Correlación del espesor epitelial central y paracentral con el estadio del queratocono

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dc.contributor.advisorTello Hernández, Alejandro
dc.contributor.advisorNiño, Camilo Andrés
dc.contributor.apolounabTello Hernández, Alejandro [alejandro-tello-hernández]spa
dc.contributor.authorGarcía Sánchez, Juan Daniel
dc.contributor.cvlacTello Hernández, Alejandro [0001009125]spa
dc.contributor.googlescholarTello Hernández, Alejandro [puxZHKYAAAAJ]spa
dc.contributor.orcidGarcía Sánchez, Juan Daniel (0000-0002-5240-4782)spa
dc.contributor.orcidTello Hernández, Alejandro [0000-0001-5081-0720]spa
dc.contributor.researchgateTello Hernández, Alejandro [Alejandro_Tello2]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialFloridablanca (Santander, Colombia)spa
dc.coverage.temporal2020 2024spa
dc.date.accessioned2026-01-13T21:50:08Z
dc.date.available2026-01-13T21:50:08Z
dc.date.issued2025-11-21
dc.degree.nameEspecialista en Oftalmologíaspa
dc.description.abstractEl queratocono es una enfermedad progresiva que se caracteriza por adelgazamiento y protrusión corneal, lo que induce astigmatismo irregular y lleva a pérdida visual. El epitelio corneal, por su capacidad de remodelación, puede reflejar cambios topográficos tempranos, convirtiéndose en un posible marcador para la estratificación de la enfermedad. Metodología Se realizó un estudio transversal analítico que incluyó 480 ojos los cuales se clasificaron según una versión modificada de la clasificación de Amsler – Krumeich que contemplo los ojos sanos como estadio 0. Se midió el espesor epitelial central (3 mm) y paracentral (3-6 mm) con el tomógrafo MS-39 y se evaluaron sus correlaciones con el estadio clínico mediante pruebas no paramétricas, incluyendo correlaciones de Spearman.spa
dc.description.abstractenglishIntroduction Keratoconus is a progressive disease characterized by corneal thinning and protrusion, which induces irregular astigmatism and leads to visual loss. Due to its remodeling capacity, the corneal epithelium may reflect early topographic changes, making it a potential marker for disease stratification. Methods An analytical cross-sectional study was conducted including 480 eyes, which were classified according to a modified version of the Amsler–Krumeich classification that considered healthy eyes as stage 0. Central (3 mm) and paracentral (3–6 mm) epithelial thickness were measured using the MS-39 tomographer, and their correlations with clinical stage were assessed using nonparametric tests, including Spearman correlations.spa
dc.description.degreelevelEspecializaciónspa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontentsResumen del proyecto: ........................................................................................................... 4 Introducción ...................................................................................................................... 4 Metodología ....................................................................................................................... 4 Resultados .......................................................................................................................... 4 Conclusiones ...................................................................................................................... 5 Palabras clave (Key words) .............................................................................................. 5 1. Introducción: .................................................................................................................. 6 2. Justificación: .................................................................................................................. 9 3. Planteamiento del Problema ........................................................................................ 13 4. Marco teórico: .............................................................................................................. 15 5. Estado del Arte: ............................................................................................................ 26 6. Pregunta e hipótesis de investigación: ........................................................................ 35 7. Objetivos........................................................................................................................ 36 7.1. Objetivo General .................................................................................................. 36 7.2. Objetivos específicos ............................................................................................ 36 8. Metodología .................................................................................................................. 37 8.1. Tipo de estudio ..................................................................................................... 37 8.2. Población ............................................................................................................... 37 8.3. Criterios de inclusión ........................................................................................... 37 8.4. Criterios de exclusión .......................................................................................... 37 8.5. Cálculo de tamaño de muestra............................................................................ 37 8.6. Muestreo ............................................................................................................... 38 8.7. Recolección de la información ............................................................................ 39 8.8. Variables ............................................................................................................... 39 8.9. Plan de análisis de datos ...................................................................................... 39 10. Resultados ................................................................................................................. 43 11. Discusión: ................................................................................................................. 63 12. Referencias bibliográficas ........................................................................................ 69 Anexos: ................................................................................................................................. 74 Cronograma de actividades ................................................................................................. 96 Presupuesto .......................................................................................................................... 97spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/32567
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programEspecialización en Oftalmologíaspa
dc.publisher.programidEOFT-1042
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dc.relation.uriapolohttps://apolo.unab.edu.co/en/persons/alejandro-tello-hern%C3%A1ndez/spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsHealth sciencesspa
dc.subject.keywordsOphthalmologyspa
dc.subject.keywordsKeratoconusspa
dc.subject.keywordsCorneal topographyspa
dc.subject.keywordsCorneal epitheliumspa
dc.subject.keywordsOptical coherence tomographyspa
dc.subject.keywordsVision disordersspa
dc.subject.keywordsEyes (Diseases)spa
dc.subject.keywordsMyopiaspa
dc.subject.keywordsAstigmatismspa
dc.subject.lembOftalmologíaspa
dc.subject.lembCiencias médicasspa
dc.subject.lembCórneaspa
dc.subject.lembTrastornos de la visiónspa
dc.subject.lembOjos (Enfermedades)spa
dc.subject.lembMiopíaspa
dc.subject.lembAstigmatismospa
dc.subject.proposalCiencias de la saludspa
dc.subject.proposalQueratoconospa
dc.subject.proposalEpitelio cornealspa
dc.subject.proposalTopografía cornealspa
dc.subject.proposalTomografía de coherencia ópticaspa
dc.titleCorrelación del espesor epitelial central y paracentral con el estadio del queratoconospa
dc.title.translatedCorrelation of Central and Paracentral Epithelial Thickness with Keratoconus Stagespa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.redcolhttp://purl.org/redcol/resource_type/TM

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