Acciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicas

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dc.contributor.authorPardo Palencia, Alberto
dc.contributor.authorDíaz Martínez, Luis Alfonso
dc.contributor.authorCasas Romero, Juan Pablo
dc.contributor.authorGarcía Rey, Rafael Eduardo
dc.contributor.authorCortés Yepes, Julián
dc.contributor.authorGuillermo Barrera, Juan
dc.contributor.authorParra Zuluaga, Gustavo Adolfo
dc.contributor.authorJaimes Carvajal, Kermes
dc.contributor.authorGarcía Martínez, Rose Mary
dc.contributor.authorChaudhuri, Gautham
dc.contributor.authorLópez Jaramillo, Patricio
dc.contributor.cvlacPardo Palencia, Alberto [0001338711]spa
dc.contributor.cvlacDíaz Martínez, Luis Alfonso [0000066621]spa
dc.contributor.cvlacCasas Romero, Juan Pablo [0000018562]spa
dc.contributor.cvlacGarcía Rey, Rafael Eduardo [0001337277]spa
dc.contributor.cvlacParra Zuluaga, Gustavo Adolfo [0000291064]spa
dc.contributor.cvlacLópez Jaramillo, Patricio [0000043290]spa
dc.contributor.googlescholarDíaz Martínez, Luis Alfonso [es&oi=ao]
dc.contributor.googlescholarLópez Jaramillo, Patricio [s&oi=ao]spa
dc.contributor.orcidPardo Palencia, Alberto [0000-0003-4011-4232]spa
dc.contributor.orcidDíaz Martínez, Luis Alfonso [0000-0002-4498-6639]spa
dc.contributor.orcidParra Zuluaga, Gustavo Adolfo [0000-0003-1296-0853]spa
dc.contributor.orcidLópez Jaramillo, Patricio [0000-0002-9122-8742]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialBucaramanga (Santander, Colombia)spa
dc.coverage.temporal2002spa
dc.date.accessioned2022-10-12T14:12:27Z
dc.date.available2022-10-12T14:12:27Z
dc.date.issued2002
dc.degree.nameEspecialistas en Radiología e Imágenes Diagnósticasspa
dc.description.abstractLa administración de estrógenos como terapia hormonal sustitutiva (THS) en mujeres menopáusicas mejora la función mental y el estado emocional, efectos que pueden ser dados por el acción favorable en la función endotelial que se manifiesta por aumento del flujo sanguíneo cerebral mediado por óxido nítrico (NO). Sin embargo, la inducción de la síntesis no se limita a las células endoteliales ya que otros tejidos también son estimulados, como el cerebro, así que la mejora observada con suplencia estrogénica de las funciones encefálicas superiores de la mujer menopáusica puede deberse a un doble efecto de la THS, uno por aumento del flujo sanguíneo y otro por incremento de No en el propio sistema nervioso central (SNC). La THS induce la síntesis de No en mujeres menopáusicas, lo que se refleja a nivel sistémico en aumento de los niveles plasmáticos de nitritos y nitratos. El incremento de los metabolitos estables probablemente refleja una mejor producción de No en endotelio vascular, que representa mejoría de la VMF. A nivel del SNC el efecto es selectivo y asimétrico.spa
dc.description.abstractenglishThe administration of estrogens as hormone replacement therapy (HRT) in menopausal women improves mental function and emotional state, effects that may be due to the favorable action on endothelial function that is manifested by an increase in cerebral blood flow mediated by nitric oxide ( NO). However, the induction of synthesis is not limited to endothelial cells as other tissues are also stimulated, such as the brain, so the improvement seen with estrogen supplementation in higher brain functions in menopausal women may be due to a dual effect. of HRT, one due to increased blood flow and the other due to an increase in No in the central nervous system (CNS) itself. HRT induces the synthesis of No in menopausal women, which is reflected at the systemic level in increased plasma levels of nitrites and nitrates. The increase in stable metabolites probably reflects a better production of No in the vascular endothelium, which represents an improvement in VMF. At the CNS level, the effect is selective and asymmetric.spa
dc.description.degreelevelEspecializaciónspa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontents1. OBJETIVO GENERAL 1 1.1 OBJETIVOS ESPECÍFICOS 1 2. PLANTEAMIENTO DEL PROBLEMA Y JUSTIFICACIÓN 3 3. IMPACTO 1 4. MARCO TEÓRICO 13 4.1 DEFINICIÓN DE TÉRMINOS 13 4.2 MENOPAUSIA Y SISTEMA CARDIOVASCULAR 14 4.3 ACCIONES DE LOS ESTRÓGENOS SOBRE EL SISTEMA CARDIOVASCULAR. 17 4.4 METODOLOGÍA DE LA VASOD1LATAC1ÓN MEDIADA POR FLUJO 20 4.4.1 Prueba 22 4.4.2 Factores de Control en el Momento de Selección de Pacientes 24 4.5 MENOPAUSIA Y SISTEMA NERVIOSO 25 4.5.1 Menopausia y Alteraciones del Estado de Ánimo 25 4.5.2 Menopausia y Alteraciones en la Memoria 26 4.5.3 Terapia Estrogénica, Producción de ON y Sistema Nervioso 27 4.5.4 Inventario de Depresión de Beck (IDB) 28 4.6 TOMOGRAFÍA CON EMISIÓN DE FOTÓN ÚNICO (SPECT) 29 4.6.1 Estudio de Perfusión Normal 29 4.6.2 SPECT con Neuroactivación 30 5. METODOLOGÍA 32 5.1 CARACTERÍSTICAS DEL ENSAYO CLÍNICO 32 5.2 PRUEBAS REALIZADAS 34 6. ANÁLISIS ESTADÍSTICO 37 7. RESULTADOS 39 7.2 SELECCIÓN DE PACIENTES 39 7.2 CARACTERÍSTICAS DE LAS PACIENTES INCLUIDAS 40 7.3 METABOLITOS DEL ÓXIDO NÍTRICO 44 7.4 PRUEBAS DE FLUJO VASCULAR 45 7.4.1 Vasodilatación Mediada por Flujo 45 7.4.2 Variadón de la Velocidad Pico 50 7.5 PRUEBAS DE NEUROPSICOLOGÍA 52 7.5.1 Inventario de Depresión de Beck 52 7.5.2 Prueba de Memoria Reciente 53 7.6 PRUEBAS DE ACTIVIDAD CEREBRAL POR SPECT 55 8. DISCUSIÓN 60spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/18051
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programEspecialización en Radiología e Imágenes Diagnósticasspa
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dc.relation.referencesTorres M. Validez y reproductibilidad del inventarío para depresión de Beck en un hospital de Cardiología . En Enciclopedia de salud mental. Vol 14, Pag 1-7.spa
dc.relation.referencesVaques C, Sanz J. Fiabilidad y validez factorial de la versión española del Inventario de depresión de Beck. Comunicación presentada en el II Congreso de evaluación Psicológica, Barcelona, 1991.spa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsHealth sciencesspa
dc.subject.keywordsRadiologyspa
dc.subject.keywordsDiagnostic imagingspa
dc.subject.keywordsMenopausespa
dc.subject.keywordsWomenspa
dc.subject.keywordsHormone therapyspa
dc.subject.keywordsNitrogen compoundsspa
dc.subject.keywordsEstrogens (Therapeutic use)spa
dc.subject.keywordsHormone therapyspa
dc.subject.keywordsCardiovascular systemspa
dc.subject.lembCiencias médicasspa
dc.subject.lembRadiologíaspa
dc.subject.lembDiagnóstico para imágenesspa
dc.subject.lembCompuestos de nitrógenospa
dc.subject.lembEstrogenos (Uso terapeútico)spa
dc.subject.lembTerapia hormonalspa
dc.subject.lembSistema cardiovascularspa
dc.subject.proposalCiencias de la saludspa
dc.subject.proposalTerapia hormonalspa
dc.subject.proposalMenopausiaspa
dc.subject.proposalMujeresspa
dc.titleAcciones de la terapia de reemplazo hormonal a través de la vía L-Arginina óxido nítirico en el sistema cardiovascular y nervioso de mujeres menopáusicasspa
dc.title.translatedActions of hormone replacement therapy through the L-arginine nitiric oxide pathway on the cardiovascular and nervous systems of menopausal womenspa
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dc.type.driverinfo:eu-repo/semantics/masterThesis
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dc.type.localTesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TM

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