Efecto del compuesto ácido poliláctico/policaprolactona y la geometría en stents biodegradables impresos 3D para el tratamiento de aterosclerosis

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dc.contributor.advisorEscobar Jaramillo, Mateo
dc.contributor.advisorSolarte David, Víctor Alfonso
dc.contributor.apolounabEscobar Jaramillo, Mateo [mateo-escobar-jaramillo]spa
dc.contributor.apolounabSolarte David, Víctor Alfonso [víctor-alfonso-solarte-david]spa
dc.contributor.authorBarrientos Contreras, Ana María
dc.contributor.authorManjarres Campo, Shanny Esther
dc.contributor.authorSerrano Jaimes, María Victoria
dc.contributor.cvlacEscobar Jaramillo, Mateo [0001468933]spa
dc.contributor.cvlacSolarte David, Víctor Alfonso [1329391]spa
dc.contributor.googlescholarEscobar Jaramillo, Mateo [es&oi=ao]spa
dc.contributor.orcidSolarte David, Víctor Alfonso [0000-0002-9856-1484]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialColombiaspa
dc.date.accessioned2025-02-20T16:41:36Z
dc.date.available2025-02-20T16:41:36Z
dc.date.issued2025-01-23
dc.degree.nameIngeniero Biomédicospa
dc.description.abstractEn la actualidad la implantación de stents convencionales para el tratamiento de la aterosclerosis plantea diversos desafíos en el ámbito médico, debido a los efectos adversos que pueden surgir tras la implantación. Esto ha impulsado la búsqueda de alternativas más seguras, como los stents biodegradables fabricados con polímeros reabsorbibles, en los que tanto el material como la geometría de las celdas desempeñan un papel importante. Este proyecto tiene como objetivo analizar el efecto de la relación de ácido poliláctico (PLA) y policaprolactona (PCL) en el comportamiento mecánico y el tiempo de degradación de stents impresos en 3D. Para ello, se diseñaron y fabricaron stents con diferentes concentraciones de estos materiales: PLA 100%, PLA 75% PCL 25%, PLA 50% PCL 50%, PLA 25% PCL 75%, y PCL 100%. Estos fueron fabricados teniendo en cuenta la geometría de celda Elixir, la cual fue la que presentó un desempeño destacable durante simulaciones de elementos finitos en comparación a otros diseños conocidos. Las propiedades mecánicas de los stents impresos 3D se analizaron a través de ensayos de tracción, mientras que el proceso de degradación se estudió mediante el cambio de masa y pH en condiciones controladas.spa
dc.description.abstractenglishCurrently, the implantation of conventional stents for the treatment of atherosclerosis has several challenges in the medical field, due to the adverse effects that can arise after implantation. This has prompted the search for safer alternatives, such as biodegradable stents made of resorbable polymers, in which both the material and the geometry of the cells play an important role. This project aims to analyze the effect of the ratio of polylactic acid (PLA) and polycaprolactone (PCL) on the mechanical behavior and degradation time of 3D printed stents. For this purpose, stents were designed and fabricated with different concentrations of these materials: PLA 100%, PLA 75% PCL 25%, PLA 50% PCL 50%, PLA 25% PCL 75%, and PCL 100%. These were fabricated considering the Elixir cell geometry, which was the one that presented outstanding performance during finite element simulations compared to other known designs. The mechanical properties of the 3D printed stents were analyzed through tensile tests, while the degradation process was studied by mass and pH change under controlled conditions.spa
dc.description.degreelevelPregradospa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontentsCAPITULO I ........................................................................................................................17 Aspectos Generales...............................................................................................................17 Descripción del problema.......................................................................................................... 17 Justificación............................................................................................................................... 18 Pregunta problema..................................................................................................................... 19 Objetivos................................................................................................................................... 20 Objetivo General.................................................................................................................... 20 Objetivos Específicos............................................................................................................ 20 Limitaciones y delimitaciones................................................................................................... 20 CAPITULO II.......................................................................................................................22 Marco Teórico, Marco Legal y Estado del Arte....................................................................22 Marco Teórico ........................................................................................................................... 22 Generalidades del Sistema Cardiovascular............................................................................ 22 Stents ..................................................................................................................................... 25 Impresión 3D ......................................................................................................................... 26 Polímeros biodegradables...................................................................................................... 28 PLA y PCL en aplicaciones cardiovasculares ....................................................................... 29 Marco Legal .............................................................................................................................. 30 Normas Nacionales................................................................................................................ 31 Ley 23 de 1982................................................................................................................... 31 Resolución 8430 de 1993................................................................................................... 31 Decreto 4725 de 2005 ........................................................................................................ 31 Decreto 351 de 2014 .......................................................................................................... 32 Decreto 1036 de 2018 ........................................................................................................ 32 Normas Internacionales......................................................................................................... 32 Norma internacional ISO 10993-13................................................................................... 32 Norma internacional ISO 35001-19................................................................................... 32 Norma internacional ASTM D638-14 ............................................................................... 33 Norma internacional ASTM F2902-16 .............................................................................. 33 Norma internacional ASTM D2990-17 ............................................................................. 33 Estado del Arte .......................................................................................................................... 34 CAPITULO III......................................................................................................................36 Metodología ..........................................................................................................................36 Materiales.................................................................................................................................. 36 Métodos..................................................................................................................................... 36 Selección de geometría a replicar.......................................................................................... 36 Revisión de literatura ......................................................................................................... 36 Replicado de los diseños preseleccionados por medio de software CAD ......................... 37 Aplicación del análisis de elementos finitos en los diseños replicados............................. 39 Determinación de la geometría con el mejor comportamiento mecánico.......................... 40 Creación de pellets................................................................................................................. 41 Fabricación de pellets ........................................................................................................ 41 Caracterización dimensional de los pellets........................................................................ 42 Fabricación de mallas de stents............................................................................................. 42 Aplicación de pruebas mecánicas en los stents..................................................................... 43 Aplicación de pruebas de degradación en los stents.............................................................. 45 Análisis estadístico.................................................................................................................... 46 CAPITULO IV......................................................................................................................49 Resultados y Discusión.........................................................................................................49 Selección de geometría a replicar.......................................................................................... 49 Revisión de literatura ......................................................................................................... 49 Replicado de los diseños preseleccionados por medio de software CAD ......................... 49 Aplicación del análisis de elementos finitos en los diseños replicados............................. 51 Determinación de la geometría con el mejor comportamiento mecánico.......................... 59 Creación de pellets ................................................................................................................ 59 Fabricación de pellets ........................................................................................................ 59 Fabricación de stents.......................................................................................................... 62 Aplicación de pruebas mecánicas en los stents impresos...................................................... 64 Aplicación de ensayos de degradación en los stents impresos.............................................. 68 Ensayos de degradación mediante la evaluación del cambio de masa .............................. 68 Ensayos de degradación mediante la evaluación del cambio de pH.................................. 71 Análisis estadístico ................................................................................................................ 73 Análisis Descriptivo........................................................................................................... 73 Análisis ANOVA................................................................................................................ 77 CAPITULO V.......................................................................................................................81 Conclusiones y recomendaciones.........................................................................................81 Bibliografía ...........................................................................................................................84spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/28412
dc.language.isospaspa
dc.publisher.facultyFacultad Ingenieríaspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programPregrado Ingeniería Biomédicaspa
dc.publisher.programidIBM-1788
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dc.relation.referencesTidwell, K., Harriet, S., Barot, V., Bauer, A., Vaughan, M. B., & Hossan, M. R. (2021). Design and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms. Bioengineering, 8(11), 183. https://doi.org/10.3390/bioengineering8110183spa
dc.relation.referencesTorki, M. M., Hassanajili, S., & Jalisi, M. M. (2020). Design optimizations of PLA stent structure by FEM and investigating its function in a simulated plaque artery. Mathematics and Computers in Simulation, 169, 103–116. https://doi.org/10.1016/j.matcom.2019.09.011spa
dc.relation.referencesTong, X., Zhang, Z., Fu, K., Li, Y., Cao, B., Wang, W., & Chen, B. (2023). Achieving high mechanical properties of biodegradable vascular stents by four-axis 3D printing system and heat treatment. Materials Letters, 341, 134261. https://doi.org/10.1016/j.matlet.2023.134261spa
dc.relation.referencesVelasco, E. G., & Revelo, D. A. (2019). 3D printing: the new industrial revolution. I+ T+ C- Research, Technology and Science, 1(13), 60–71. Retrieved from https://revistas.unicomfacauca.edu.co/ojs/index.php/itc/article/view/itc2019_pag_60_71spa
dc.relation.referencesWachirahuttapong, S., Thongpin, C., & Sombatsompop, N. (2016). Effect of PCL and compatibility contents on the morphology, crystallization and mechanical properties of PLA/PCL blends. Energy Procedia, 89, 198–206. https://doi.org/10.1016/j.egypro.2016.05.026spa
dc.relation.referencesWen, Y., Li, Y., Yang, R., Chen, Y., Shen, Y., Liu, Y., Liu, X., Zhang, B., & Li, H. (2024). Biofunctional coatings and drug-coated stents for restenosis therapy. Materials Today Bio, 101259. https://doi.org/10.1016/j.mtbio.2024.101259spa
dc.relation.referencesZaaba, N. F., & Jaafar, M. (2020). A review on degradation mechanisms of polylactic acid: Hydrolytic, photodegradative, microbial, and enzymatic degradation. Polymer Engineering & Science, 60(9), 2061–2075. https://doi.org/10.1002/pen.25511spa
dc.relation.referencesZong, J., He, Q., Liu, Y., Qiu, M., Wu, J., & Hu, B. (2022). Advances in the development of biodegradable coronary stents: A translational perspective. Materials Today Bio, 100368. https://doi.org/10.1016/j.mtbio.2022.100368spa
dc.relation.uriapolohttps://apolo.unab.edu.co/en/persons/mateo-escobar-jaramillospa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsBiomedical engineeringspa
dc.subject.keywordsEngineeringspa
dc.subject.keywordsMedical electronicsspa
dc.subject.keywordsBiological physicsspa
dc.subject.keywordsBioengineeringspa
dc.subject.keywordsMedical instruments and apparatusspa
dc.subject.keywordsMedicinespa
dc.subject.keywordsBiomedicalspa
dc.subject.keywordsClinical engineeringspa
dc.subject.keywordsBiomaterialsspa
dc.subject.keywordsBiocompatibilityspa
dc.subject.keywordsBioprintingspa
dc.subject.keywordsDegradationspa
dc.subject.keywordsMechanical propertiesspa
dc.subject.keywordsPolymersspa
dc.subject.keywordsBiodegradabilityspa
dc.subject.keywordsPolylactic acidspa
dc.subject.keywordsBiodegradable plasticsspa
dc.subject.keywordsThree-dimensional printingspa
dc.subject.lembIngeniería biomédicaspa
dc.subject.lembIngenieríaspa
dc.subject.lembBiofísicaspa
dc.subject.lembBioingenieríaspa
dc.subject.lembMedicinaspa
dc.subject.lembBiomédicaspa
dc.subject.lembÁcido polilácticospa
dc.subject.lembPlásticos biodegradablesspa
dc.subject.lembImpresión 3Dspa
dc.subject.proposalBiomaterialesspa
dc.subject.proposalBiocompatibilidadspa
dc.subject.proposalIngeniería biomédicaspa
dc.subject.proposalIngenieríaspa
dc.subject.proposalBioingenieríaspa
dc.subject.proposalMedicinaspa
dc.subject.proposalBiomédicaspa
dc.subject.proposalBioimpresiónspa
dc.subject.proposalDegradaciónspa
dc.subject.proposalPropiedades mecánicasspa
dc.subject.proposalBiofísicaspa
dc.subject.proposalBiodegradabilidadspa
dc.subject.proposalPolímerosspa
dc.titleEfecto del compuesto ácido poliláctico/policaprolactona y la geometría en stents biodegradables impresos 3D para el tratamiento de aterosclerosisspa
dc.title.translatedEffect of Polylactic Acid/Polycaprolactone composite and geometry on 3D printed biodegradable stents for atherosclerosis treatmentspa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTrabajo de Gradospa
dc.type.redcolhttp://purl.org/redcol/resource_type/TP

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