Relación entre la fragilidad y la polifarmacia en el deterioro cognitivo de los adultos mayores chilenos

dc.contributor.authorArauna, Diego
dc.contributor.authorNavarrete, Simón
dc.contributor.authorMolina, Nacim
dc.contributor.authorReyes, Lemuel
dc.contributor.authorRojas, Juan Pablo
dc.contributor.authorFuentes, Eduardo
dc.contributor.authorPalomo, Iván
dc.contributor.orcidArauna, Diego [0000-0001-7132-991X]spa
dc.contributor.orcidNavarrete, Simón [0000-0001-5296-1215]spa
dc.contributor.orcidMolina, Nacim [0000-0001-7902-6905]spa
dc.contributor.orcidReyes, Lemuel [0009-0008-9459-2831]spa
dc.contributor.orcidRojas, Juan Pablo [0000-0001-7688-9166]spa
dc.contributor.orcidFuentes, Eduardo [0000-0003-0099-4108]spa
dc.contributor.orcidPalomo, Iván [0000-0002-9618-8778]spa
dc.date.accessioned2026-01-28T21:26:33Z
dc.date.available2026-01-28T21:26:33Z
dc.date.issued2025-09-01
dc.description.abstractEl envejecimiento acelerado de la población aumenta el riesgo de aparición de complicaciones geriátricas, como el deterioro cognitivo. Este deterioro se ha relacionado con el síndrome de fragilidad y la polifarmacia en cohortes europeas; sin embargo, su relación no se ha aclarado completamente en las personas mayores latinoamericanas. El objetivo de este estudio fue evaluar la relación entre el deterioro cognitivo, la polifarmacia y el síndrome de fragilidad en adultos mayores chilenosspa
dc.description.abstractenglishThe accelerated aging of the population increases the risk of the appearance of geriatric complications, such as cognitive damage. This damage has been related to frailty syndrome and polypharmacy in European cohorts, however, its relationship has not been fully clarified in Latin-American older people. This study aimed to evaluate the relationship between cognitive impairment, polypharmacy, and the frailty syndrome in Chilean older adults.eng
dc.description.abstractotherO envelhecimento acelerado da população aumenta o risco de complicações geriátricas, como o declínio cognitivo. Esse declínio tem sido associado à síndrome de fragilidade e à polifarmácia em grupos europeus; no entanto, sua relação ainda não foi totalmente esclarecida em idosos latino-americanos. O objetivo deste estudo foi avaliar a relação entre o declínio cognitivo, a polifarmácia e a síndrome de fragilidade em idosos chilenos.por
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.29375/01237047.5107
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga UNABspa
dc.identifier.issni-ISSN 0123-7047spa
dc.identifier.issne-ISSN 2382-4603spa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/32675
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.relationhttps://revistas.unab.edu.co/index.php/medunab/article/view/5107/4247spa
dc.relation.referencesWorld Health Organization. Informe Mundial sobre el envejecimiento y la salud [Internet]. Ginebra: WHO; 2015. Available from: https://www.who.int/es/ publications/i/item/9789241565042
dc.relation.referencesMinisterio de Desarrollo Social. Informe de Desarrollo Social [Internet]. Chile: Ministerio de Desarrollo Social; 2017. Available from: https://www. desarrollosocialyfamilia.gob.cl/pdf/upload/IDS2017.pdf
dc.relation.referencesInstituto Nacional de Estadísticas. Chile: estimaciones y proyecciones de población por sexo, edad, total país: 1950-2050 [Internet]. Chile: INE-CEPAL; 1995. Available from: https://repositorio.cepal.org/entities/ publication/8e5d0343-636e-4a81-b59f-ec0d8511dcfb
dc.relation.referencesHe W, Goodkind D, Kowal P. An Aging World: 2015. International Population Reports [Internet]. United States: United States Boreau; 2016. Available from: https://www.census.gov/content/dam/Census/library/ publications/2016/demo/p95-16-1.pdf
dc.relation.referencesBektas A, Schurman SH, Sen R, Ferrucci L. Aging, inflammation and the environment. Exp Gerontol [Internet]. 2018;105:10-18. doi: https://doi.org/10.1016/j. exger.2017.12.015
dc.relation.referencesBademli K, Lok N, Canbaz M, Lok S. Effects of Physical Activity Program on cognitive function and sleep quality in elderly with mild cognitive impairment: A randomized controlled trial. Perspect Psychiatr care [Internet]. 2019;55(3):401-408. doi: https://doi.org/10.1111/ ppc.12324
dc.relation.referencesChudiak A, Uchmanowicz I, Mazur G. Relation between cognitive impairment and treatment adherence in elderly hypertensive patients. Clin Interv Aging [Internet]. 2018;13:1409-18. doi: https://doi.org/10.2147/CIA. S162701
dc.relation.referencesDegl’Innocenti A, Elmfeldt D, Hansson L, Breteler M, James O, Lithell H, et al. Cognitive function and health-related quality of life in elderly patients with hypertension--baseline data from the study on cognition and prognosis in the elderly (SCOPE). Blood pressure [Internet]. 2002;11(3):157-65. doi: https://doi. org/10.1080/080370502760050395
dc.relation.referencesChristensen H, Jorm AF, Henderson AS, Mackinnon AJ, Korten AE, Scott LR. The relationship between health and cognitive functioning in a sample of elderly people in the community. Age Ageing [Internet]. 1994;23(3):204- 12. doi: https://doi.org/10.1093/ageing/23.3.204
dc.relation.referencesPetersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review) [Retired]. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology [Internet]. 2001;56(9):1133-42. doi: https://doi.org/10.1212/wnl.56.9.1133
dc.relation.referencesGauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, et al. Mild cognitive impairment. Lancet [Internet]. 2006;367(9518):1262-70. doi: https://doi. org/10.1016/s0140-6736(06)68542-5
dc.relation.referencesFolstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res [Internet]. 1975;12(3):189-98. doi: https://doi.org/10.1016/0022- 3956(75)90026-6
dc.relation.referencesMuñoz-Silva CA, Rojas-Orellana PA, Marzuca- Nassr GN. Criterios de valoración geriátrica integral en adultos mayores con dependencia moderada y severa en Centros de Atención Primaria en Chile. Rev méd Chile [Internet]. 2015;143(5):612-8. Available from: https://www.scielo.cl/scielo.php?script=sci_ arttext&pid=S0034-98872015000500009
dc.relation.referencesShim YS, Yang DW, Kim H-J, Park YH, Kim S. Characteristic differences in the mini-mental state examination used in Asian countries. BMC Neurol [Internet]. 2017;17(1):141. doi: https://doi.org/10.1186/ s12883-017-0925-z
dc.relation.referencesArevalo-Rodriguez I, Smailagic N, Roqué-Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A, et al. Mini- Mental State Examination (MMSE) for the detection of Alzheimer’s disease and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev [Internet]. 2015;2015(3):CD010783. doi: https://doi.org/10.1002/14651858.cd010783.pub2
dc.relation.referencesPais R, Ruano L, Carvalho OP, Barros H. Global Cognitive Impairment Prevalence and Incidence in Community Dwelling Older Adults-A Systematic Review. Geriatrics (Basel) [Internet]. 2020;5(4):84. doi: https://doi.org/10.3390/geriatrics5040084
dc.relation.referencesVega-Alonso T, Miralles-Espí M, Mangas-Reina JM, Castrillejo-Pérez D, Rivas-Pérez AI, Gil-Costa M, et al. Prevalence of cognitive impairment in Spain: The Gómez de Caso study in health sentinel networks. Neurologia (Engl Ed) [Internet]. 2018;33(8):491-8. doi: https://doi. org/10.1016/j.nrl.2016.10.002
dc.relation.referencesAlbala C, Lera L, Sanchez H, Angel B, Marquez C, Arroyo P, et al. Frequency of frailty and its association with cognitive status and survival in older Chileans. Clin Interv Aging [Internet]. 2017;12:995-1001. doi: https:// doi.org/10.2147/cia.s136906
dc.relation.referencesPrince MJ, Wu F, Guo Y, Gutierrez-Robledo LM, O’Donnell M, Sullivan R, et al. The burden of disease in older people and implications for health policy and practice. Lancet [Internet]. 2015;385(9967):549-62. doi: https://doi.org/10.1016/s0140-6736(14)61347-7
dc.relation.referencesBarberger-Gateau P, Fabrigoule C. Disability and cognitive impairment in the elderly. Disabil Rehabil [Internet]. 1997;19(5):175-93. doi: https://doi. org/10.3109/09638289709166525
dc.relation.referencesMoon JH, Huh JS, Won CW, Kim HJ. Is Polypharmacy Associated with Cognitive Frailty in the Elderly? Results from the Korean Frailty and Aging Cohort Study. The journal of nutrition, health & aging. 2019;23(10):958-65. Moon JH, Huh JS, Won CW, Kim HJ. Is Polypharmacy Associated with Cognitive Frailty in the Elderly? Results from the Korean Frailty and Aging Cohort Study. J Nutr Health Aging [Internet]. 2019;23(10):958-65. doi: https:// doi.org/10.1007/s12603-019-1274-y
dc.relation.referencesGobbens RJ, Schols JM, van Assen MA. Exploring the efficiency of the Tilburg Frailty Indicator: a review. Clin Interv Aging [Internet]. 2017;12:1739-52. doi: https:// doi.org/10.2147/cia.s130686
dc.relation.referencesAlonso-Bouzon C, Carcaillon L, Garcia-Garcia FJ, Amor- Andres MS, Assar ME, Rodriguez-Mañas L. Association between endothelial dysfunction and frailty: the Toledo Study for Healthy Aging. Age (Dordr) [Internet]. 2014;36(1):495-505. doi: https://doi.org/10.1007/ s11357-013-9576-1
dc.relation.referencesFried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci [Internet]. 2001;56(3):M146-56. doi: https://doi.org/10.1093/ gerona/56.3.m146
dc.relation.referencesSardella A, Catalano A, Lenzo V, Bellone F, Corica F, Quattropani MC, et al. Association between cognitive reserve dimensions and frailty among older adults: A structured narrative review. Geriatr Gerontol Int [Internet]. 2020;20(11):1005-23. doi: https://doi. org/10.1111/ggi.14040
dc.relation.referencesSargent L, Nalls M, Amella EJ, Slattum PW, Mueller M, Bandinelli S, et al. Shared mechanisms for cognitive impairment and physical frailty: A model for complex systems. Alzheimers Dement (N Y) [Internet]. 2020;6(1):e12027. doi: https://doi.org/10.1002/ trc2.12027
dc.relation.referencesBorges MK, Canevelli M, Cesari M, Aprahamian I. Frailty as a Predictor of Cognitive Disorders: A Systematic Review and Meta-Analysis. Front Med (Lausanne) [Internet]. 2019;6:26. doi: https://doi.org/10.3389/ fmed.2019.00026
dc.relation.referencesRobertson DA, Savva GM, Kenny RA. Frailty and cognitive impairment - A review of the evidence and causal mechanisms. Ageing Res Rev [Internet]. 2013;12(4):840- 51. doi: https://doi.org/10.1016/j.arr.2013.06.004
dc.relation.referencesInglés M, Mas-Bargues C, Gimeno-Mallench L, Cruz- Guerrero R, García-García FJ, Gambini J, et al. Relation Between Genetic Factors and Frailty in Older Adults. J Am Med Dir Assoc [Internet]. 2019;20(11):1451-7. doi: https://doi.org/10.1016/j.jamda.2019.03.011
dc.relation.referencesPansarasa O, Pistono C, Davin A, Bordoni M, Mimmi MC, Guaita A, et al. Altered immune system in frailty: Genetics and diet may influence inflammation. Ageing Res Rev [Internet]. 2019;54:100935. doi: https://doi. org/10.1016/j.arr.2019.100935
dc.relation.referencesPalmer K, Villani ER, Vetrano DL, Cherubini A, Cruz- Jentoft AJ, Curtin D, et al. Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis. Eur Geriatr Med [Internet]. 2019;10(1):9-36. doi: https://doi.org/10.1007/s41999- 018-0124-5
dc.relation.referencesVetrano DL, Villani ER, Grande G, Giovannini S, Cipriani MC, Manes-Gravina E, et al. Association of Polypharmacy With 1-Year Trajectories of Cognitive and Physical Function in Nursing Home Residents: Results From a Multicenter European Study. J Am Med Dir Assoc [Internet]. 2018;19(8):710-713. doi: https:// doi.org/10.1016/j.jamda.2018.04.008
dc.relation.referencesUmegaki H, Yanagawa M, Komiya H, Matsubara M, Fujisawa C, Suzuki Y, et al. Polypharmacy and gait speed in individuals with mild cognitive impairment. Geriatr Gerontol Int [Internet]. 2019;19(8):730-5. doi: https://doi.org/10.1111/ggi.13688
dc.relation.referencesRosted E, Schultz M, Sanders S. Frailty and polypharmacy in elderly patients are associated with a high readmission risk. Dan Med J [Internet]. 2016;63(9):A5274. Available from: https://pubmed. ncbi.nlm.nih.gov/27585531/
dc.relation.referencesBonaga B, Sanchez-Jurado PM, Martinez-Reig M, Ariza G, Rodriguez-Manas L, Gnjidic D, et al. Frailty, Polypharmacy, and Health Outcomes in Older Adults: The Frailty and Dependence in Albacete Study. J Am Med Dir Assoc [Internet]. 2018;19(1):46-52. doi: https://doi.org/10.1016/j.jamda.2017.07.008
dc.relation.referencesHerr M, Robine JM, Pinot J, Arvieu JJ, Ankri J. Polypharmacy and frailty: prevalence, relationship, and impact on mortality in a French sample of 2350 old people. Pharmacoepidemiol Drug Saf [Internet]. 2015;24(6):637- 46. doi: https://doi.org/10.1002/pds.3772
dc.relation.referencesPalomo I, Giacaman RA, León S, Lobos G, Bustamante M, Wehinger S, et al. Analysis of the characteristics and components for the frailty syndrome in older adults from central Chile. The PIEI-ES study. Arch Gerontol Geriatr [Internet]. 2019;80:70-5. doi: https://doi.org/10.1016/j. archger.2018.10.004
dc.relation.referencesAlbala-Brevis C, Icaza G, Vio F, García C, Marín PP, Quiroga P. A short test to evaluate cognitive impairment based on Folstein’s MMSE. Gerontology. 2001;47(S1):S183.
dc.relation.referencesMinisterio de Salud. Manual de Aplicación del Examen de Medicina Preventiva del Adulto Mayor. División de Prevención y Control de Enfermedades. Subsecretaría de Salud Pública [Internet]. Chile: Minsal; 2010. Available from: https://diprece.minsal.cl/wrdprss_ minsal/wp-content/uploads/2015/05/instructivo-decontrol- de-salud-empam.pdf
dc.relation.referencesNoh B, Youm C, Lee M, Park H. Associating Gait Phase and Physical Fitness with Global Cognitive Function in the Aged. Int J Environ Res Public Health [Internet]. 2020;17(13):4786. doi: https://doi.org/10.3390/ ijerph17134786
dc.relation.referencesLera L, Albala C, Leyton B, Marquez C, Angel B, Saguez R, et al. Reference values of hand-grip dynamometry and the relationship between low strength and mortality in older Chileans. Clin Interv Aging [Internet]. 2018;13:317-24. doi: https://doi.org/10.2147/ cia.s152946
dc.relation.referencesGarcia-Garcia FJ, Gutierrez-Avila G, Alfaro-Acha A, Amor-Andres MS, De La Torre-Lanza MA, Escribano- Aparicio MV, et al. The prevalence of frailty syndrome in an older population from Spain. The Toledo Study for Healthy Aging. J Nutr Health Aging [Internet]. 2011;15(10):852-6. Doi: https://doi.org/10.1007/ s12603-011-0075-8
dc.relation.referencesArauna D, Cerda A, García-García JF, Wehinger S, Castro F, Méndez D, et al. Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study. Clin Interv Aging [Internet]. 2020;15:1013-22. doi: https://doi.org/10.2147/cia.s247444
dc.relation.referencesGnjidic D, Hilmer SN, Blyth FM, Naganathan V, Waite L, Seibel MJ, et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify communitydwelling older men at risk of different adverse outcomes. J Clin Epidemiol [Internet]. 2012;65(9):989-95. doi: https://doi.org/10.1016/j.jclinepi.2012.02.018
dc.relation.referencesBartolini L. Deterioro cognitivo. Diagnosis [Internet]. 2019;16:27-35. Available from: https://dialnet.unirioja. es/servlet/articulo?codigo=7221180
dc.relation.referencesOrtiz GG, Arias-Merino ED, Flores-Saiffe ME, Velazquez-Brizuela IE, Macias-Islas MA, Pacheco- Moises FP. Prevalence of Cognitive Impairment and Depression among a Population Aged over 60 Years in the Metropolitan Area of Guadalajara, Mexico. Curr Gerontol Geriatr Res [Internet]. 2012;2012:175019. doi: https://doi.org/10.1155/2012/175019
dc.relation.referencesSaw YM, Saw TN, Than TM, Khaing M, Soe PP, Oo S, et al. Cognitive impairment and its risk factors among Myanmar elderly using the Revised Hasegawa’s Dementia Scale: A cross-sectional study in Nay Pyi Taw, Myanmar. PLoS One [Internet]. 2020;15(7):e0236656. doi: https://doi.org/10.1371/ journal.pone.0236656
dc.relation.referencesTombaugh TN, McIntyre NJ. The mini-mental state examination: a comprehensive review. J Am Geriatr Soc [Internet]. 1992;40(9):922-35. doi: https://doi. org/10.1111/j.1532-5415.1992.tb01992.x
dc.relation.referencesLi A, Chen S, Liu J, Chen T, Shi Y. CSL-CTEA: a systematic method for evaluating novel intelligent cognitive assessment tools. Health Inf Sci Syst [Internet]. 2025;13(1):29. doi: https://doi.org/10.1007/ s13755-025-00346-6
dc.relation.referencesAshby-Mitchell K, Jagger C, Fouweather T, Anstey KJ. Life expectancy with and without cognitive impairment in seven Latin American and Caribbean countries. PLoS One [Internet]. 2015;10(3):e0121867. doi: https://doi.org/10.1371/journal.pone.0121867
dc.relation.referencesMakkar SR, Lipnicki DM, Crawford JD, Kochan NA, Castro-Costa E, Lima-Costa MF, et al. Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment. Arch Gerontol Geriatr [Internet]. 2020;91:104112. doi: https:// doi.org/10.1016/j.archger.2020.104112
dc.relation.referencesLee J, Ham MJ, Pyeon JY, Oh E, Jeong SH, Sohn EH, et al. Factors Affecting Cognitive Impairment and Depression in the Elderly Who Live Alone: Cases in Daejeon Metropolitan City. Dement Neurocogn Disord [Internet]. 2017;16(1):12-19. doi: https://doi. org/10.12779/dnd.2017.16.1.12
dc.relation.referencesJia J, Wang F, Wei C, Zhou A, Jia X, Li F, et al. The prevalence of dementia in urban and rural areas of China. Alzheimers Dement [Internet]. 2014;10(1):1-9. doi: https://doi.org/10.1016/j.jalz.2013.01.012
dc.relation.referencesWang J, Xiao LD, Wang K, Luo Y, Li X. Gender Differences in Cognitive Impairment among Rural Elderly in China. Int J Environ Res Public Health [Internet]. 2020;17(10). doi: https://doi.org/10.3390/ ijerph17103724
dc.relation.referencesRobertson DA, Savva GM, Coen RF, Kenny RA. Cognitive function in the prefrailty and frailty syndrome. J Am Geriatr Soc [Internet]. 2014;62(11):2118-24. doi: https://doi.org/10.1111/jgs.13111
dc.relation.referencesAlic A, Pranjic N, Ramic E. Polypharmacy and decreased cognitive abilities in elderly patients. Med Arh [Internet]. 2011;65(2):102-5. Available from: https://pubmed.ncbi. nlm.nih.gov/21585185/
dc.relation.referencesBoyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA. Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc [Internet]. 2010;58(2):248-55. doi: https://doi.org/10.1111/j.1532-5415.2009.02671.x
dc.relation.referencesChen S, Honda T, Narazaki K, Chen T, Kishimoto H, Haeuchi Y, et al. Physical Frailty Is Associated with Longitudinal Decline in Global Cognitive Function in Non-Demented Older Adults: A Prospective Study. J Nutr Health Aging [Internet]. 2018;22(1):82-8. doi. https://doi. org/10.1007/s12603-017-0924-1
dc.relation.referencesBuchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology [Internet]. 2012;78(17):1323-9. doi: https://doi. org/10.1212/WNL.0b013e3182535d35
dc.relation.referencesYassuda MS, Lopes A, Cachioni M, Falcao DV, Batistoni SS, Guimaraes VV, et al. Frailty criteria and cognitive performance are related: data from the FIBRA study in Ermelino Matarazzo, Sao Paulo, Brazil. J Nutr Health Aging [Internet]. 2012;16(1):55-61. doi: https://doi. org/10.1007/s12603-012-0003-6
dc.relation.referencesBuchman AS, Yu L, Wilson RS, Boyle PA, Schneider JA, Bennett DA. Brain pathology contributes to simultaneous change in physical frailty and cognition in old age. J Gerontol A Biol Sci Med Sci [Internet]. 2014;69(12):1536- 44. doi: https://doi.org/10.1093/gerona/glu117
dc.relation.referencesSearle SD, Rockwood K. Frailty and the risk of cognitive impairment. Alzheimers Res Ther [Internet]. 2015;7(1):54. doi: https://doi.org/10.1186/s13195-015- 0140-3
dc.relation.referencesKizilarslanoğlu MC, Kara Ö, Yeşil Y, Kuyumcu ME, Öztürk ZA, Cankurtaran M, et al. Alzheimer disease, inflammation, and novel inflammatory marker: resistin. Turk J Med Sci [Internet]. 2015;45(5):1040-6. Available from: https://pubmed.ncbi.nlm.nih.gov/26738345
dc.relation.referencesBuchman AS, Boyle PA, Wilson RS, Tang Y, Bennett DA. Frailty is associated with incident Alzheimer’s disease and cognitive decline in the elderly. Psychosom Med [Internet]. 2007;69(5):483-9. doi: https://doi. org/10.1097/psy.0b013e318068de1d
dc.relation.referencesTrevisan C, Limongi F, Siviero P, Noale M, Cignarella A, Manzato E, et al. Mild polypharmacy and MCI progression in older adults: the mediation effect of drugdrug interactions. Aging Clin Exp Res. 2021;33(1):49- 56. doi: https://doi.org/10.1007/s40520-019-01420-2
dc.relation.referencesMorin L, Johnell K, Laroche ML, Fastbom J, Wastesson JW. The epidemiology of polypharmacy in older adults: register-based prospective cohort study. Clin Epidemiol [Internet]. 2018;10:289-98. doi: https://doi.org/10.2147/ clep.s153458
dc.relation.urihttps://revistas.unab.edu.co/index.php/medunab/issue/view/311spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.sourceVol. 28 Núm. 2 (2025): agosto-noviembre 2025: Anciano; Cuidados Paliativos; Apoyo Social; 289-300spa
dc.subjectCiencias médicasspa
dc.subjectCiencias de la vidaspa
dc.subjectCiencias de la saludspa
dc.subjectFragilidadspa
dc.subjectPolifarmaciaspa
dc.subjectEnvejecimientospa
dc.subjectAncianospa
dc.subjectEnvejecimiento cognitivospa
dc.subjectPruebas de estado mental y demenciaspa
dc.subjectEstudios transversalesspa
dc.subjectGeriatríaspa
dc.subject.keywordsMedical scienceseng
dc.subject.keywordsLife scienceseng
dc.subject.keywordsHealth scienceseng
dc.subject.keywordsCiências médicaspor
dc.subject.keywordsCiências da vidapor
dc.subject.keywordsCiências da saúdepor
dc.subject.keywordsFrailtyeng
dc.subject.keywordsPolypharmacyeng
dc.subject.keywordsAgingeng
dc.subject.keywordsAgedeng
dc.subject.keywordsCognitive agingeng
dc.subject.keywordsMental status and dementia testseng
dc.subject.keywordsCross-sectional studieseng
dc.subject.keywordsGeriatricseng
dc.subject.keywordsFragilidadepor
dc.subject.keywordsPolimedicaçãopor
dc.subject.keywordsEnvelhecimentopor
dc.subject.keywordsIdosopor
dc.subject.keywordsEnvelhecimento cognitivopor
dc.subject.keywordsTestes de estado mental e demênciapor
dc.subject.keywordsEstudos transversaispor
dc.subject.keywordsGeriatriapor
dc.subject.lembCiencias médicasspa
dc.subject.lembCiencias de la vidaspa
dc.subject.proposalCiencias de la saludspa
dc.titleRelación entre la fragilidad y la polifarmacia en el deterioro cognitivo de los adultos mayores chilenosspa
dc.title.translatedRelation of frailty and polypharmacy on cognitive impairment in Chilean Older Adultseng
dc.title.translatedRelação entre fragilidade e polifarmácia no declínio cognitivo de idosos chilenospor
dc.typeArticleeng
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículospa
dc.type.redcolhttp://purl.org/redcol/resource_type/ART

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