Estudio de los modelos dinámicos de la glucosa y la insulina en pacientes con diabetes mellitus tipo 1

Tibaduiza Burgos, Diego Alexander; Chio Cho, Nayibe

Estudio de los modelos dinámicos de la glucosa y la insulina en pacientes con diabetes mellitus tipo 1

dc.contributor.author	Tibaduiza Burgos, Diego Alexander
dc.contributor.author	Chio Cho, Nayibe
dc.contributor.cvlac	Tibaduiza Burgos, Diego Alexander [0000447137]	spa
dc.contributor.googlescholar	Tibaduiza Burgos, Diego Alexander [es&oi=ao]	spa
dc.contributor.orcid	Tibaduiza Burgos, Diego Alexander [0000-0002-4498-596X]	spa
dc.coverage.campus	UNAB Campus Bucaramanga	spa
dc.coverage.spatial	Colombia	spa
dc.date.accessioned	2023-09-07T14:02:15Z
dc.date.available	2023-09-07T14:02:15Z
dc.date.issued	2007
dc.description.abstract	El presente proyecto propone una revisión del estado del arte de la investigación en los modelos dinámicos de la glucosa, para poder realizar posteriormente unas simulaciones que permitan obtener un modelo de dosificación de insulina para pacientes con diabetes mellitus tipo I. Por lo que se sabe a nivel nacional no se ha realizado investigaciones en este aspecto, todo se ha encaminado desde el punto de vista médico a determinar los aspectos fisiológicos y clínicos de los pacientes con diabetes mellitas tipo I. Por otro lado, el proyecto busca proponer una metodología de identificación de parámetros de los dos modelos propuestos, basada en datos básicos del paciente, datos de ingestión y evolución de la glucosa durante un periodo de observación. Para la identificación inicial de los parámetros del modelo, se contará con información publicada en los diferentes artículos obtenida de pruebas clínicas realizadas a un grupo de pacientes con diabetes mellitus tipo I. Para la identificación y modelado se utilizarán herramientas matemáticas y técnicas de control. La realización e integración de estos modelos se realizará en una plataforma software.	spa
dc.description.abstractenglish	The present project proposes a review of the state of the art of research in dynamic glucose models, in order to subsequently carry out simulations that allow obtaining an insulin dosing model for patients with type I diabetes mellitus. As far as is known, At the national level, no research has been carried out in this aspect, everything has been directed from the medical point of view to determine the physiological and clinical aspects of patients with type I diabetes mellitus. On the other hand, the project seeks to propose a methodology for identifying parameters of the two proposed models, based on basic patient data, ingestion data and glucose evolution during an observation period. For the initial identification of the model parameters, there will be information published in the different articles obtained from clinical tests carried out on a group of patients with type I diabetes mellitus. Mathematical tools and control techniques will be used for identification and modeling. The creation and integration of these models will be carried out on a software platform.	spa
dc.description.learningmodality	Modalidad Presencial	spa
dc.description.tableofcontents	Marco Teórico Asociaciones Colombianas de Diabetes Incidencia de la Alimentación y diabetes mellitus como problema de control Diabetes y ejercicio Estado del Arte Modelos dinámicos de la Glucosa y la Insulina Simulaciones del Modelo Seleccionado Diseño de estrategia de Control Observaciones y Conclusiones Bibliografía Anexos
dc.format.mimetype	application/pdf	spa
dc.identifier.instname	instname:Universidad Autónoma de Bucaramanga - UNAB	spa
dc.identifier.reponame	reponame:Repositorio Institucional UNAB	spa
dc.identifier.repourl	repourl:https://repository.unab.edu.co	spa
dc.identifier.uri	http://hdl.handle.net/20.500.12749/21761
dc.language.iso	spa	spa
dc.publisher.faculty	Facultad Ingeniería	spa
dc.publisher.grantor	Universidad Autónoma de Bucaramanga UNAB	spa
dc.relation.references	Asociación colombiana de Diabetes (ACD). http://encolombia.com/medicina/sociedadescien/diabetes-home.htm
dc.relation.references	Fundación Diabetológica Colombiana (FDC). www.fdc.org.co.
dc.relation.references	Unired. www.unired.edu.co
dc.relation.references	Pan American Health Organization. http://www.paho.or
dc.relation.references	V. W. Bolie, “Coefficient of normal blood glucouse regulation”, Applied Physiology, Vol 16, pp 783-788, 1961.
dc.relation.references	E. Ackerman, L.C. Gateway, J.W. Rosevear y G.D. Molnar,"Model Studies of blood glucouse regulation”, Bulletin of mathematics and biophysics. Vol 27, pp. 21-35, 1965.
dc.relation.references	R.L.Lerner, D. Porte, JR. “Acute and steady-state insulin responses to glucouse in nonobese diabetic subjects”. The journal of clinical Investigation. Volume 51 July 1972.
dc.relation.references	]R.N.Bergman, C. Cobelli, Minimal modelling, partition análysis and the estimation of insulin sensivity. Federation Proc. 39(1980)110-115.
dc.relation.references	J.T. Sorensen , “A Physiologic Model of Glucouse Metabolism in Man and its use to design and asses improved insulin therapies for diabetes”, PHD. Thesis, Massachussets Institute of Technology, USA, 1985.
dc.relation.references	W.R. Puckett, “Dynamic Modelling of Diabetes Mellitus”, PHD, Thesis, University of Wisconsin —-Madison, USA, 1992.
dc.relation.references	W.R. Puckett, “Dynamic Modelling of Diabetes Mellitus”, PHD, Thesis, University of Wisconsin —-Madison, USA, 1992.
dc.relation.references	ichael E. Fisher. A Semiclosed-loop Algorithm for the Control of Blood Glucose Levels in Diabetic. IEEE Transactions on Biomedical Engineering. Vol 38. No. 1 January 1991.
dc.relation.references	]Lehmann ED. T. Deutsch. “A physiological model of glucouse-insulin interaction”. Annual International Conference of the IEEE Engineering in medicine and Biology Society. Vol. 13 No. 5, 1991.
dc.relation.references	Lehman ED, Deutsch T. “Computer assisted diabetes care: 6-years retrospective”. Comput Methods Programs Biomed. 1996 Aug, 50(3):209-30
dc.relation.references	Lehmann ED. “Application of information technology in clinical diabetes care”. Medical Informatics:Volume 21 Number 4 and Volume 22 Number 1.
dc.relation.references	R.N.Bergman. The minimal model: yesterday, today and tomorrow, in: R.N.Bergman, y.C. Lovejoys (Eds), The minimal model approach and determination of Glucouse tolerance, LSU Press, 1997, pp 3-50.
dc.relation.references	Lehman ED, Deutsch T."Comportamental models for glycemic prediction and decision-support in clinical diabetes care: promise and reality. Computer Methods and Programs in Biomedicine 56 (1998) 193-204.
dc.relation.references	]R.N.Bergman. The minimal model of glucouse regulation:a biography, in: J.Novotny,M.Green, R.Boston (Eds), Mathematical modelling in nutrition and health, Kluwer Academic/Plenum,2001
dc.relation.references	Lehmann ED, “The freeware AIDA interactive educational diabetes simulator”. MedSciMonit. 2001 May-Jun;7: 504-15
dc.relation.references	R.N.Bergman. Pathogenesis and prediction on diabetes mellitus: lessons from integrative physiology, in: Irving L. Schaeartz Lecture, Mount Sinai J. Medicine 60 (2002) 280-290
dc.relation.references	R.N.Bergman, D.T. Finegood, S.E. Kahn. The evolution of Beta cells dysfunction and insulin resistence in type 2 diabetes, Eur.J.Clin. Invest. 32(suppl.3)(2002) 35-45.
dc.relation.references	M.S Ibbini, M.A. Masadeh and M.M. Bani Amer. A fuzzy logic control technique for blood glucouse — level in diabetics. Proceeding (387) Biomechanics-2003.
dc.relation.references	G. Quiroz Compeán, A. Femat Florez. ” Estudio dinámico y de propiedades geométricas sobre el metabolismo de glucosa e insulina en diabéticos tipo l”. Trabajo de investigación de maestria. Instituto Potosino de Investigación científica y aplicada A.C. Mexico. Julio de 2005.
dc.relation.references	. Makoglou, J. Li, Y. Kuang. "Mathematical models and software tools for the glucose-insulin regulatory system and diabetes: an overview”. Applied Numerical Mathematics 56 (2006) 559-573.
dc.relation.references	D. U. Campos-Delgado*, Member, IEEE, M. Hernández-Ordoñez, R. Femat, and A. Gordillo-Moscoso. Fuzzy-Based Controller for Glucose Regulation in Type-1 Diabetic Patients by Subcutaneous Route. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 53, NO. 11, NOVEMBER 2006. pp. 2201-2210.
dc.relation.references	Owens, C. Zisser, H. Jovanovic, L. Srinivasan,B. Bonvin, D. Doyle, J. Runto-run control of blood glucose concentrations for people with type \| diabetes mellitus. Biomedical engineering, IEEE Transactions. Volume 53. Issue 6. pp 996-1005. June 2006.
dc.relation.references	Lynch, S. Wayne, B. Estimation-based Model Predictive Control of Blood Glucose in type \| diabetics: A simulation study. Proceedings of the IEEE 27'" Annual Northeast Bioengineering Conference. 2001
dc.relation.references	Dua, P. Doyle, F. Pistikopoulus, E. Model-based blood glucose control for type \| diabetes via parametric programming. IEEE Transactions on Biomedical Engineering. Vol. 53 No. 8 August 2006.
dc.relation.references	The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committe on the Diagnosis and Clasification of Diabetes Mellitus. Diabetes Care 2000; 2 3:54-s19.
dc.relation.references	E.R. Carson, C.Cobelli, and L. Finkelstein. The mathematical modelling of Metabolic and Endocrine System-Model Formulation, Identification and Validation, volume 2 of Biomedical Engineering and Health System. John-Wiley and Sons, 1983.
dc.relation.references	C. Cobelli and A. Mari. Control of diabetes with artificial systems for insulin delivery-algorithm independient limitations revealed by a modelling study. IEEE Trans. Biomed. Eng., 32(10): 840-845, October 1985.
dc.relation.references	M. GIUGLIANO, M. BOVE, AND M. GRATTAROLA. Insulin release at the molecular level: Metabolic-electrophysiological modeling of the pancreatic betacells. IEEE Eng. Mead. Biol. Mag., 47(5):611-623, May 2000.
dc.rights.accessrights	info:eu-repo/semantics/openAccess	spa
dc.rights.creativecommons	Atribución-NoComercial-SinDerivadas 2.5 Colombia	*
dc.rights.local	Abierto (Texto Completo)	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/2.5/co/	*
dc.subject.keywords	Mellitus diabetes	spa
dc.subject.keywords	Sugar in the body	spa
dc.subject.keywords	Dynamic models	spa
dc.subject.keywords	Glucose	spa
dc.subject.keywords	Dynamic	spa
dc.subject.lemb	Diabetes mellitus	spa
dc.subject.lemb	Azúcar en el organismo	spa
dc.subject.lemb	Glucosa	spa
dc.subject.lemb	Dinámica	spa
dc.subject.proposal	Modelos dinámicos	spa
dc.title	Estudio de los modelos dinámicos de la glucosa y la insulina en pacientes con diabetes mellitus tipo 1	spa
dc.title.translated	Study of the dynamic models of glucose and insulin in patients with type 1 diabetes mellitus	spa
dc.type	Research report	eng
dc.type.coar	http://purl.org/coar/resource_type/c_18ws
dc.type.coarversion	http://purl.org/coar/version/c_ab4af688f83e57aa	spa
dc.type.driver	info:eu-repo/semantics/workingPaper	spa
dc.type.hasversion	info:eu-repo/semantics/acceptedVersion	spa
dc.type.local	Informe de investigación	spa
dc.type.redcol	http://purl.org/redcol/resource_type/IFI