Efecto del bloqueo serrato anterior en el control del dolor postoperatorio en cirugía de cáncer de mama

dc.contributor.advisorTrujillo, Nestor
dc.contributor.advisorGómez Garces, Sonia Luz
dc.contributor.apolounabGómez Garces, Sonia Luz [sonia-luz-gomez-garces]spa
dc.contributor.authorAlvernia Pinto, María Juliana
dc.contributor.cvlacGómez Garces, Sonia Luz [0001659600]spa
dc.contributor.cvlacAlvernia Pinto, María Juliana [0001693706]spa
dc.contributor.googlescholarGómez Garces, Sonia Luz [es&oi=ao]spa
dc.contributor.orcidGómez Garces, Sonia Luz [0000-0003-1865-2923]spa
dc.contributor.orcidAlvernia Pinto, María Juliana [0009-0009-5436-0726]spa
dc.coverage.campusUNAB Campus Bucaramangaspa
dc.coverage.spatialFloridablanca (Santander, Colombia)spa
dc.coverage.temporalMayo Julio 2024spa
dc.date.accessioned2025-06-05T13:48:37Z
dc.date.available2025-06-05T13:48:37Z
dc.date.issued2025-05-27
dc.degree.nameEspecialista en Anestesiologíaspa
dc.description.abstractEl cáncer de mama (CM) continúa siendo la forma más común de neoplasia maligna en mujeres. Su creciente incidencia ha llevado a que la cirugía por cáncer de mama (CCM) sea cada vez más frecuente, la cual se asocia a dolor postoperatorio moderado a severo que retrasa la recuperación. Es por esto que surge el estudio analítico de cohorte prospectiva, que evaluó el efecto del bloqueo serrato anterior (BPSA) en el control del dolor postoperatorio en CCM. Se realizo en pacientes mayores de 18 años sometidas a CCM a quienes según concepto del anestesiólogo se les realizó BPSA guiados por ultrasonografía combinado con anestesia general y analgesia convencional. La variable principal fue el cambio en la valoración del dolor en la escala numérica del dolor a las 0,12,24 y 72 horas postoperatorias. Como desenlace secundario evaluar los efectos secundarios de las técnicas descritas. 130 pacientes fueron evaluadas, 65 pacientes sin bloqueo y 65 pacientes en el grupo de BPSA. La media más alta respecto al dolor se registró a las 0 horas postoperatorias, siendo de 6.69 (DE = 2.02, IC 95%: 6.19 – 7.21) en pacientes sin BPSA frente a 2.76 (DE = 1.60, IC 95%: 3.27 – 3.17) en pacientes con BPSA (p < 0.01). La media de dolor más baja se presentó a las 72 horas, con una media de 1.60 (DE = 1.45, IC 95%: 1.24 – 1.97) en pacientes sin BPSA frente a 0.63 (DE = 1.15, IC 95%: 0.34 – 0.92) en pacientes con BPSA (p < 0.01). La incidencia de de nausea y vomito POP fue de 15,38% en el grupo con BPSA versus el 46,03% en el grupo sin BPSA. Con una prevalencia de 0% de complicaciones.spa
dc.description.abstractenglishBreast cancer (BC) remains the most common form of malignancy in women. Its rising incidence has led to an increasing frequency of breast cancer surgery (BCS), which is associated with moderate to severe postoperative pain that delays recovery. This prospective cohort study was conducted to evaluate the effect of serratus anterior block (SABP) on postoperative pain control in BSC. The study was conducted in patients over 18 years of age undergoing BSC. According to the anesthesiologist's opinion, these patients underwent ultrasound-guided SABP combined with general anesthesia and conventional analgesia. The primary endpoint was the change in pain scores on the numerical pain scale at 0, 12, 24, and 72 hours postoperatively. The secondary outcome was to evaluate the side effects of the described techniques. One hundred thirty patients were evaluated: 65 without the block and 65 in the SABP group. The highest mean pain score was recorded at 0 hours postoperatively, being 6.69 (SD = 2.02, 95% CI: 6.19–7.21) in patients without BPSA versus 2.76 (SD = 1.60, 95% CI: 3.27–3.17) in patients with BPSA (p < 0.01). The lowest mean pain score was recorded at 72 hours, with a mean of 1.60 (SD = 1.45, 95% CI: 1.24–1.97) in patients without BPSA versus 0.63 (SD = 1.15, 95% CI: 0.34–0.92) in patients with BPSA (p < 0.01). The incidence of nausea and vomiting (POP) was 15.38% in the BPSA group versus 46.03% in the non-BPSA group, with a 0% prevalence of complications.spa
dc.description.degreelevelEspecializaciónspa
dc.description.learningmodalityModalidad Presencialspa
dc.description.tableofcontentsResumen 3 Introducción 5 1. Planteamiento del problema 6 2. Pregunta de Investigación 6 3. Hipótesis de trabajo 7 4. Justificación 7 5. Marco teórico 9 6. Estado del Arte 20 7. Objetivos 25 7.1. Objetivo General 25 7.2. Objetivos específicos 25 8. Metodología 25 8.1. Tipo de estudio 25 8.2. Población 25 8.3. Criterios de inclusión 26 8.4. Criterios de exclusión 26 8.5. Cálculo de tamaño de muestra 26 8.6. Muestreo 27 8.7. Recolección de la información 27 8.8. Variables 29 8.9. Plan de análisis de datos 32 8.10. Consideraciones éticas. 33 9. Resultados 35 10. Análisis y discusión 45 11. Limitaciones 50 12. Conclusiones 51 13. Referencias bibliográficas 51 16. Anexos 57 16.1. Impacto y resultados esperados 57 16.2. Alcances del trabajo de grado 58 16.3. Instrumento de recolección de la información 58 16.4. Documento consentimiento informado 61 16.5. Cronograma de actividades 66 16.6. Presupuesto 66spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameinstname:Universidad Autónoma de Bucaramanga - UNABspa
dc.identifier.reponamereponame:Repositorio Institucional UNABspa
dc.identifier.repourlrepourl:https://repository.unab.edu.cospa
dc.identifier.urihttp://hdl.handle.net/20.500.12749/29406
dc.language.isospaspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.publisher.grantorUniversidad Autónoma de Bucaramanga UNABspa
dc.publisher.programEspecialización en Anestesiologíaspa
dc.publisher.programidEANE-1049
dc.relation.referencesWorld health organization. Data visualization tools for exploring the global cancer burden in 2022. International agency for research on cancer. [Internet]. 2022. Disponible en: https://gco.iarc.fr/today/enspa
dc.relation.referencesFecho K, Miller NR, Merritt SA, Klauber-Demore N, Hultman CS, Blau WS. Acute and persistent postoperative pain after breast surgery. Pain Med. 2009 May-Jun;10(4):708-15.spa
dc.relation.referencesChai B, Yu H, Qian Y, Chen X, Zhu Z, Du J, Kang X, Zhu S. Comparison of Postoperative Pain in 70 Women with Breast Cancer Following General Anesthesia for Mastectomy with and without Serratus Anterior Plane Nerve Block. Med Sci Monit. 2022 Feb 7;28:e934064.spa
dc.relation.referencesArora S, Ovung R, Bharti N, Yaddanapudi S, Singh G. Efficacy of serratus anterior plane block versus thoracic paravertebral block for postoperative analgesia after breast cancer surgery - a randomized trial. Braz J Anesthesiol. 2022 Sep-Oct;72(5):587-592.spa
dc.relation.referencesChen JQ, Yang XL, Gu H, Chai XQ, Wang D. The Role of Serratus Anterior Plane Block During in Video-Assisted Thoracoscopic Surgery. Pain Ther. 2021 Dec;10(2):1051-1066.spa
dc.relation.referencesCui Q, Jiang D, Zhang Y, Chen C. The tumor-nerve circuit in breast cancer. Cancer Metastasis Rev. 2023 Jun;42(2):543-574. Szamborski M, Janc J, Rosińczuk J, Janc JJ, Leśnik P, Łysenko L. Use of Ultrasound-Guided Interfascial Plane Blocks in Anterior and Lateral Thoracic Wall Region as Safe Method for Patient Anesthesia and Analgesia: Review of Techniques and Approaches during COVID-19 Pandemic. Int J Environ Res Public Health. 2022 Jul 17;19(14):8696.spa
dc.relation.referencesSmeele HP, Bijkerk E, van Kuijk SMJ, Lataster A, van der Hulst RRWJ, Tuinder SMH. Innervation of the Female Breast and Nipple: A Systematic Review and Meta-Analysis of Anatomical Dissection Studies. Plast Reconstr Surg. 2022 Aug 1;150(2):243-255.spa
dc.relation.referencesRicbourg B. Applied anatomy of the breast: blood supply and innervation. Ann Chir Plast Esthet. 1992 Dec;37(6):603-20.spa
dc.relation.referencesJaspars JJ, Posma AN, van Immerseel AA, Gittenberger-de Groot AC. The cutaneous innervation of the female breast and nipple-areola complex: Implications for surgery. Br J Plast Surg. 1997;50:249-259.spa
dc.relation.referencesJesinger RA. Breast anatomy for the interventionalist. Tech Vasc Interv Radiol. 2014 Mar;17(1):3-9.spa
dc.relation.referencesVasquez W, Daza G, Escobar W. Valoración de la arteria toracodorsal con ultrasonido Doppler en voluntarios sanos en un hospital de tercer nivel. Rev Colomb Radiol. 2011; 22(2): 3158-63. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249.spa
dc.relation.referencesKashyap D, Pal D, Sharma R, Garg VK, Goel N, Koundal D, Zaguia A, Koundal S, Belay A. Global Increase in Breast Cancer Incidence: Risk Factors and Preventive Measures. Biomed Res Int. 2022 Apr 18;2022:9605439.spa
dc.relation.referencesTrayes KP, Cokenakes SEH. Breast Cancer Treatment. Am Fam Physician. 2021 Aug 1;104(2):171-178. Nanda A, Hu J, Hodgkinson S, Ali S, Rainsbury R, Roy PG. Oncoplastic breast-conserving surgery for women with primary breast cancer. Cochrane Database Syst Rev. 2021 Oct 29;10(10):CD013658.spa
dc.relation.referencesAl-Hilli Z, Wilkerson A. Breast Surgery: Management of Postoperative Complications Following Operations for Breast Cancer. Surg Clin North Am. 2021 Oct;101(5):845-863.spa
dc.relation.referencesChatterjee A, Gass J, Patel K, Holmes D, Kopkash K, Peiris L, Peled A, Ryan J, El-Tamer M, Reiland J. A Consensus Definition and Classification System of Oncoplastic Surgery Developed by the American Society of Breast Surgeons. Ann Surg Oncol. 2019 Oct;26(11):3436-3444.spa
dc.relation.referencesAndersen KG, Kehlet H. Persistent pain after breast cancer treatment: a critical review of risk factors and strategies for prevention. J Pain. 2011 Jul;12(7):725-46.spa
dc.relation.referencesWang L, Guyatt GH, Kennedy SA, et al. Predictors of persistent pain after breast cancer surgery: A systematic review and meta-analysis of observational studies. CMAJ. 2016;188(14):E352–61.spa
dc.relation.referencesLönnqvist PA, MacKenzie J, Soni AK, Conacher ID. Paravertebral blockade. Failure rate and complications. Anaesthesia. 1995 Sep;50(9):813-5.spa
dc.relation.referencesMayes J, Davison E, Panahi P, Patten D, Eljelani F, Womack J, Varma M. An anatomical evaluation of the serratus anterior plane block. Anaesthesia. 2016 Sep;71(9):1064-9.spa
dc.relation.referencesBlanco R, Parras T, McDonnell JG, Prats-Galino A. Serratus plane block: a novel ultrasound-guided thoracic wall nerve block. Anaesthesia. 2013 Nov;68(11):1107-13.spa
dc.relation.referencesBaytar Ç, Aktaş B, Aydin BG, Pişkin Ö, Çakmak GK, Ayoğlu H. The effects of ultrasound-guided serratus anterior plane block on intraoperative opioid consumption and hemodynamic stability during breast surgery: A randomized controlled study. Medicine (Baltimore). 2022 Sep 2;101(35):e30290.spa
dc.relation.referencesMeng J, Zhao HY, Zhuo XJ, Shen QH. Postoperative Analgesic Effects of Serratus Anterior Plane Block for Thoracic and Breast Surgery: A Meta-analysis of Randomized Controlled Trials. Pain Physician. 2023 Mar;26(2):E51-E62.spa
dc.relation.referencesShi K, Chen Y, Liu L, Zheng L, Huang L, Wang Q, Yang J. Comparison of the effect of different volumes ropivacaine on deep serratus anterior plane block in patients undergoing breast surgery: a prospective randomized double-blinded trial. Ann Palliat Med. 2021 Jun;10(6):6104-6111.spa
dc.relation.referencesAbdallah FW, Cil T, MacLean D, Madjdpour C, Escallon J, Semple J, Brull R. Too Deep or Not Too Deep?: A Propensity-Matched Comparison of the Analgesic Effects of a Superficial Versus Deep Serratus Fascial Plane Block for Ambulatory Breast Cancer Surgery. Reg Anesth Pain Med. 2018 Jul;43(5):480-487.spa
dc.relation.referencesEdwards JT, Langridge XT, Cheng GS, et al.. Superficial vs. deep serratus anterior plane block for analgesia in patients undergoing mastectomy: a randomized prospective trial. J Clin Anesth. 2021;75:110470.spa
dc.relation.referencesBakeer AH, Kamel KM, Abdelgalil AS, Ghoneim AA, Abouel Soud AH, Hassan ME. Modified pectoral nerve block versus serratus block for analgesia following modified radical mastectomy: a randomized controlled trial. J Pain Res. 2020;13:1769–75.spa
dc.relation.referencesRashwan DAEK, Mohammed AR, Kasem Rashwan SA, Abd El Basset AS, Nafady HA. Efficacy of Serratus Anterior Plane Block Using Bupivacaine/ Magnesium Sulfate Versus Bupivacaine/ Nalbuphine for Mastectomy: A Randomized, Double-Blinded Comparative Study. Anesth Pain Med. 2020 Jun 22;10(3):e103141.spa
dc.relation.referencesRahimzadeh P, Imani F, Faiz SHR, Boroujeni BV. Impact of the Ultrasound-Guided Serratus Anterior Plane Block on Post-Mastectomy Pain: A Randomised Clinical Study. Turk J Anaesthesiol Reanim. 2018 Sep;46(5):388-392.spa
dc.relation.referencesOhgoshi Y, Yokozuka M, Terajima K. [Serratus-Intercostal Plane Block for Brest Surgery]. Masui. 2015 Jun;64(6):610-4.spa
dc.relation.referencesHards M, Harada A, Neville I, Harwell S, Babar M, Ravalia A, Davies G. The effect of serratus plane block performed under direct vision on postoperative pain in breast surgery. J Clin Anesth. 2016 Nov;34:427-31.spa
dc.relation.referencesHu NQ, He QQ, Qian L, Zhu JH. Efficacy of Ultrasound-Guided Serratus Anterior Plane Block for Postoperative Analgesia in Patients Undergoing Breast Surgery: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Pain Res Manag. 2021 Oct 25;2021:7849623.spa
dc.relation.referencesBhan S, Mishra S, Gupta N, Garg R, Vig S, Thulkar S, Kumar R, Bhatnagar S. A Prospective Randomised Study to Assess the Analgesic Efficacy of Serratus Anterior Plane (SAP) Block for Modified Radical Mastectomy Under General Anaesthesia. Turk J Anaesthesiol Reanim. 2021 Apr;49(2):124-129.spa
dc.relation.referencesAstudillo M, Rigo D. Analgesia postoperatoria con bloqueo del plano serrato bajo ecografía en cirugía de mama. Rev. chil. anest. Vol. 43 Suplemento 1: 214-225.spa
dc.relation.referencesYoon HS, Yu BW, Kim YM, Lee JH, Koh WU, Yang HS. Serratus anterior plane block combined with monitored anesthesia care for surgery of lateral side of breast -a case report. Korean J Anesthesiol. 2019 Oct;72(5):500-503.spa
dc.relation.referencesSantonastaso DP, DE Chiara A, Bagaphou CT, Cittadini A, Marsigli F, Russo E, Agnoletti V. Erector spinae plane block associated to serratus anterior plane block for awake radical mastectomy in a patient with extreme obesity. Minerva Anestesiol. 2021 Jun;87(6):734-736. Minsalud. Resolución N° 8430 de 1993. Por la cual se establecen las normas científicas, técnicas y administrativas para la investigación en salud. [Internet]. 1993. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/RESOLUCION-8430-DE-1993.PDF.spa
dc.relation.referencesGhamry M, Amer A. Role of erector spinae plane block versus paravertebral block in pain control after modified radical mastectomy. A prospective randomised trial. Indian Journal of Anaesthesia. 2019;63(12):1008–1014.spa
dc.relation.referencesNiesen A. D, Jacob A. K., Law L. A., Sviggum H. P, Johnson R. L. Complication rate of ultrasound-guided paravertebral block for breast surgery. Regional Anesthesia and Pain Medicine . 2020;45(10):813–817.spa
dc.relation.referencesAstudillo Aliste M, Rigo-Righi Irrazabal D. Analgesia postoperatoria con bloqueo del plano serrato bajo ecografía en cirugía de mama. Rev. Chilena de Anestesia. 2014;43(1). Vilchis-Rentería J, González-Guzmán M. Bloqueo del plano serrato y del plano transverso torácico guiados por ultrasonido. Rev. Mexicana de Anestesiología. 2016; Vol. 39(1): S212-S213.spa
dc.relation.referencesCDC. Breast Cancer Risk Factors. [Internet]. 2024. Disponible en: https://www.cdc.gov/breast-cancer/risk-factors/index.html. L. Kwan M, Risk of Cardiometabolic Risk Factors in Women With and Without a History of Breast Cancer: The Pathways Heart Study. JCO 40, 1635-1646(2022).spa
dc.relation.referencesTang W, Luo G, Lu Y, Chen C, Liu H, Li Y. Application of a new serratus anterior plane block in modified radical mastectomy under ultrasound guidance: A prospective, randomized controlled trial. J Clin Anesth. 2021;74:110377.spa
dc.relation.referencesLiang W. Efficacy and safety of ultrasound-guided serratus anterior plane block for postoperative analgesia in thoracic surgery and breast surgery: A systematic review and meta-analysis of randomized controlled studies. Front. Anesthesiol, 2022 (1).spa
dc.relation.referencesAbdallah FW, Patel V, Madjdpour C, Cil T, Brull R. Quality of recovery scores in deep serratus anterior plane block vs. sham block in ambulatory breast cancer surgery: a randomised controlled trial. Anaesthesia. 2021 Sep;76(9):1190-1197.spa
dc.relation.uriapolohttps://apolo.unab.edu.co/en/persons/sonia-luz-gomez-garcesspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subject.keywordsAnesthesiologyspa
dc.subject.keywordsMedical sciencesspa
dc.subject.keywordsHealth sciencesspa
dc.subject.keywordsMedicinespa
dc.subject.keywordsBreast cancer surgeryspa
dc.subject.keywordsSerratus anterior plane blockspa
dc.subject.keywordsControl of acute postoperative painspa
dc.subject.keywordsSurgical therapyspa
dc.subject.keywordsSurgery, Operativespa
dc.subject.keywordsBreast (Cancer)spa
dc.subject.keywordsConduction anesthesiaspa
dc.subject.lembAnestesiologíaspa
dc.subject.lembCiencias médicasspa
dc.subject.lembMedicinaspa
dc.subject.lembanestesia regionalspa
dc.subject.lembTerapéutica quirúrgicaspa
dc.subject.lembCirugía operatoriaspa
dc.subject.lembMamas (Cáncer)spa
dc.subject.lembAnestesia de conducciónspa
dc.subject.proposalCiencias de la saludspa
dc.subject.proposalCirugía de cáncer de mamaspa
dc.subject.proposalBloqueo del plano serrato anteriorspa
dc.subject.proposalDolor agudo postoperatoriospa
dc.titleEfecto del bloqueo serrato anterior en el control del dolor postoperatorio en cirugía de cáncer de mamaspa
dc.title.translatedEffect of serratus anterior block on postoperative pain control in breast cancer surgeryspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersion
dc.type.localTesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TM

Archivos

Bloque original

Mostrando 1 - 2 de 2
Cargando...
Miniatura
Nombre:
Tesis MJAP.docx.pdf
Tamaño:
5.11 MB
Formato:
Adobe Portable Document Format
Descripción:
Tesis
Cargando...
Miniatura
Nombre:
Licencia.pdf
Tamaño:
274.39 KB
Formato:
Adobe Portable Document Format
Descripción:
Licencia

Bloque de licencias

Mostrando 1 - 1 de 1
Cargando...
Miniatura
Nombre:
license.txt
Tamaño:
829 B
Formato:
Item-specific license agreed upon to submission
Descripción: