Polimorfismo Glu298Asp de la NOSE en población negra colombiana con preeclampsia

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dc.contributor.authorSerrano Díaz, Norma Cecilia
dc.contributor.authorPáez Leal, María Carolina
dc.contributor.authorMesa Cornejo, Viviana Matilde
dc.contributor.cvlacPáez Leal, María Carolina [0000066656]spa
dc.contributor.cvlacSerrano Díaz, Norma Cecilia [0000066613]spa
dc.contributor.googlescholarPáez Leal, María Carolina [BAPR3-cAAAAJ]spa
dc.contributor.googlescholarSerrano Díaz, Norma Cecilia [iDn0AAAAAJ&hl=es&oi=ao]spa
dc.contributor.orcidPáez Leal, María Carolina [0000-0002-0310-0125]spa
dc.contributor.orcidSerrano Díaz, Norma Cecilia [0000-0003-3532-2002]spa
dc.contributor.researchgatePáez Leal, María Carolina [Maria_Paez-Leal]spa
dc.contributor.researchgroupGrupo de Estudio Genético de Enfermedades Complejasspa
dc.contributor.researchgroupGrupo de Investigaciones Clínicasspa
dc.contributor.scopusPáez Leal, María Carolina [12243485600]spa
dc.contributor.scopusSerrano Díaz, Norma Cecilia [7003706613]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialBucaramanga (Santander, Colombia)spa
dc.coverage.temporal2002spa
dc.date.accessioned2023-11-20T16:14:14Z
dc.date.available2023-11-20T16:14:14Z
dc.date.issued2002
dc.description.abstractLa Preeclampsia (PE), es una enfermedad frecuente que ocurre entre el 5a 7% de todos los embarazos en el mundo, sin embargo, las marcada variaciones geográficas, sociales, económicas y étnicas determinan poblaciones que alcanzan incidencias hasta tres veces mayores. En Colombia es la principal causa de morbimortalidad materna, con más del 42% de fallecimientos atribuibles a este desorden, además se asocia con un incremento de cinco veces en la mortalidad perinatal. A pesar del gran impacto social y económico, la etiología y fisiopatología de la PE no están totalmente determinadas. Se considera una enfermedad compleja con una susceptibilidad genética de base y múltiples factores medioambientales y concomitantes a la gestación que determinan la aparición y el curso de la enfermedad. Nuestro grupo ha venido trabajando con pacientes Preeclámpticas de cuatro regiones colombianas, estableciendo la frecuencia del polimorfismo Glu298Asp de la Óxido Nítrico Sintasa Endotelial (NOSe), el cual se ha asociado con varias enfermedades que tienen en común a la PE, disfunción endotelial. Hemos encontrado una frecuencia mayor del polimorfismo en las pacientes con PE comparado con las gestantes normotensas; pero la muestra estudiada corresponde a mujeres en su mayoría mestizas con predominio blanco o indígena. Dado que los polimorfismos genéticos pueden variar su frecuencia dependiendo de la etnia estudiada, y que es bien conocido que en la etnia negra la PE en más frecuente y de mayor severidad, pretendemos analizar la frecuencia del polimorfismo Glu298Asp en población negra y comparar los resultados con los obtenidos en nuestro estudio preliminar (PREGENO), tratando de establecer si existen diferencias significativas que pudieran explicar la mayor frecuencia y severidad de la Preeclampsia en la población negra a estudio.spa
dc.description.abstractenglishPreeclampsia (PE) is a common disease that occurs between 5 to 7% of all pregnancies in the world; however, marked geographic, social, economic and ethnic variations determine populations that reach incidences up to three times higher. In Colombia it is the main cause of maternal morbidity and mortality, with more than 42% of deaths attributable to this disorder, and it is also associated with a five-fold increase in perinatal mortality. Despite the great social and economic impact, the etiology and pathophysiology of PE are not fully determined. It is considered a complex disease with an underlying genetic susceptibility and multiple environmental and pregnancy-related factors that determine the onset and course of the disease. Our group has been working with Preeclamptic patients from four Colombian regions, establishing the frequency of the Glu298Asp polymorphism of Endothelial Nitric Oxide Synthase (eNOS), which has been associated with several diseases that have endothelial dysfunction in common with PE. We have found a higher frequency of the polymorphism in patients with PE compared to normotensive pregnant women; but the sample studied corresponds to mostly mestizo women with white or indigenous predominance. Given that genetic polymorphisms can vary in frequency depending on the ethnic group studied, and that it is well known that in black ethnic groups PE is more frequent and of greater severity, we intend to analyze the frequency of the Glu298Asp polymorphism in the black population and compare the results with those obtained in our preliminary study (PREGENO), trying to establish if there are significant differences that could explain the greater frequency and severity of Preeclampsia in the black population under study.spa
dc.description.learningmodalityModalidad Presencialspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/22851
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsMaternal morbidity and mortalityspa
dc.subject.keywordsGenetic diseasespa
dc.subject.keywordsRacial pigmentationspa
dc.subject.keywordsPolymorphismspa
dc.subject.keywordsHypertension in pregnancyspa
dc.subject.keywordsGeneticsspa
dc.subject.lembPolimorfismospa
dc.subject.lembPreeclampsiaspa
dc.subject.lembHipertensión en el embarazospa
dc.subject.lembGenéticaspa
dc.subject.proposalMorbimortalidad maternaspa
dc.subject.proposalEnfermedad genéticaspa
dc.subject.proposalPigmentación racialspa
dc.titlePolimorfismo Glu298Asp de la NOSE en población negra colombiana con preeclampsiaspa
dc.title.translatedGlu298Asp polymorphism of NOSe in a black Colombian population with preeclampsiaspa
dc.typeResearch reporteng
dc.type.coarhttp://purl.org/coar/resource_type/c_18ws
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/workingPaperspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localInforme de investigaciónspa
dc.type.redcolhttp://purl.org/redcol/resource_type/IFIspa

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