Determinación de eficacia y seguridad del entrecruzamiento del colágeno corneal (crosslinking) a 5 años en pacientes con queratocono en el Centro Oftalmológico Virgilio Galvis

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dc.contributor.advisorGalvis Ramírez, Virgiliospa
dc.contributor.advisorTello Hernández, Alejandrospa
dc.contributor.advisorCarreño Jaimes, Néstor Ivánspa
dc.contributor.advisorOchoa Vera, Miguel Enriquespa
dc.contributor.authorOrtiz Zapata, Álvaro Ivánspa
dc.contributor.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001009125;https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000552453*
dc.contributor.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000898465*
dc.contributor.googlescholarhttps://scholar.google.es/citations?hl=es#user=puxZHKYAAAAJ;https://scholar.google.es/citations?hl=es#user=CZOaBDoAAAAJ*
dc.contributor.orcidhttps://orcid.org/0000-0002-4552-3388*
dc.contributor.orcidhttps://orcid.org/0000-0002-8986-7510*
dc.contributor.researchgatehttps://www.researchgate.net/profile/Virgilio_Galvis*
dc.contributor.researchgatehttps://www.researchgate.net/profile/Miguel_Ochoa7*
dc.contributor.researchgatehttps://www.researchgate.net/profile/Alvaro_Ortiz_Zapata*
dc.contributor.researchgroupGrupo de Investigaciones Clínicasspa
dc.contributor.scopushttps://www.scopus.com/authid/detail.uri?authorId=6603664598;https://www.scopus.com/authid/detail.uri?authorId=55963715000*
dc.contributor.scopushttps://www.scopus.com/authid/detail.uri?authorId=36987156500*
dc.coverageBucaramanga (Colombia)spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.date.accessioned2020-06-26T20:01:39Z
dc.date.available2020-06-26T20:01:39Z
dc.date.issued2014-09
dc.degree.nameEspecialista en Oftalmologíaspa
dc.description.abstractEl presente estudio tiene como objetivo evaluar la eficacia, efectividad y seguridad del Crosslinking en la detención de la progresión del queratocono a largo plazo, ya que una detección temprana conjuntamente con una conducta terapéutica segura y eficaz ayudaran a detener la progresión de este tipo de patología previniendo la incapacidad visual de las personas y otras complicaciones, y que al ser un procedimiento sencillo y barato en el que se alteran las propiedades corneales produciendo un “Envejecimiento Corneal Prematuro”, con un índice de complicaciones bajas, pero que a su vez pueden llegar a ser severas dependiendo del estadio clínico de la enfermedad. Teniendo en cuenta que las alternativas terapéuticas para esta entidad nosológica tienden a tener una baja eficacia por la misma progresión de la enfermedad, el disconfort por parte del paciente y las complicaciones visuales, repercuten en el desempeño de su vida diaria.spa
dc.description.abstractenglishThe present study aims to evaluate the efficacy, effectiveness and safety of Crosslinking in the arrest of the progression of keratoconus in the long term, since an early detection together with a safe and effective therapeutic behavior will help to stop the progression of this type of pathology preventing the visual disability of people and other complications, and that being a simple and cheap procedure in which the corneal properties are altered, producing a "Premature Corneal Aging", with a low rate of complications, but which in turn can reach to be severe depending on the clinical stage of the disease. Taking into account that the therapeutic alternatives for this nosological entity tend to have a low efficacy due to the same progression of the disease, the discomfort on the part of the patient and the visual complications, they affect the performance of their daily life.eng
dc.description.degreelevelEspecializaciónspa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontents1. Introducción 2. Marco Teórico 2.1. Principio Básico 2.2. Estudios de Laboratorio 2.2.1. Efectos Mecánicos 2.2.2. Efectos Termo Mecánicos 2.2.3. Efectos Morfológicos 2.2.4. Efectos en Resistencia a Colagenasas 2.2.5. Efectos en Queratocitos 2.2.6. Localización del Efecto Principal 2.3. Riesgos y Efectos Secundarios 2.4. Estudios Clínicos 2.5. Clasificación del Queratocono 2.6. Indicaciones del Crosslinking 2.7. Técnica Quirúrgica 2.8. Complicaciones 3. Hipótesis 4. Objetivos 4.1. Objetivo General 4.2. Objetivos Específicos 5. Metodología 5.1. Tipo de Estudio 5.2. Universo y Muestra 5.3. Población 5.4. Criterios de Inclusión 5.5. Criterios de Exclusión 6. Consideraciones Éticas 7. Resultados 8. Discusión 9. Conclusiones 10. Referencias bibliográficas 11. Anexos 11.1.Aval del Comité de Ética FOSCAL (CEI – FOSCAL)spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/1773
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programEspecialización en Oftalmologíaspa
dc.relation.referencesOrtiz Zapata, Álvaro Iván (2014). Determinación de eficacia y seguridad del entrecruzamiento del colágeno corneal (crosslinking) a 5 años en pacientes con queratocono en el Centro Oftalmológico Virgilio Galvis. Bucaramanga (Colombia) : Universidad Autónoma de Bucaramanga UNABspa
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dc.relation.references38. Krueger RR, Ramos-Esteban JC, Kanellopoulos AJ. Staged intrastromal delivery of riboflavin with UVA cross-linking in advanced bullous keratopathy: Laboratory investigation and first clinical case. J Refract Surg. 2008 Sep; 24(7):S730-6.spa
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dc.relation.references43. Kymionis GD, Bouzoukis DI, Diakonis VF, Portaliou DM, Pallikaris AI, Yoo SH. Diffuse lamellar keratitis after corneal crosslinking in a patient with post-laser in situ keratomileusis corneal ectasia. J Cataract Refract Surg. 2007 Dec; 33 (12):2135-7.spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsPediatric ophthalmologyeng
dc.subject.keywordsVision disorder in childreneng
dc.subject.keywordsCorneal diseaseseng
dc.subject.keywordsVision disorderseng
dc.subject.keywordsMedicineeng
dc.subject.keywordsOphthalmologyeng
dc.subject.keywordsInvestigationseng
dc.subject.keywordsPatientseng
dc.subject.keywordsKeratoconuseng
dc.subject.keywordsDecreased visual acuityeng
dc.subject.lembOftalmología pediátricaspa
dc.subject.lembTrastorno de la visión en niñosspa
dc.subject.lembEnfermedades de la córneaspa
dc.subject.lembTrastornos de la visiónspa
dc.subject.lembMedicinaspa
dc.subject.lembOftalmologíaspa
dc.subject.lembInvestigacionesspa
dc.subject.lembPacientesspa
dc.subject.proposalCrosslinking
dc.subject.proposalQueratocono
dc.subject.proposalDisminución de la agudeza visual
dc.titleDeterminación de eficacia y seguridad del entrecruzamiento del colágeno corneal (crosslinking) a 5 años en pacientes con queratocono en el Centro Oftalmológico Virgilio Galvisspa
dc.title.translatedDetermination of efficacy and safety of corneal collagen crosslinking at 5 years in patients with keratoconus at the Virgilio Galvis Ophthalmological Centereng
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TM

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