Asociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversal

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dc.contributor.advisorWandurraga Sánchez, Edwin Antonio
dc.contributor.advisorVergara Rueda, Jessica Inés
dc.contributor.advisorSerrano, Sergio
dc.contributor.advisorTovar Fierro, Germán
dc.contributor.advisorAmaya Muñoz, María Camila
dc.contributor.advisorLogreira Castillo, Alejandra
dc.contributor.apolounabWandurraga Sánchez, Edwin Antonio [edwin-antonio-wandurraga-sánchez]spa
dc.contributor.authorDel Castillo Pinto, Alejandra María
dc.contributor.cvlacWandurraga Sánchez, Edwin Antonio [0001475567]spa
dc.contributor.googlescholarWandurraga Sánchez, Edwin Antonio [es&oi=ao]spa
dc.contributor.orcidWandurraga Sánchez, Edwin Antonio [000-0002-0529-2343]spa
dc.contributor.orcidDel Castillo Pinto, Alejandra María [0000-0002-0292-9329]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialBucaramanga (Santander, Colombia)spa
dc.coverage.temporalJunio - diciembre 2023spa
dc.date.accessioned2024-07-04T19:41:13Z
dc.date.available2024-07-04T19:41:13Z
dc.date.issued2024-06-27
dc.degree.nameEspecialista en Dermatologíaspa
dc.description.abstractLos acrocordones son tumores fibroepiteliales comunes en la dermis y están asociados con factores como la predisposición genética, diabetes mellitus, acromegalia, obesidad y síndrome metabólico. La posible relación entre los acrocordones y los pólipos del colon (PC) ha generado controversia, destacándose la sobreexpresión del IGF-1 y polimorfismos del gen IGF-1 como posibles vínculos fisiopatológicos. Realizamos un estudio transversal en la Fundación oftalmológica de Santander – Fosunab, evaluando 210 sujetos, encontrando una prevalencia de acrocordones del 49% y de pólipos del colon del 16.7%. Aunque la asociacion no fue estadisticamente significativa entre los pólipos del colon y los acrocordones, se observó una relación entre los acrocordones y obesidad abdominal, antecedentes de enfermedad cardiovascular, sugiriendo la resistencia a la insulina como un denominador común. El estudio resalta la necesidad de investigaciones futuras sobre la conexión y relevancia clínica de estas condiciones.spa
dc.description.abstractenglishSkin tags are common fibroepithelial tumors in the dermis and are associated with factors such as genetic predisposition, diabetes mellitus, acromegaly, obesity and metabolic syndrome. The possible relationship between skin tags and colon polyps (CP) has generated controversy, highlighting the overexpression of IGF-1 and polymorphisms of the IGF-1 gene as possible pathophysiological links. We carried out a cross-sectional study at the Santander Ophthalmology Foundation – Fosunab, evaluating 210 subjects, finding a prevalence of skin tags of 49% and colon polyps of 16.7%. Although the association was not statistically significant between colon polyps and skin tags, a relationship was observed between skin tags and abdominal obesity, history of cardiovascular disease, suggesting insulin resistance as a common denominator. The study highlights the need for future research into the connection and clinical relevance of these conditions.spa
dc.description.degreelevelEspecializaciónspa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontentsPortada 1 Pregunta de investigación 3 Resumen 4 Justificación 5 Marco teórico 7 Estado del arte 13 Objetivos 25 Objetivo general 25 Objetivos específicos 25 Metodología 25 Tipo de estudio 25 Población 25 Criterios de inclusion y exclusion 25 Cálculo tamaño de muestra 26 Muestreo 27 Recolección de la información 27 Variables 28 Plan de análisis de datos 34 Consideraciones éticas 35 Resultados esperados 36 Impactos esperados 38 Resultados 39 Características sociodemográficas de la población de estudio 39 Características clínicas de la población de estudio 42 Análisis comparativo según la presencia de acrocordones: 49 Análisis comparativo según la presencia de pólipos 56 Análisis de asociación entre la presencia de acrocordones y pólipos en la población de estudio 63 Discusión 64 Conclusiones 68 Referencias bibliográficas 69 Anexos 72spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/25316
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programEspecialización en Dermatologíaspa
dc.publisher.programidEDER-356
dc.relation.references1. Bolognia J, Schaffer J, Cerroni L. Dermatología: Principales diagnósticos y tratamientos. . 2016.spa
dc.relation.references2. Pandey A, Sonthalia S. Skin Tags. 2023.spa
dc.relation.references3. Hassan A, Mohammad L, Nassar A, Abd-Elazeem M, Abaza M. Immunohistochemical study of estrogen and androgen receptors in skin tags. J Microsc Ultrastruct. 2013;1(3):76.spa
dc.relation.references4. El Safoury O, Ibrahim M. A clinical evaluation of skin tags in relation to obesity, type 2 diabetis mellitus, age, and sex. Indian J Dermatol. 2011;56(4):393.spa
dc.relation.references5. Jindal A, Patel N, Shah R. Acrochordons as a cutaneous sign of metabolic syndrome: A case-control study. Ann Med Health Sci Res. 2014;4(2):202.spa
dc.relation.references6. Tripathy T, Singh BhabaniSTP, Kar B. Association of skin tag with metabolic syndrome and its components: A case–control study from Eastern India. Indian Dermatol Online J. 2019;10(3):284.spa
dc.relation.references7. Kurtipek GS, Duran C, Kutlu O, Ataseven A, Akyürek FT, Kurku H, et al. The frequency of metabolic syndrome in patients with acrochordons. Bangladesh Journal of Medical Science. 2017 Jan 16;16(1):35–41.spa
dc.relation.references8. Ben-Shlomo A, Melmed S. Skin manifestations in acromegaly. Clin Dermatol. 2006 Jul;24(4):256–9.spa
dc.relation.references9. Zaki AM, Elshahed AR, Diab MR, Hasan MS, Elsaie ML. Prevalence and predictors of colon polyps in patients with skin tags: A cross sectional study. J Cosmet Dermatol. 2022 Apr;21(4):1547–53.spa
dc.relation.references10. Parga J, Otero Regino W, Gómez Zuleta MA. Prevalencia y características histológicas de los pólipos diminutos del recto y del sigmoides en una población colombiana. Rev Colomb Gastroenterol. 2020 Mar 27;35(1):25–32.spa
dc.relation.references11. Ministerio de Salud y Protección Social. Guía de Práctica Clínica para la detección temprana, diagnóstico, tratamiento, seguimiento y rehilitación de pacientes con diagnóstico de cáncer de colon y recto. 2013.spa
dc.relation.references12. López-Jiménez EC, Ruiz-Rodríguez R, Sánchez-Carpintero I. Infarcted Giant Skin Tag. Actas Dermo-Sifiliográficas (English Edition). 2019 Sep;110(7):e17.spa
dc.relation.references13. Köseoğlu HG, Bozca BC, Başsorgun Cİ, Sarı R, Akbaş SH, Karakaş AA. The role of insulin-like growth factor in Acrochordon Etiopathology. BMC Dermatol. 2020 Dec 3;20(1):14.spa
dc.relation.references14. Arora S, Gupta S, Aggarwal R, Gupta S. Human papillomavirus and skin tags: Is there any association? Indian J Dermatol Venereol Leprol. 2008;74(3):222.spa
dc.relation.references15. Antunes A, Rossel B, Adriaens E. Efficacy Evaluation of the Pixie® Skin Tag Cryogenic Device on Skin Tags in a Prospective, Single-Blinded, Randomized, Comparative Clinical Trial. Dermatol Ther (Heidelb). 2021 Jun 21;11(3):995–1007.spa
dc.relation.references16. Dabbous HK, Mohamed YAER, El-Folly RF, El-Talkawy MD, Seddik HE, Johar D, et al. Evaluation of Fecal M2PK as a Diagnostic Marker in Colorectal Cancer. J Gastrointest Cancer. 2019 Sep 15;50(3):442–50.spa
dc.relation.references17. Raab M, Sanhaji M, Matthess Y, Hörlin A, Lorenz I, Dötsch C, et al. PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells. Nat Commun. 2018 Mar 16;9(1):1106.spa
dc.relation.references18. Castro J, Cuatrecasas M, Balaguer F, Ricart E, Pellisé M. Serrated polyposis syndrome associated with long-standing inflammatory bowel disease. Revista Española de Enfermedades Digestivas. 2017;109.spa
dc.relation.references19. Meseeha M, Attia M. Colon Polyps. 2023.spa
dc.relation.references20. Shussman N, Wexner SD. Colorectal polyps and polyposis syndromes. Gastroenterol Rep (Oxf). 2014 Feb 1;2(1):1–15.spa
dc.relation.references21. Bien SA, Su YR, Conti D V., Harrison TA, Qu C, Guo X, et al. Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer. Hum Genet. 2019 Apr 28;138(4):307–26.spa
dc.relation.references22. Malekpour H, Heidari MH, Vafaee R, Moravvej Farshi H, Khodadoostan M. Gene expression analysis of colon high-grade dysplasia revealed new molecular mechanism of disease. Gastroenterol Hepatol Bed Bench. 2018;11(Suppl 1):S111–7.spa
dc.relation.references23. Lotfollahzadeh S, Recio-Boiles A, Cagir B. Colon Cancer. StatPearls. 2022;spa
dc.relation.references24. Ashktorab H, Brim H. DNA Methylation and Colorectal Cancer. Curr Colorectal Cancer Rep. 2014 Dec 31;10(4):425–30.spa
dc.relation.references25. Worthley DL, Leggett BA. Colorectal cancer: molecular features and clinical opportunities. Clin Biochem Rev. 2010 May;31(2):31–8.spa
dc.relation.references26. Kang H, Thoufeeq M. Size of colorectal polyps determines time taken to remove them endoscopically. Endosc Int Open. 2018 May 8;06(05):E610–5.spa
dc.relation.references27. Rojas AER. Cáncer de colón y dieta. Revista Colombiana de Cancerología. 2015 Oct;19(4):191–2.spa
dc.relation.references28. Fondo Colombiano de Enfermedades de Alto Costo. Situación del cáncer en la población adulta atendida en el SGSSS de Colombia 2018. Bogota, Colombia; 2018.spa
dc.relation.references29. Vanegas DP, Ramírez López LX, Limas Solano LM, Pedraza Bernal AM, Monroy Díaz AL. Revisión: Factores asociados a cáncer colorrectal. Revista Médica de Risaralda. 2020 Jun 30;26(1).spa
dc.relation.references30. Cortés A, Bravo LE, García LS, Collazos P. Incidencia, mortalidad y supervivencia por cáncer colorrectal en Cali, Colombia, 1962-2012. Salud Publica Mex. 2014 Aug 13;56(5):457.spa
dc.relation.references31. Sninsky JA, Shore BM, Lupu G V., Crockett SD. Risk Factors for Colorectal Polyps and Cancer. Gastrointest Endosc Clin N Am. 2022 Apr;32(2):195–213.spa
dc.relation.references32. Kune GabrielA, Gooey J, Penfold C, Sali A. ASSOCIATION BETWEEN COLORECTAL POLYPS AND SKIN TAGS. The Lancet. 1985 Nov;326(8463):1062–3.spa
dc.relation.references33. Brendler SJ, Watson RD, Katon RM, Parsons ME, Howatt JL. Skin Tags Are Not a Risk Factor for Colorectal Polyps. J Clin Gastroenterol. 1989 Jun;11(3):299–302.spa
dc.relation.references34. McKusick VA. Genetic Factors in Intestinal Polyposis. JAMA: The Journal of the American Medical Association. 1962 Oct 20;182(3):271.spa
dc.relation.references35. LEAVITT J. Skin Tags: A Cutaneous Marker for Colonic Polyps. Ann Intern Med. 1983 Jun 1;98(6):928.spa
dc.relation.references36. Rasi A, Soltani-Arabshahi R, Shahbazi N. Skin tag as a cutaneous marker for impaired carbohydrate metabolism: a case–control study. Int J Dermatol. 2007 Nov;46(11):1155–9.spa
dc.relation.references37. Piette AM, Meduri B, Fritsch J, Fermanian J, Piette JC, Chapman A. Do skin tags constitute a marker for colonic polyps? Gastroenterology. 1988 Oct;95(4):1127–9.spa
dc.relation.references38. Chobanian SJ. Skin tags and colonic polyps—a gastroenterologistIs perspective. J Am Acad Dermatol. 1987 Feb;16(2):407–9.spa
dc.relation.references39. LUK GD. Colonic Polyps and Acrochordons (Skin Tags) Do Not Correlate in Familial Colonic Polyposis Kindreds. Ann Intern Med. 1986 Feb 1;104(2):209.spa
dc.relation.references40. Adibi N, Robati R. Skin and metabolic syndrome: A review of the possible associations. Journal of Research in Medical Sciences. 2021;26(1):16.spa
dc.relation.references41. Pignone M, Rich M, Teutsch SM, Berg AO, Lohr KN. Screening for Colorectal Cancer in Adults at Average Risk: A Summary of the Evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2002 Jul 16;137(2):132.spa
dc.relation.references42. Akhtar AJ, Zhuo J. Non-association between acrochordons and colonic polyps in a minority population. J Natl Med Assoc. 2003 Aug;95(8):746–9.spa
dc.relation.references43. KLEIN I. Colonie Polyps in Patients with Acromegaly. Ann Intern Med. 1982 Jul 1;97(1):27.spa
dc.relation.references44. Jowkar F, Fallahi A, Namazi M. Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? Journal of the European Academy of Dermatology and Venereology. 2010 Jan;24(1):73–4.spa
dc.relation.references45. Oran M, Erfan G, Mete R, Yanik ME, Yildirim O, Aydin M, et al. Association of colon adenomas and skin tags: coincidence or coexistence? Eur Rev Med Pharmacol Sci. 2014;18(7):1073–7.spa
dc.relation.references46. Foltyn W, Kos-Kudla B, Strzelczyk J, Matyja V, Karpe J, Rudnik A, et al. Is there any relation between hyperinsulinemia, insulin resistance and colorectal lesions in patients with acromegaly? Neuro Endocrinol Lett. 2008 Feb;29(1):107–12.spa
dc.relation.references47. Nishii T, Kono S, Abe H, Eguchi H, Shimazaki K, Hatano B, et al. Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men. Japanese Journal of Cancer Research. 2001 Aug;92(8):836–40.spa
dc.relation.references48. McKeown-Eyssen G. Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol Biomarkers Prev. 1994 Dec;3(8):687–95.spa
dc.relation.references49. Giovannucci E. Insulin and colon cancer. Cancer Causes and Control. 1995 Mar;6(2):164–79.spa
dc.relation.references50. Beitler M, Eng A, Kilgour M, Lebwohl M. Association between acrochordons and colonic polyps. J Am Acad Dermatol. 1986 Jun;14(6):1042–4.spa
dc.relation.references51. Gould BE, Ellison RC, Greene HL, Bernhard JD. Lack of association between skin tags and colon polyps in a primary care setting. Arch Intern Med. 1988 Aug;148(8):1799–800.spa
dc.relation.references52. Varma JR. Skin tags--a marker for colon polyps? J Am Board Fam Pract. 1990;3(3):175–80.spa
dc.relation.references53. Radack K, Park S. Is there a valid association between skin tags and colonic polyps. J Gen Intern Med. 1993 Aug;8(8):413–21.spa
dc.relation.references54. Jowkar F, Fallahi A, Namazi MR. Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? J Eur Acad Dermatol Venereol. 2010 Jan;24(1):73–4.spa
dc.relation.references55. Agarwal P, Rai P, Jain M, Mishra S, Singh U, Gupta S. Prevalence of colonic polyp and itsspa
dc.relation.references56. Köseoğlu HG, Bozca BC, Başsorgun Cİ, Sarı R, Akbaş SH, Karakaş AA. The role of insulin-like growth factor in Acrochordon Etiopathology. BMC Dermatol. 2020 Dec 3;20(1):14.spa
dc.relation.references57. Alagaratnam S, Loizidou M, Yang S yu, Fuller B, Ramesh B. Increased expression of IGF-1Ec with increasing colonic polyp dysplasia and colorectal cancer. J Cancer Res Clin Oncol. 2020 Nov 8;146(11):2861–70.spa
dc.relation.references58. Fang CEH, Crowe C, Murphy A, O’Donnell M, Finucane FM. Cross-sectional study of the association between skin tags and vascular risk factors in a bariatric clinic-based cohort of Irish adults with morbid obesity. BMC Res Notes. 2020 Dec 16;13(1):156.spa
dc.relation.references59. Plascencia Gómez A, Vega Memije ME, Torres Tamayo M, Rodríguez Carreón AA. Dermatosis en pacientes con sobrepeso y obesidad y su relación con la insulina. Actas Dermosifiliogr. 2014 Mar;105(2):178–85.spa
dc.relation.references60. Cano D, Otero W, Gómez M, Marulanda H. [Comparative prevalence of adenomatous polyps in people aged 45 to 49 years and in people over 50 years of age in a Colombian population: a case-control study]. Rev Gastroenterol Peru. 2021;41(3):150–5.spa
dc.relation.references61. Restrepo C, Correa P, Duque E, Cuello C. Polyps in a low-risk colonic cancer population in Colombia, South America. Dis Colon Rectum. 1981;24(1):29–36.spa
dc.relation.references62. Mella JM, González R, Fischer C, Panigadi GN, Pereyra L, Luna P, et al. Tu1545 Risk of Colorectal Polyps in Patients With Skin Lesions, a Prospective Case-Control Pilot Study. Gastrointest Endosc. 2011 Apr;73(4):AB443.spa
dc.relation.uriapolohttps://apolo.unab.edu.co/en/persons/edwin-antonio-wandurraga-s%C3%A1nchezspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsSkin Tagsspa
dc.subject.keywordsColon polypsspa
dc.subject.keywordsDermatologyspa
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsMedicinespa
dc.subject.keywordsPolyps (Pathology)spa
dc.subject.keywordsColon (Anatomy Cancer)spa
dc.subject.keywordsNeurocutaneous disordersspa
dc.subject.lembDermatologíaspa
dc.subject.lembCiencias médicasspa
dc.subject.lembMedicinaspa
dc.subject.lembPólipos (Patología)spa
dc.subject.lembColon (Anatomía Cáncer)spa
dc.subject.lembTrastornos neurocutáneosspa
dc.subject.proposalAcrocordonesspa
dc.subject.proposalPólipos del colonspa
dc.titleAsociacion entre la presencia de acrocordones y pólipos del colon un estudio de corte transversalspa
dc.title.translatedAssociation between the presence of skin tags and colon polyps: a cross-sectional studyspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TM

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