hansson L, Breteler M, James O, Lithell H, et al. Cognitive function and health-related quality of life in elderly patients with hypertension--baseline data from the study on cognition and prognosis in the elderly (SCOPE). Blood pressure [Internet]. 2002;11(3):157-65. doi: https://doi. org/10.1080/080370502760050395 | |
| dc.relation.references | Christensen H, Jorm AF, Henderson AS, Mackinnon AJ, Korten AE, Scott LR. The relationship between health and cognitive functioning in a sample of elderly people in the community. Age Ageing [Internet]. 1994;23(3):204- 12. doi: https://doi.org/10.1093/ageing/23.3.204 | |
| dc.relation.references | Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review) [Retired]. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology [Internet]. 2001;56(9):1133-42. doi: https://doi.org/10.1212/wnl.56.9.1133 | |
| dc.relation.references | Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, et al. Mild cognitive impairment. Lancet [Internet]. 2006;367(9518):1262-70. doi: https://doi. org/10.1016/s0140-6736(06)68542-5 | |
| dc.relation.references | Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res [Internet]. 1975;12(3):189-98. doi: https://doi.org/10.1016/0022- 3956(75)90026-6 | |
| dc.relation.references | Muñoz-Silva CA, Rojas-Orellana PA, Marzuca- Nassr GN. Criterios de valoración geriátrica integral en adultos mayores con dependencia moderada y severa en Centros de Atención Primaria en Chile. Rev méd Chile [Internet]. 2015;143(5):612-8. Available from: https://www.scielo.cl/scielo.php?script=sci_ arttext&pid=S0034-98872015000500009 | |
| dc.relation.references | Shim YS, Yang DW, Kim H-J, Park YH, Kim S. Characteristic differences in the mini-mental state examination used in Asian countries. BMC Neurol [Internet]. 2017;17(1):141. doi: https://doi.org/10.1186/ s12883-017-0925-z | |
| dc.relation.references | Arevalo-Rodriguez I, Smailagic N, Roqué-Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A, et al. Mini- Mental State Examination (MMSE) for the detection of Alzheimer’s disease and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev [Internet]. 2015;2015(3):CD010783. doi: https://doi.org/10.1002/14651858.cd010783.pub2 | |
| dc.relation.references | Pais R, Ruano L, Carvalho OP, Barros H. Global Cognitive Impairment Prevalence and Incidence in Community Dwelling Older Adults-A Systematic Review. Geriatrics (Basel) [Internet]. 2020;5(4):84. doi: https://doi.org/10.3390/geriatrics5040084 | |
| dc.relation.references | Vega-Alonso T, Miralles-Espí M, Mangas-Reina JM, Castrillejo-Pérez D, Rivas-Pérez AI, Gil-Costa M, et al. Prevalence of cognitive impairment in Spain: The Gómez de Caso study in health sentinel networks. Neurologia (Engl Ed) [Internet]. 2018;33(8):491-8. doi: https://doi. org/10.1016/j.nrl.2016.10.002 | |
| dc.relation.references | Albala C, Lera L, Sanchez H, Angel B, Marquez C, Arroyo P, et al. Frequency of frailty and its association with cognitive status and survival in older Chileans. Clin Interv Aging [Internet]. 2017;12:995-1001. doi: https:// doi.org/10.2147/cia.s136906 | |
| dc.relation.references | Prince MJ, Wu F, Guo Y, Gutierrez-Robledo LM, O’Donnell M, Sullivan R, et al. The burden of disease in older people and implications for health policy and practice. Lancet [Internet]. 2015;385(9967):549-62. doi: https://doi.org/10.1016/s0140-6736(14)61347-7 | |
| dc.relation.references | Barberger-Gateau P, Fabrigoule C. Disability and cognitive impairment in the elderly. Disabil Rehabil [Internet]. 1997;19(5):175-93. doi: https://doi. org/10.3109/09638289709166525 | |
| dc.relation.references | Moon JH, Huh JS, Won CW, Kim HJ. Is Polypharmacy Associated with Cognitive Frailty in the Elderly? Results from the Korean Frailty and Aging Cohort Study. The journal of nutrition, health & aging. 2019;23(10):958-65. Moon JH, Huh JS, Won CW, Kim HJ. Is Polypharmacy Associated with Cognitive Frailty in the Elderly? Results from the Korean Frailty and Aging Cohort Study. J Nutr Health Aging [Internet]. 2019;23(10):958-65. doi: https:// doi.org/10.1007/s12603-019-1274-y | |
| dc.relation.references | Gobbens RJ, Schols JM, van Assen MA. Exploring the efficiency of the Tilburg Frailty Indicator: a review. Clin Interv Aging [Internet]. 2017;12:1739-52. doi: https:// doi.org/10.2147/cia.s130686 | |
| dc.relation.references | Alonso-Bouzon C, Carcaillon L, Garcia-Garcia FJ, Amor- Andres MS, Assar ME, Rodriguez-Mañas L. Association between endothelial dysfunction and frailty: the Toledo Study for Healthy Aging. Age (Dordr) [Internet]. 2014;36(1):495-505. doi: https://doi.org/10.1007/ s11357-013-9576-1 | |
| dc.relation.references | Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci [Internet]. 2001;56(3):M146-56. doi: https://doi.org/10.1093/ gerona/56.3.m146 | |
| dc.relation.references | Sardella A, Catalano A, Lenzo V, Bellone F, Corica F, Quattropani MC, et al. Association between cognitive reserve dimensions and frailty among older adults: A structured narrative review. Geriatr Gerontol Int [Internet]. 2020;20(11):1005-23. doi: https://doi. org/10.1111/ggi.14040 | |
| dc.relation.references | Sargent L, Nalls M, Amella EJ, Slattum PW, Mueller M, Bandinelli S, et al. Shared mechanisms for cognitive impairment and physical frailty: A model for complex systems. Alzheimers Dement (N Y) [Internet]. 2020;6(1):e12027. doi: https://doi.org/10.1002/ trc2.12027 | |
| dc.relation.references | Borges MK, Canevelli M, Cesari M, Aprahamian I. Frailty as a Predictor of Cognitive Disorders: A Systematic Review and Meta-Analysis. Front Med (Lausanne) [Internet]. 2019;6:26. doi: https://doi.org/10.3389/ fmed.2019.00026 | |
| dc.relation.references | Robertson DA, Savva GM, Kenny RA. Frailty and cognitive impairment - A review of the evidence and causal mechanisms. Ageing Res Rev [Internet]. 2013;12(4):840- 51. doi: https://doi.org/10.1016/j.arr.2013.06.004 | |
| dc.relation.references | Inglés M, Mas-Bargues C, Gimeno-Mallench L, Cruz- Guerrero R, García-García FJ, Gambini J, et al. Relation Between Genetic Factors and Frailty in Older Adults. J Am Med Dir Assoc [Internet]. 2019;20(11):1451-7. doi: https://doi.org/10.1016/j.jamda.2019.03.011 | |
| dc.relation.references | Pansarasa O, Pistono C, Davin A, Bordoni M, Mimmi MC, Guaita A, et al. Altered immune system in frailty: Genetics and diet may influence inflammation. Ageing Res Rev [Internet]. 2019;54:100935. doi: https://doi. org/10.1016/j.arr.2019.100935 | |
| dc.relation.references | Palmer K, Villani ER, Vetrano DL, Cherubini A, Cruz- Jentoft AJ, Curtin D, et al. Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis. Eur Geriatr Med [Internet]. 2019;10(1):9-36. doi: https://doi.org/10.1007/s41999- 018-0124-5 | |
| dc.relation.references | Vetrano DL, Villani ER, Grande G, Giovannini S, Cipriani MC, Manes-Gravina E, et al. Association of Polypharmacy With 1-Year Trajectories of Cognitive and Physical Function in Nursing Home Residents: Results From a Multicenter European Study. J Am Med Dir Assoc [Internet]. 2018;19(8):710-713. doi: https:// doi.org/10.1016/j.jamda.2018.04.008 | |
| dc.relation.references | Umegaki H, Yanagawa M, Komiya H, Matsubara M, Fujisawa C, Suzuki Y, et al. Polypharmacy and gait speed in individuals with mild cognitive impairment. Geriatr Gerontol Int [Internet]. 2019;19(8):730-5. doi: https://doi.org/10.1111/ggi.13688 | |
| dc.relation.references | Rosted E, Schultz M, Sanders S. Frailty and polypharmacy in elderly patients are associated with a high readmission risk. Dan Med J [Internet]. 2016;63(9):A5274. Available from: https://pubmed. ncbi.nlm.nih.gov/27585531/ | |
| dc.relation.references | Bonaga B, Sanchez-Jurado PM, Martinez-Reig M, Ariza G, Rodriguez-Manas L, Gnjidic D, et al. Frailty, Polypharmacy, and Health Outcomes in Older Adults: The Frailty and Dependence in Albacete Study. J Am Med Dir Assoc [Internet]. 2018;19(1):46-52. doi: https://doi.org/10.1016/j.jamda.2017.07.008 | |
| dc.relation.references | Herr M, Robine JM, Pinot J, Arvieu JJ, Ankri J. Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people. Pharmacoepidemiol Drug Saf [Internet]. 2015;24(6):637- 46. doi: https://doi.org/10.1002/pds.3772 | |
| dc.relation.references | Palomo I, Giacaman RA, León S, Lobos G, Bustamante M, Wehinger S, et al. Analysis of the characteristics and components for the frailty syndrome in older adults from central Chile. The PIEI-ES study. Arch Gerontol Geriatr [Internet]. 2019;80:70-5. doi: https://doi.org/10.1016/j. archger.2018.10.004 | |
| dc.relation.references | Albala-Brevis C, Icaza G, Vio F, García C, Marín PP, Quiroga P. A short test to evaluate cognitive impairment based on Folstein’s MMSE. Gerontology. 2001;47(S1):S183. | |
| dc.relation.references | Ministerio de Salud. Manual de Aplicación del Examen de Medicina Preventiva del Adulto Mayor. División de Prevención y Control de Enfermedades. Subsecretaría de Salud Pública [Internet]. Chile: Minsal; 2010. Available from: https://diprece.minsal.cl/wrdprss_ minsal/wp-content/uploads/2015/05/instructivo-decontrol- de-salud-empam.pdf | |
| dc.relation.references | Noh B, Youm C, Lee M, Park H. Associating Gait Phase and Physical Fitness with Global Cognitive Function in the Aged. Int J Environ Res Public Health [Internet]. 2020;17(13):4786. doi: https://doi.org/10.3390/ ijerph17134786 | |
| dc.relation.references | Lera L, Albala C, Leyton B, Marquez C, Angel B, Saguez R, et al. Reference values of hand-grip dynamometry and the relationship between low strength and mortality in older Chileans. Clin Interv Aging [Internet]. 2018;13:317-24. doi: https://doi.org/10.2147/ cia.s152946 | |
| dc.relation.references | Garcia-Garcia FJ, Gutierrez-Avila G, Alfaro-Acha A, Amor-Andres MS, De La Torre-Lanza MA, Escribano- Aparicio MV, et al. The prevalence of frailty syndrome in an older population from Spain. The Toledo Study for Healthy Aging. J Nutr Health Aging [Internet]. 2011;15(10):852-6. Doi: https://doi.org/10.1007/ s12603-011-0075-8 | |
| dc.relation.references | Arauna D, Cerda A, García-García JF, Wehinger S, Castro F, Méndez D, et al. Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study. Clin Interv Aging [Internet]. 2020;15:1013-22. doi: https://doi.org/10.2147/cia.s247444 | |
| dc.relation.references | Gnjidic D, Hilmer SN, Blyth FM, Naganathan V, Waite L, Seibel MJ, et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify communitydwelling older men at risk of different adverse outcomes. J Clin Epidemiol [Internet]. 2012;65(9):989-95. doi: https://doi.org/10.1016/j.jclinepi.2012.02.018 | |
| dc.relation.references | Bartolini L. Deterioro cognitivo. Diagnosis [Internet]. 2019;16:27-35. Available from: https://dialnet.unirioja. es/servlet/articulo?codigo=7221180 | |
| dc.relation.references | Ortiz GG, Arias-Merino ED, Flores-Saiffe ME, Velazquez-Brizuela IE, Macias-Islas MA, Pacheco- Moises FP. Prevalence of Cognitive Impairment and Depression among a Population Aged over 60 Years in the Metropolitan Area of Guadalajara, Mexico. Curr Gerontol Geriatr Res [Internet]. 2012;2012:175019. doi: https://doi.org/10.1155/2012/175019 | |
| dc.relation.references | Saw YM, Saw TN, Than TM, Khaing M, Soe PP, Oo S, et al. Cognitive impairment and its risk factors among Myanmar elderly using the Revised Hasegawa’s Dementia Scale: A cross-sectional study in Nay Pyi Taw, Myanmar. PLoS One [Internet]. 2020;15(7):e0236656. doi: https://doi.org/10.1371/ journal.pone.0236656 | |
| dc.relation.references | Tombaugh TN, McIntyre NJ. The mini-mental state examination: a comprehensive review. J Am Geriatr Soc [Internet]. 1992;40(9):922-35. doi: https://doi. org/10.1111/j.1532-5415.1992.tb01992.x | |
| dc.relation.references | Li A, Chen S, Liu J, Chen T, Shi Y. CSL-CTEA: a systematic method for evaluating novel intelligent cognitive assessment tools. Health Inf Sci Syst [Internet]. 2025;13(1):29. doi: https://doi.org/10.1007/ s13755-025-00346-6 | |
| dc.relation.references | Ashby-Mitchell K, Jagger C, Fouweather T, Anstey KJ. Life expectancy with and without cognitive impairment in seven Latin American and Caribbean countries. PLoS One [Internet]. 2015;10(3):e0121867. doi: https://doi.org/10.1371/journal.pone.0121867 | |
| dc.relation.references | Makkar SR, Lipnicki DM, Crawford JD, Kochan NA, Castro-Costa E, Lima-Costa MF, et al. Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment. Arch Gerontol Geriatr [Internet]. 2020;91:104112. doi: https:// doi.org/10.1016/j.archger.2020.104112 | |
| dc.relation.references | Lee J, Ham MJ, Pyeon JY, Oh E, Jeong SH, Sohn EH, et al. Factors Affecting Cognitive Impairment and Depression in the Elderly Who Live Alone: Cases in Daejeon Metropolitan City. Dement Neurocogn Disord [Internet]. 2017;16(1):12-19. doi: https://doi. org/10.12779/dnd.2017.16.1.12 | |
| dc.relation.references | Jia J, Wang F, Wei C, Zhou A, Jia X, Li F, et al. The prevalence of dementia in urban and rural areas of China. Alzheimers Dement [Internet]. 2014;10(1):1-9. doi: https://doi.org/10.1016/j.jalz.2013.01.012 | |
| dc.relation.references | Wang J, Xiao LD, Wang K, Luo Y, Li X. Gender Differences in Cognitive Impairment among Rural Elderly in China. Int J Environ Res Public Health [Internet]. 2020;17(10). doi: https://doi.org/10.3390/ ijerph17103724 | |
| dc.relation.references | Robertson DA, Savva GM, Coen RF, Kenny RA. Cognitive function in the prefrailty and frailty syndrome. J Am Geriatr Soc [Internet]. 2014;62(11):2118-24. doi: https://doi.org/10.1111/jgs.13111 | |
| dc.relation.references | Alic A, Pranjic N, Ramic E. Polypharmacy and decreased cognitive abilities in elderly patients. Med Arh [Internet]. 2011;65(2):102-5. Available from: https://pubmed.ncbi. nlm.nih.gov/21585185/ | |
| dc.relation.references | Boyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA. Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc [Internet]. 2010;58(2):248-55. doi: https://doi.org/10.1111/j.1532-5415.2009.02671.x | |
| dc.relation.references | Chen S, Honda T, Narazaki K, Chen T, Kishimoto H, Haeuchi Y, et al. Physical Frailty Is Associated with Longitudinal Decline in Global Cognitive Function in Non-Demented Older Adults: A Prospective Study. J Nutr Health Aging [Internet]. 2018;22(1):82-8. doi. https://doi. org/10.1007/s12603-017-0924-1 | |
| dc.relation.references | Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology [Internet]. 2012;78(17):1323-9. doi: https://doi. org/10.1212/WNL.0b013e3182535d35 | |
| dc.relation.references | Yassuda MS, Lopes A, Cachioni M, Falcao DV, Batistoni SS, Guimaraes VV, et al. Frailty criteria and cognitive performance are related: data from the FIBRA study in Ermelino Matarazzo, Sao Paulo, Brazil. J Nutr Health Aging [Internet]. 2012;16(1):55-61. doi: https://doi. org/10.1007/s12603-012-0003-6 | |
| dc.relation.references | Buchman AS, Yu L, Wilson RS, Boyle PA, Schneider JA, Bennett DA. Brain pathology contributes to simultaneous change in physical frailty and cognition in old age. J Gerontol A Biol Sci Med Sci [Internet]. 2014;69(12):1536- 44. doi: https://doi.org/10.1093/gerona/glu117 | |
| dc.relation.references | Searle SD, Rockwood K. Frailty and the risk of cognitive impairment. Alzheimers Res Ther [Internet]. 2015;7(1):54. doi: https://doi.org/10.1186/s13195-015- 0140-3 | |
| dc.relation.references | Kizilarslanoğlu MC, Kara Ö, Yeşil Y, Kuyumcu ME, Öztürk ZA, Cankurtaran M, et al. Alzheimer disease, inflammation, and novel inflammatory marker: resistin. Turk J Med Sci [Internet]. 2015;45(5):1040-6. Available from: https://pubmed.ncbi.nlm.nih.gov/26738345 | |
| dc.relation.references | Buchman AS, Boyle PA, Wilson RS, Tang Y, Bennett DA. Frailty is associated with incident Alzheimer’s disease and cognitive decline in the elderly. Psychosom Med [Internet]. 2007;69(5):483-9. doi: https://doi. org/10.1097/psy.0b013e318068de1d | |
| dc.relation.references | Trevisan C, Limongi F, Siviero P, Noale M, Cignarella A, Manzato E, et al. Mild polypharmacy and MCI progression in older adults: the mediation effect of drugdrug interactions. Aging Clin Exp Res. 2021;33(1):49- 56. doi: https://doi.org/10.1007/s40520-019-01420-2 | |
| dc.relation.references | Morin L, Johnell K, Laroche ML, Fastbom J, Wastesson JW. The epidemiology of polypharmacy in older adults: register-based prospective cohort study. Clin Epidemiol [Internet]. 2018;10:289-98. doi: https://doi.org/10.2147/ clep.s153458 | |
| dc.relation.uri | https://revistas.unab.edu.co/index.php/medunab/issue/view/311 | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.creativecommons | Atribución-NoComercial-SinDerivadas 2.5 Colombia | * |
| dc.rights.local | Abierto (Texto Completo) | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | * |
| dc.source | Vol. 28 Núm. 2 (2025): agosto-noviembre 2025: Anciano; Cuidados Paliativos; Apoyo Social; 289-300 | spa |
| dc.subject | Ciencias médicas | spa |
| dc.subject | Ciencias de la vida | spa |
| dc.subject | Ciencias de la salud | spa |
| dc.subject | Fragilidad | spa |
| dc.subject | Polifarmacia | spa |
| dc.subject | Envejecimiento | spa |
| dc.subject | Anciano | spa |
| dc.subject | Envejecimiento cognitivo | spa |
| dc.subject | Pruebas de estado mental y demencia | spa |
| dc.subject | Estudios transversales | spa |
| dc.subject | Geriatría | spa |
| dc.subject.keywords | Medical sciences | eng |
| dc.subject.keywords | Life sciences | eng |
| dc.subject.keywords | Health sciences | eng |
| dc.subject.keywords | Ciências médicas | por |
| dc.subject.keywords | Ciências da vida | por |
| dc.subject.keywords | Ciências da saúde | por |
| dc.subject.keywords | Frailty | eng |
| dc.subject.keywords | Polypharmacy | eng |
| dc.subject.keywords | Aging | eng |
| dc.subject.keywords | Aged | eng |
| dc.subject.keywords | Cognitive aging | eng |
| dc.subject.keywords | Mental status and dementia tests | eng |
| dc.subject.keywords | Cross-sectional studies | eng |
| dc.subject.keywords | Geriatrics | eng |
| dc.subject.keywords | Fragilidade | por |
| dc.subject.keywords | Polimedicação | por |
| dc.subject.keywords | Envelhecimento | por |
| dc.subject.keywords | Idoso | por |
| dc.subject.keywords | Envelhecimento cognitivo | por |
| dc.subject.keywords | Testes de estado mental e demência | por |
| dc.subject.keywords | Estudos transversais | por |
| dc.subject.keywords | Geriatria | por |
| dc.subject.lemb | Ciencias médicas | spa |
| dc.subject.lemb | Ciencias de la vida | spa |
| dc.subject.proposal | Ciencias de la salud | spa |
| dc.title | Relación entre la fragilidad y la polifarmacia en el deterioro cognitivo de los adultos mayores chilenos | spa |
| dc.title.translated | Relation of frailty and polypharmacy on cognitive impairment in Chilean Older Adults | eng |
| dc.title.translated | Relação entre fragilidade e polifarmácia no declínio cognitivo de idosos chilenos | por |
| dc.type | Article | eng |
| dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa | spa |
| dc.type.driver | info:eu-repo/semantics/article | |
| dc.type.hasversion | info:eu-repo/semantics/publishedVersion | |
| dc.type.local | Artículo | spa |
| dc.type.redcol | http://purl.org/redcol/resource_type/ART |
Archivos
Bloque original
1 - 1 de 1
Cargando...
- Nombre:
- Artículo 2.pdf
- Tamaño:
- 799.95 KB
- Formato:
- Adobe Portable Document Format
- Descripción:
- Artículo
Bloque de licencias
1 - 1 de 1
Cargando...
- Nombre:
- license.txt
- Tamaño:
- 183 B
- Formato:
- Item-specific license agreed upon to submission
- Descripción:
