Efecto de la cirugía bariátrica sobre la resistencia a la insulina en pacientes sin diabetes mellitus a un año de seguimiento

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dc.contributor.advisorWandurraga Sanchez, Edwin Antonio
dc.contributor.advisorLópez Gómez, Luis Ernesto
dc.contributor.apolounabWandurraga Sánchez, Edwin Antonio [edwin-antonio-wandurraga-sánchez]spa
dc.contributor.apolounabLópez Gómez, Luis Ernesto [luis-ernesto-lópez-gómez]spa
dc.contributor.authorDíaz Posada, Néstor Andrés
dc.contributor.corporatenameAdriana Lucila Reyes Gonzálezspa
dc.contributor.cvlacDíaz Posada, Néstor Andrés [0001753828]spa
dc.contributor.cvlacWandurraga Sánchez, Edwin Antonio [0001475567]spa
dc.contributor.cvlacLópez Gómez, Luis Ernesto [0001785761]spa
dc.contributor.orcidDíaz Posada, Néstor Andrés [0000-0002-3729-0043]spa
dc.contributor.orcidWandurraga Sánchez, Edwin Antonio [0000-0002-0529-2343]spa
dc.contributor.orcidLópez Gómez, Luis Ernesto [0000-0002-3666-2159]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialFloridablanca (Santander, Colombia)spa
dc.coverage.temporal2016 - 2021spa
dc.date.accessioned2023-04-25T12:51:19Z
dc.date.available2023-04-25T12:51:19Z
dc.date.issued2023-04-24
dc.degree.nameEspecialista en Medicina Internaspa
dc.description.abstractIntroducción: La obesidad no es solo un problema estético, es una enfermedad que viene en aumento alcanzando una prevalencia en Colombia del 18% para el 2015 según la encuesta ENSIN, la cual incrementa el riesgo cardiovascular asociado a la resistencia a la insulina (RI) y componente proinflamatorio crónico asociado a la adiposidad. Se desea conocer el impacto de la cirugía bariátrica en la perdida de peso según la resistencia a la insulina medida por HOMA-IR en nuestra población. Metodología: Cohorte mediante análisis de base de datos secundarios-anonimizados, recolectados entre 2016-2021 en una institución de alta complejidad en la ciudad de Bucaramanga, Santander, Colombia que fueron llevados a Gastrectomía vertical (GV) o Bypass gástrico (BGYR) con seguimiento a un año. Resultados: Respecto a la obesidad se logró normalización del IMC en el 42% llevados a GV y 26% a BGYR. En cuanto al síndrome metabólico de 94 pacientes cumplían criterios IDF adaptados a nuestra población previo a la intervención quirúrgica 60% GV y 20% BGYR persistiendo en menos del 2% en cada grupo posterior a un año esta condición. La RI en el grupo de BGYR pasó del 79,7% al 11,3% y en GV pasó del 86,5% al 23%. Conclusiones: La cirugía bariátrica es una herramienta eficaz para disminuir la RI, siendo este efecto mayor en la BGYR. Adicionalmente se demostró remsión del síndrome metabólico en el 98% que tenían esta condición previa al procedimiento.spa
dc.description.abstractenglishIntroduction: Obesity is not only an aesthetic problem, it is a disease that is increasing reaching a prevalence in Colombia of 18% for 2015 according to the ENSIN survey, which increases the cardiovascular risk associated with insulin resistance (IR). and chronic proinflammatory component associated with adiposity. We want to know the impact of bariatric surgery on weight loss according to insulin resistance measured by HOMA-IR in our population. Methodology: Cohort through secondary-anonymized database analysis, collected between 2016-2021 in a high complexity institution in the city of Bucaramanga, Santander, Colombia who underwent vertical gastrectomy (VG) or gastric bypass (RYGB) with follow-up. To one year. Results: Regarding obesity, BMI normalization was achieved in 42% taken to GV and 26% to RYGB. Regarding the metabolic syndrome, 94 patients met IDF criteria adapted to our population prior to surgical intervention, 60% GV and 20% RYGB, persisting in less than 2% in each group after one year of this condition. The IR in the RYGB group went from 79.7% to 11.3% and in GV it went from 86.5% to 23%. Conclusions: Bariatric surgery is an effective tool to reduce IR, with this effect being greater in RYGB. Additionally, remission of metabolic syndrome was demonstrated in 98% who had this condition prior to the procedure.spa
dc.description.degreelevelEspecializaciónspa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontentsResumen 4 Justificación 6 Marco Teórico 8 Terapia Dietética: 15 Terapia Farmacológica: 15 Cirugía Bariátrica 17 Estado del Arte 25 Objetivos 27 Objetivo General 27 Objetivos Específicos 27 Metodología 27 Tipo de estudio 27 Población 27 Criterios de Inclusión 27 Criterios de Exclusión 27 Cálculo de tamaño de muestra 28 Muestreo 28 Recolección de la información 29 Variables 29 Plan de análisis de datos 30 Análisis univariado: 30 Análisis Bivariado: 30 Consideraciones éticas 30 Resultados 31 Caracterización clínica población total 32 Obesidad 33 Síndrome metabólico 33 Resistencia a la insulina 36 Discusión 38 Conclusiones 47 Referencias Bibliográficas 47 ANEXO 1 54spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.29375/tesis.19640
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/19640
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programEspecialización en Medicina Internaspa
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dc.relation.uriapolohttps://apolo.unab.edu.co/en/persons/edwin-antonio-wandurraga-s%C3%A1nchezspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsInternal medicinespa
dc.subject.keywordsMedicinespa
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsHealth sciencesspa
dc.subject.keywordsObesityspa
dc.subject.keywordsMetabolic syndromespa
dc.subject.keywordsWeightlossspa
dc.subject.keywordsInsulin resistancespa
dc.subject.keywordsBariatric surgeryspa
dc.subject.keywordsMetabolism disordersspa
dc.subject.keywordsSurgical operationsspa
dc.subject.keywordsStomachspa
dc.subject.lembMedicina internaspa
dc.subject.lembMedicinaspa
dc.subject.lembCiencias médicasspa
dc.subject.lembTrastornos del metabolismospa
dc.subject.lembOperaciones quirúrgicasspa
dc.subject.lembEstómagospa
dc.subject.proposalCiencias de la saludspa
dc.subject.proposalCirugía bariátricaspa
dc.subject.proposalResistencia a la insulinaspa
dc.subject.proposalPérdida de pesospa
dc.subject.proposalSíndrome metabólicospa
dc.subject.proposalObesidadspa
dc.titleEfecto de la cirugía bariátrica sobre la resistencia a la insulina en pacientes sin diabetes mellitus a un año de seguimientospa
dc.title.translatedEffect of bariatric surgery on insulin resistance in patients without diabetes mellitus at one year of follow-up.spa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TM

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