Eosinofilia y neutropenia en pacientes con rinofaringitis aguda de un centro de salud de Perú: un estudio analítico

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dc.contributor.authorGuevara Tirad, Alberto
dc.contributor.orcidGuevara Tirad, Alberto [0000-0001-7536-7884]spa
dc.date.accessioned2024-12-16T19:31:46Z
dc.date.available2024-12-16T19:31:46Z
dc.date.issued2024-07-31
dc.description.abstractLos eosinófilos modulan la inmunidad innata y adaptativa. Su elevación puede estar asociada a cambios en las concentraciones de neutrófilos durante la infección aguda de vías respiratorias superiores. El objetivo fue analizar la asociación entre eosinofilia y neutropenia en pacientes con rinofaringitis aguda. Metodología. Estudio transversal y analítico, basado en datos de historias clínicas de 526 pacientes de un policlínico del distrito de Villa el Salvador, Perú. Fueron seleccionados pacientes diagnosticados por rinofaringitis aguda que se realizaron un hemograma completo. Se excluyó a pacientes con enfermedades respiratorias y hematológicas crónicas. Se realizó estadística bivariada con frecuencias y porcentajes, así como la prueba de Odds Ratio crudo y ajustado por regresión logística binaria. Resultados. Los menores de edad con neutropenia tuvieron eosinofilia 5.52 veces más a menudo que aquellos sin neutropenia (OR=5.52; IC:95%=2.28-13.35; p=0.005). En adultos fue 2.01 (OR=2.01; IC:95%=1.07-3.77; p=0.027). Discusión. Los hallazgos podrían atribuirse a la actividad antiviral de los eosinófilos por mecanismos mediados por ribonucleasas y neurotoxinas, los cuales requieren de la activación mediada por neutrófilos en presencia de cuadros infecciosos virales y bacterianos. A su vez, la mayor fuerza de asociación en menores de edad podría deberse a que su sistema inmunológico está en menor madurez que los adultos, quienes además se medican con mayor frecuencia. Conclusiones. La neutropenia y la eosinofilia tuvieron una mayor fuerza de asociación en pacientes con rinofaringitis aguda, principalmente en menores de edad.spa
dc.description.abstractenglishEosinophils modulate innate and adaptive immunity. Their elevation may be associated with changes in neutrophil concentrations during acute upper respiratory tract infection. The objective was to analyze the association between eosinophilia and neutropenia in patients with acute rhinopharyngitis. Methodology. Cross-sectional and analytical study, based on data from medical records of 526 patients from a polyclinic in the district of Villa el Salvador, Peru. Patients diagnosed with acute rhinopharyngitis who underwent a complete blood count were selected. Patients with chronic respiratory and hematologic diseases were excluded. Bivariate statistics with frequencies and percentages were performed, as well as the crude Odds Ratio test and adjusted by binary logistic regression. Results. Minors with neutropenia had eosinophilia 5.52 times more often than those without neutropenia (OR=5.52; CI:95%=2.28-13.35; p=0.005). In adults it was 2.01 (OR=2.01; CI:95%=1.07-3.77; p=0.027). Discussion. The findings could be attributed to the antiviral activity of eosinophils by mechanisms mediated by ribonucleases and neurotoxins, which require neutrophilmediated activation in the presence of viral and bacterial infectious conditions. In turn, the greater strength of the association in minors could be due to the fact that their immune system is less mature than that of adults, who also take medication more frequently. Conclusions. Neutropenia and eosinophilia were more strongly associated in patients with acute rhinopharyngitis, mainly in minors.eng
dc.description.abstractotherOs eosinófilos modulam a imunidade inata e adaptativa. Sua elevação pode estar associada a alterações nas concentrações de neutrófilos durante infecção aguda do trato respiratório superior. O objetivo foi analisar a associação entre eosinofilia e neutropenia em pacientes com rinofaringite aguda. Metodologia. Estudo transversal e analítico, baseado em dados de prontuários de 526 pacientes de uma policlínica do distrito de Villa el Salvador, Peru. Foram selecionados pacientes com diagnóstico de rinofaringite aguda e submetidos a hemograma completo. Foram excluídos pacientes com doenças respiratórias e hematológicas crônicas. Foram realizadas estatísticas bivariadas com frequências e porcentagens, bem como o teste Odds Ratio bruto e ajustado por regressão logística binária. Resultados. Menores com neutropenia apresentaram eosinofilia 5.52 vezes mais frequentemente que aqueles sem neutropenia (OR=5.52; IC 95%=2.28-13.35; p=0.005). Nos adultos foi de 2.01 (OR=2.01; IC: 95%=1.07-3.77; p=0.027). Discussão. Os achados podem ser atribuídos à atividade antiviral dos eosinófilos através de mecanismos mediados por ribonucleases e neurotoxinas, que requerem ativação mediada por neutrófilos na presença de condições infecciosas virais e bacterianas. Por sua vez, a maior força de associação nos menores pode ser devida ao fato do seu sistema imunitário ser menos maduro do que o dos adultos, que também tomam medicamentos com mais frequência. Conclusões. Neutropenia e eosinofilia tiveram maior força de associação nos pacientes com rinofaringite aguda, principalmente nos menores.por
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.29375/01237047.4604
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga UNABspa
dc.identifier.issni-ISSN 0123-7047spa
dc.identifier.issne-ISSN 2382-4603spa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/27773
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.relationhttps://revistas.unab.edu.co/index.php/medunab/article/view/4604/4033spa
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dc.relation.urihttps://revistas.unab.edu.co/index.php/medunab/issue/view/299spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.sourceVol. 27 Núm. 1 (2024): abril - julio 2024: Salud Pública, Salud Materna, Exposición a la Violencia; 17-24spa
dc.subjectNeutrófilosspa
dc.subjectEosinófilosspa
dc.subjectResfriado Comúnspa
dc.subjectAdultospa
dc.subjectAdolescentespa
dc.subjectNiñospa
dc.subject.keywordsMedical scienceseng
dc.subject.keywordsLife scienceseng
dc.subject.keywordsNeutrophilseng
dc.subject.keywordsEosinophilseng
dc.subject.keywordsCommon Coldeng
dc.subject.keywordsAdulteng
dc.subject.keywordsAdolescenteng
dc.subject.keywordsChildeng
dc.subject.keywordsNeutrófilospor
dc.subject.keywordsEosinófilospor
dc.subject.keywordsResfriado Comumpor
dc.subject.keywordsAdultopor
dc.subject.keywordsAdolescentepor
dc.subject.keywordsCriançapor
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsLife scienceseng
dc.subject.keywordsHealth scienceseng
dc.subject.keywordsCiências médicaseng
dc.subject.keywordsCiências da vidapor
dc.subject.keywordsCiências da saúdepor
dc.subject.lembCiencias médicasspa
dc.subject.lembCiencias de la vidaspa
dc.subject.lembCiencias de la saludspa
dc.titleEosinofilia y neutropenia en pacientes con rinofaringitis aguda de un centro de salud de Perú: un estudio analíticospa
dc.title.translatedEosinophilia and neutropenia in patients with acute rhinopharyngitis in a health center in Peru: an analytical studyeng
dc.title.translatedEosinofilia e neutropenia em pacientes com rinofaringite aguda de um centro de saúde no Peru: um estudo analíticopor
dc.typeArticleeng
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.type.localArtículospa
dc.type.redcolhttp://purl.org/redcol/resource_type/ART

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